Treatment of a variety of cutaneous fungal infections, including tinea pedis (athlete’s foot), tinea cruris (jock itch), tinea corporis (ringworm), and tinea versicolor.
Action⬆⬇
Affects the synthesis of the fungal cell wall.
Therapeutic effects:
Decrease in symptoms of fungal infection.
Pharmacokinetics⬆⬇
Absorption: Absorption through intact skin is minimal.
Distribution: Distribution after topical administration is primarily local.
Metabolism/Excretion: Hepatic via hydroxylation.
Half-Life: 35 hr.
Time/Action Profile⬆⬇
ROUTE
ONSET
PEAK
DURATION
Top
unknown
up to 4 wk
unknown
Contraind./Precautions⬆⬇
Contraindicated in:
Hypersensitivity to active ingredients, additives, preservatives, or bases;
Some products contain alcohol or bisulfites and should be avoided in patients with known intolerance.
Use Cautiously in:
Nail and scalp infections (may require additional systemic therapy);
OB: Safety not established in pregnancy;
Lactation: Safety not established in breastfeeding;
Pedi: Children 12 yr (safety and effectiveness not established).
Adv. Reactions/Side Effects⬆⬇
Local: burning, itching, local hypersensitivity reactions, redness, stinging
Interactions⬆⬇
Drug-drug:
None significant.
Route/Dosage⬆⬇
(Adults and Children ≥12 yr): Apply once daily for 2 wk for patients with tinea corporis, tinea cruris, or tinea versicolor. Apply once daily for 4 wk or twice daily for 7 days for patients with tinea pedis.
Availability⬆⬇
(Generic available)
Cream: 1% Rx, OTC
Assessment⬆⬇
Inspect involved areas of skin and mucous membranes before and frequently during therapy. Increased skin irritation may indicate need to discontinue medication.
Implementation⬆⬇
Consult health care professional for proper cleansing technique before applying medication.
Apply small amount to cover affected area completely. Avoid the use of occlusive wrappings or dressings unless directed by health care professional.
Patient/Family Teaching⬆⬇
Instruct patient to apply medication as directed for full course of therapy, even if feeling better. Emphasize the importance of avoiding the eyes or vaginal area.
Caution patient that some products may stain fabric, skin, or hair. Check label information. Fabrics stained from cream can usually be cleaned by handwashing with soap and warm water.
Patients with athlete’s foot should be taught to wear well-fitting, ventilated shoes, to wash affected areas thoroughly, and to change shoes and socks at least once a day.
Advise patient to report increased skin irritation or lack of response to therapy to health care professional.
Early relief of symptoms may be seen in 2–3 days. For tinea cruris, tinea corporis, and tinea versicolor, 2 wk are needed, and for tinea pedis, therapeutic response may take 4 wk. Recurrent fungal infections may be a sign of systemic illness.
Evaluation/Desired Outcomes⬆⬇
Decrease in skin irritation and.
Resolution of infection.
US Brand Names⬆⬇
Lotrimin Ultra
Code⬆
NDC Code
0363- Walgreen Company
0363-2100- Athletes Foot
0363-2100-02- 1 TUBE in 1 CARTON (0363-2100-02) > 30 g in 1 TUBE
0363- Walgreen Company
0363-2101- Jock Itch
0363-2101-08- 1 TUBE in 1 CARTON (0363-2101-08) > 12 g in 1 TUBE
0378- Mylan Pharmaceuticals Inc.
0378-6151- MENTAX
0378-6151-46- 1 TUBE in 1 CARTON (0378-6151-46) > 15 g in 1 TUBE
0378- Mylan Pharmaceuticals Inc.
0378-6151- MENTAX
0378-6151-49- 1 TUBE in 1 CARTON (0378-6151-49) > 30 g in 1 TUBE
11523- Bayer Healthcare LLC.
11523-4338- Lotrimin Ultra Athletes Foot
11523-4338-1- 1 TUBE in 1 CARTON (11523-4338-1) > 12 g in 1 TUBE
11523- Bayer Healthcare LLC.
11523-4338- Lotrimin Ultra Athletes Foot
11523-4338-2- 1 TUBE in 1 CARTON (11523-4338-2) > 15 g in 1 TUBE
11523- Bayer Healthcare LLC.
11523-4338- Lotrimin Ultra Athletes Foot
11523-4338-4- 1 TUBE in 1 CARTON (11523-4338-4) > 30 g in 1 TUBE
11523- Bayer Healthcare LLC.
11523-4339- Lotrimin Ultra Jock Itch
11523-4339-1- 1 TUBE in 1 CARTON (11523-4339-1) > 12 g in 1 TUBE
11523- Bayer Healthcare LLC.
11523-4339- Lotrimin Ultra Jock Itch
11523-4339-2- 1 TUBE in 1 CARTON (11523-4339-2) > 15 g in 1 TUBE
11673- Target Corporation
11673-016- Athletes Foot
11673-016-02- 1 TUBE in 1 CARTON (11673-016-02) > 30 g in 1 TUBE
11822- Rite Aid Corporation
11822-2100- Athletes Foot
11822-2100-2- 1 TUBE in 1 CARTON (11822-2100-2) > 30 g in 1 TUBE
11822- Rite Aid Corporation
11822-2100- Athletes Foot
11822-2100-8- 1 TUBE in 1 CARTON (11822-2100-8) > 12 g in 1 TUBE
36800- TOPCO ASSOCIATES LLC
36800-049- Athletes Foot
36800-049-01- 1 TUBE in 1 CARTON (36800-049-01) > 12 g in 1 TUBE
37808- H E B
37808-013- Athletes Foot Ultra
37808-013-02- 1 TUBE in 1 CARTON (37808-013-02) > 12 g in 1 TUBE
49035- Wal-Mart Stores Inc
49035-178- Butenafine Hydrochloride Jock Itch
49035-178-08- 1 TUBE in 1 CARTON (49035-178-08) > 12 g in 1 TUBE
49035- Wal-Mart Stores Inc
49035-225- Athletes Foot Ultra
49035-225-08- 1 TUBE in 1 CARTON (49035-225-08) > 12 g in 1 TUBE
51672- Taro Pharmaceuticals U.S.A., inc.
51672-2100- Athletes Foot
51672-2100-1- 1 TUBE in 1 CARTON (51672-2100-1) > 15 g in 1 TUBE
51672- Taro Pharmaceuticals U.S.A., inc.
51672-2100- Athletes Foot
51672-2100-2- 1 TUBE in 1 CARTON (51672-2100-2) > 30 g in 1 TUBE
51672- Taro Pharmaceuticals U.S.A., inc.
51672-2100- Athletes Foot
51672-2100-8- 1 TUBE in 1 CARTON (51672-2100-8) > 12 g in 1 TUBE
51672- Taro Pharmaceuticals U.S.A., inc.
51672-2100- Athletes Foot
51672-2100-9- 1 TUBE in 1 CARTON (51672-2100-9) > 24 g in 1 TUBE
51672- Taro Pharmaceuticals U.S.A., inc.
51672-2101- Jock Itch
51672-2101-1- 1 TUBE in 1 CARTON (51672-2101-1) > 15 g in 1 TUBE
51672- Taro Pharmaceuticals U.S.A., inc.
51672-2101- Jock Itch
51672-2101-2- 1 TUBE in 1 CARTON (51672-2101-2) > 30 g in 1 TUBE
51672- Taro Pharmaceuticals U.S.A., inc.
51672-2101- Jock Itch
51672-2101-8- 1 TUBE in 1 CARTON (51672-2101-8) > 12 g in 1 TUBE
51672- Taro Pharmaceuticals U.S.A., inc.
51672-2101- Jock Itch
51672-2101-9- 1 TUBE in 1 CARTON (51672-2101-9) > 24 g in 1 TUBE
69842- CVS Pharmacy
69842-986- Athletes Foot
69842-986-02- 1 TUBE in 1 CARTON (69842-986-02) > 30 g in 1 TUBE
69842- CVS Pharmacy
69842-986- Athletes Foot
69842-986-03- 1 TUBE in 1 CARTON (69842-986-03) > 30 g in 1 TUBE
69842- CVS Pharmacy
69842-986- Athletes Foot
69842-986-08- 1 TUBE in 1 CARTON (69842-986-08) > 12 g in 1 TUBE
69842- CVS Pharmacy
69842-989- Butenafine Hydrochloride 1%
69842-989-08- 1 TUBE in 1 CARTON (69842-989-08) > 12 g in 1 TUBE
