section name header

Pronunciation ⬇

si-proe-HEP-ta-deen

Classifications ⬆ ⬇

Therapeutic Classification: allergy, cold and cough remedies, antihistamines

Indications ⬆ ⬇

BEERS REMS

Unlabeled Use:
  • Stimulation of appetite.

Action ⬆ ⬇

  • Antagonizes the effects of histamine at H1-receptor sites; does not bind to or inactivate histamine.
  • Also blocks the effects of serotonin, which may result in increased appetite.
Therapeutic effects:
  • Decreased symptoms of histamine excess (sneezing, rhinorrhea, nasal and ocular pruritus, ocular tearing and redness).
  • Decreased cold urticaria.

Pharmacokinetics ⬆ ⬇

Absorption: Well absorbed following oral administration.

Distribution: Unknown.

Metabolism/Excretion: Mostly metabolized by the liver.

Half-Life: Unknown.

Time/Action Profile ⬆ ⬇

(antihistaminic effects)

ROUTEONSETPEAKDURATION
PO15–60 min1–2 hr8 hr

Contraind./Precautions ⬆ ⬇

Contraindicated in:

Use Cautiously in:

Adv. Reactions/Side Effects ⬆ ⬇

CV: arrhythmias, hypotension, palpitations

Derm: photosensitivity, rash

EENT: blurred vision

GI: dry mouth, constipation

GU: urinary hesitancy, urinary retention

Metab: weight gain

Neuro: drowsiness, excitation (increased in children)

Interactions ⬆ ⬇

Drug-drug:

Route/Dosage ⬆ ⬇

Availability ⬆ ⬇

(Generic available)

Assessment ⬆ ⬇

Lab Test Considerations:

Implementation ⬆ ⬇

Patient/Family Teaching ⬆ ⬇

Evaluation/Desired Outcomes ⬆ ⬇

US Brand Names ⬆ ⬇

Periactin

Code ⬆

NDC Code