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Pronunciation ⬇

o-lo-PA-ta-deen

Classifications ⬆ ⬇

Therapeutic Classification: allergy, cold and cough remedies

Pharmacologic Classification: antihistamines

Indications ⬆ ⬇

REMS

Action ⬆ ⬇

  • Antagonizes the effects of histamine at histamine1 receptor sites; does not bind to or inactivate histamine.
Therapeutic effects:
  • Decreased symptoms of histamine excess including rhinorrhea, sneezing, and nasal itching.

Pharmacokinetics ⬆ ⬇

Absorption: 57% absorbed from nasal mucosa.

Distribution: Unknown.

Metabolism/Excretion: Minimal metabolism; 70% eliminated in urine mostly as unchanged drug; 17% fecal elimination.

Half-Life: 8–12 hr.

Time/Action Profile ⬆ ⬇

ROUTEONSETPEAKDURATION
Nasalrapidunknown12 hr

Contraind./Precautions ⬆ ⬇

Contraindicated in:

Use Cautiously in:

Adv. Reactions/Side Effects ⬆ ⬇

EENT: epistaxis, nasal perforation, nasal ulceration, pharyngolaryngeal pain, postnasal drip

GI: bitter taste

Neuro: drowsiness, headache

Resp: cough

Interactions ⬆ ⬇

Drug-drug:

Route/Dosage ⬆ ⬇

Availability ⬆ ⬇

(Generic available)

Assessment ⬆ ⬇

Implementation ⬆ ⬇

Patient/Family Teaching ⬆ ⬇

Evaluation/Desired Outcomes ⬆ ⬇

US Brand Names ⬆ ⬇

Patanase

Code ⬆

NDC Code