bepotastine

Therapeutic Classification: ocular agents

Pharmacologic Classification: antihistamines

Indications ⬆ ⬇

REMS

Treatment of itching associated with allergic conjunctivitis.

Action ⬆ ⬇

Acts as a histamine H₁ receptor antagonist; also inhibits the release of histamine from mast cells; does not bind to or inactivate histamine.

Therapeutic effects:

Decreased ocular itching associated with allergic conjunctivitis.

Pharmacokinetics ⬆ ⬇

Absorption: Some systemic absorption follows ophthalmic administration.

Distribution: Unknown.

Metabolism/Excretion: Minimally metabolized by the liver; 75–90% excreted unchanged in urine.

Half-Life: Uknown.

Time/Action Profile ⬆ ⬇

(antihistaminic activity)

ROUTE	ONSET	PEAK	DURATION
ophth	within 15 min	1–2 hr‡	12 hr

‡blood levels.

Contraind./Precautions ⬆ ⬇

Contraindicated in:

Hypersensitivity.

Use Cautiously in:

Contact lens use ;
OB: Use during pregnancy potential maternal benefit justifies the potential risk to fetus;
Lactation: Use cautiously during breastfeeding;
Pedi: Safe and effective use in children <2 yr has not been established.

Adv. Reactions/Side Effects ⬆ ⬇

EENT: nasopharyngitis

GI: taste in mouth following instillation

Neuro: headache

Interactions ⬆ ⬇

Drug-drug:

None noted.

Route/Dosage ⬆ ⬇

(Adults ): One drop in affected eye(s) twice daily.

Availability ⬆ ⬇

Ophthalmic solution: 1.5%

Assessment ⬆ ⬇

Assess signs and symptoms of allergic conjunctivitis (redness, itching, watering) periodically during therapy.

Implementation ⬆ ⬇

Instill 1 drop into affected eyes twice daily. See Ophthalmic Medications for administration guidelines.

Patient/Family Teaching ⬆ ⬇

Instruct patient to instill bepotastine drops as directed. Do not touch dropper to eye or to any surface.
Advise patient to remove contact lens prior to instillation. Do not use bepotastine for treatment of irritation related to contact lens. Do not wear contact lens if eyes are red. Contact lens may be reinserted 10 min following instillation.
Advise female patient to notify health care professional if pregnancy is planned or suspected or if breastfeeding.

Evaluation/Desired Outcomes ⬆ ⬇

Decrease in ocular itching due to allergic conjunctivitis.

US Brand Names ⬆ ⬇

Code ⬆

NDC Code

42672- UBE Corporation
- 42672-0100-
  - 42672-0100-1- 2 BAG in 1 DRUM (42672-0100-1) / 15 kg in 1 BAG

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Pronunciation ⬇

Classifications ⬆ ⬇