meth-ill-FEN-i-date
REMS
Absorption: Slow and incomplete after oral administration; absorption of sustained or extended-release tablet (ER) is delayed and provides continuous release; well absorbed from skin. Aptensio XR, Concerta, Relexxii, Ritalin LA: Provides initial rapid release followed by a second continuous release (biphasic release).
Distribution: Unknown.
Half-Life: 2–4 hr.
(CNS stimulation)
| ROUTE | ONSET | PEAK | DURATION |
|---|---|---|---|
| PO | unknown | 1–3 hr | 4–6 hr |
| PO-ER | unknown | 4–7 hr | 3–12 hr‡ |
| Transdermal | unknown | unknown | 12 hr |
‡Depends on formulation.
Contraindicated in:
Use Cautiously in:
History of substance use
;Continual use (may produce psychological dependence or physical addiction)
;CV: hypertension, palpitations, tachycardia, hypotension, peripheral vasculopathy, SUDDEN DEATH
Derm: contact sensitization (erythema, edema, papules, vesicles) (transdermal), erythema, loss of skin pigmentation (transdermal), rash
EENT: blurred vision, ↑intraocular pressure, teeth grinding
GI: anorexia, constipation, cramps, diarrhea, dry mouth, metallic taste, nausea, vomiting
GU: priapism
MS: RHABDOMYOLYSIS
Neuro: hyperactivity, insomnia, restlessness, tremor, akathisia, behavioral disturbances, dizziness, dyskinesia, hallucinations, headache, irritability, mania, thought disorder, tics, Tourette syndrome
Misc: fever, HYPERSENSITIVITY REACTIONS (INCLUDING ANAPHYLAXIS AND ANGIOEDEMA),
physical dependence
,psychological dependence
, toleranceDrug-drug:
Drug-Natural Products:
Drug-Food:
Attention-Deficit Hyperactivity Disorder
Narcolepsy
Assess for risk of abuse, misuse, or addiction prior to starting therapy and during therapy. Has high dependence and abuse or misuse potential. Misuse and abuse of CNS stimulants can result in overdose and death; this risk is ↑ with higher doses or unapproved methods of administration, such as snorting or injection. Tolerance to medication occurs rapidly; do not ↑ dose.
Lab Test Considerations:
Advise patient that methylphenidate is a drug with known potential for abuse, misuse, and/or addiction. Store in safe place, protect it from theft, and never give to anyone other than the individual for whom it was prescribed.
methylphenidate (oral): Adhansia XR, Aptensio XR, Concerta, Cotempla XR-ODT, Jornay PM, Metadate CD, Methylin, Quillichew ER, Quillivant XR, Relexxii, Ritalin, Ritalin LA,
methylphenidate (transdermal): Daytrana
NDC Code
