section name header

Pronunciation ⬇

LIR-a-GLOO-tide

Classifications ⬆ ⬇

Therapeutic Classification: antidiabetics

Pharmacologic Classification: glucagon like peptide 1 glp 1 receptor agonists

Indications ⬆ ⬇

REMS


Action ⬆ ⬇

  • Acts as an acylated human glucagon-like peptide-1 (GLP-1, an incretin) receptor agonist; increases intracellular cyclic AMP leading to insulin release when glucose is elevated, which then subsides as blood glucose decreases toward euglycemia. Also decreases glucagon secretion and delays gastric emptying. Also helps to suppress appetite, leading to decreased caloric intake.
Therapeutic effects:
  • Improved glycemic control.
  • Reduction in body weight.
  • Reduction in cardiovascular death, nonfatal MI, or nonfatal stroke.

Pharmacokinetics ⬆ ⬇

Absorption: 55% absorbed following SUBQ injection.

Distribution: Unknown.

Protein Binding: >98%.

Metabolism/Excretion: Endogenously metabolized.

Half-Life: 13 hr.

Time/Action Profile ⬆ ⬇

ROUTEONSETPEAKDURATION
SUBQwithin 4 wk‡
within 2 wk‡
8 wk‡
40 wk‡
unknown‡‡

‡↓in A1c.

‡↓in body weight.

Contraind./Precautions ⬆ ⬇

Contraindicated in:

Use Cautiously in:

Adv. Reactions/Side Effects ⬆ ⬇

Interactions ⬆ ⬇

Drug-drug:

Route/Dosage ⬆ ⬇

Victoza

Saxenda

Availability ⬆ ⬇

(Generic available)

Assessment ⬆ ⬇

Lab Test Considerations:

Implementation ⬆ ⬇

Patient/Family Teaching ⬆ ⬇

Evaluation/Desired Outcomes ⬆ ⬇

US Brand Names ⬆ ⬇

Saxenda, Victoza

Code ⬆

NDC Code