• Y-Site Compatibility:
  • bivalirudin

IV Administration:

• Anticoagulant therapy is usually administered concurrently, unless contraindicated, to ↓ risk of pulmonary or systemic embolism.
  • Administer via peripheral infusion during acute dose ranging and by chronic continuous infusion via central venous catheter using a programmable ambulatory infusion pump for chronic administration.
  • Use an infusion set with an in-line 0.22-micron filter. The infusion pump should be able to adjust infusion rates in 2 ng/kg/min increments, be accurate to ±6% of the programmed rate, and be positive pressure-driven with intervals between pulses ≤3 min. The reservoir should be made of polyvinyl chloride, polypropylene, or glass.
  • Do not mix with other parenteral medications or solutions prior to or during administration.
• Continuous Infusion: Reconstitution: For either the 3000- or 5000-ng/mL concentration, dissolve contents of one 0.5-mg vial with 5 mL sterile water or 0.9% NaCl injection. Withdraw 3 mL for the 3000-ng/mL concentration and the entire vial contents for the 5000-ng/mL concentration and add to a sufficient quantity of identical diluent to make a total of 100 mL.Concentration: 3000 or 5000 ng/mL. Reconstitution: For the 10,000-ng/mL concentration, dissolve contents of two 0.5-mg vials each with 5 mL sterile water or 0.9% NaCl injection. Withdraw entire vial contents, and add to a sufficient quantity of identical diluent to make a total of 100 mL.Concentration: 10,000 ng/mL.Diluent: For the 15,000-ng/mL concentration, dissolve contents of a 1.5-mg vial with 5 mL sterile water or 0.9% NaCl injection. Withdraw entire vial contents, and add to a sufficient quantity of identical diluent to make a total of 100 mL. Concentration: 15,000 ng/mL. Diluent: For the 30,000 ng/mL concentration, dissolve contents of two 1.5-mg vials each with 5 mL sterile water or 0.9% NaCl injection. Withdraw entire vial contents, and add to a sufficient quantity of identical diluent to make a total of 100 mL. Concentration: 30,000 ng/mL.
  • May require more than one solution strength during acute dose ranging. Usually 3000 and 10,000 ng/mL are used.
  • Protect unopened vials and reconstituted solutions from light. Reconstituted solution is stable for 8 hr at room temperature or 48 hr if refrigerated. Do not freeze.
• Rate: Infusion rate usually ranges from 2–16 ng/kg/min.