daptomycin

Therapeutic Classification: anti-infectives

Pharmacologic Classification: cyclic lipopeptide antibacterial agents

REMS

Complicated skin and skin structure infections caused by gram-positive bacteria.
Staphylococcus aureus bacteremia, including right-sided infective endocarditis caused by methicillin-susceptible and methicillin-resistant strains (in adults).
Staphylococcus aureus bacteremia (in pediatric patients).

Causes rapid depolarization of membrane potential following binding to bacterial membrane; this results in inhibition of protein, DNA, and RNA synthesis.

Therapeutic effects:

Death of bacteria with resolution of infection.

Spectrum:

Active against Staphylococcus aureus (including methicillin-resistant strains), Streptococcus pyogenes, Streptococcus agalactiae, some Streptococcus dysgalactiae, and Enterococcus faecalis (vancomycin-susceptible strains).

Absorption: IV administration results in complete bioavailability.

Distribution: Unknown.

Protein Binding: 92%.

Metabolism/Excretion: Metabolism not known; mostly excreted by kidneys.

Half-Life: 8.1 hr.

ROUTE	ONSET	PEAK	DURATION
IV	rapid	end of infusion	24 hr

Contraindicated in:

Hypersensitivity.

Use Cautiously in:

Severe renal impairment (↓ dose);
Moderate to severe renal impairment (may have ↓ clinical response);
OB: Safety not established in pregnancy;
Lactation: Safety not established in breastfeeding;
Pedi: Children <1 yr (↑ risk of muscular, neuromuscular, and CNS effects; avoid use);
Geri: Older adults may have ↓ clinical response with ↑ risk of adverse reactions.

CV: hypertension, hypotension

Derm: DRUG RASH WITH EOSINOPHILIA AND SYSTEMIC SYMPTOMS (DRESS), pruritus, rash

GI: ↑liver enzymes, CLOSTRIDIOIDES DIFFICILE-ASSOCIATED DIARRHEA (CDAD), constipation, diarrhea, nausea, vomiting

GU: renal impairment

Hemat: anemia

Local: injection site reactions

MS: ↑CK

Neuro: dizziness

Resp: dyspnea, EOSINOPHILIC PNEUMONIA

Misc: ANGIOEDEMA, fever

Drug-drug:

Tobramycin may ↑ levels and risk of toxicity.
HMG-CoA reductase inhibitors may ↑ risk of myopathy; consider discontinuing statin before starting daptomycin; if used with statin, closely monitor CK levels.

Complicated Skin/Skin Structure Infections

IV (Adults ): 4 mg/kg every 24 hr for 7–14 days.
IV (Children 12–17 yr): 5 mg/kg every 24 hr for up to 14 days.
IV (Children 7–11 yr): 7 mg/kg every 24 hr for up to 14 days.
IV (Children 2–6 yr): 9 mg/kg every 24 hr for up to 14 days.
IV (Children 1–<2 yr): 10 mg/kg every 24 hr for up to 14 days.

Renal Impairment

IV (Adults ): CCr <30 mL/min: 4 mg/kg every 48 hr for 7–14 days; Hemodialysis and CAPD: 4 mg/kg every 48 hr for 7–14 days, with dose administered after hemodialysis on hemodialysis days.

Staphylococcus aureus Bacteremia/Right-Sided Infective Endocarditis

IV (Adults ): 6 mg/kg every 24 hr for 2–6 wk.

Renal Impairment

IV (Adults ): CCr <30 mL/min: 6 mg/kg every 48 hr for 2–6 wk; Hemodialysis and CAPD: 6 mg/kg every 48 hr for 2–6 wk, with dose administered after hemodialysis on hemodialysis days.

Staphylococcus aureus Bacteremia

IV (Children 12–17 yr): 7 mg/kg every 24 hr for up to 42 days.
IV (Children 7–11 yr): 9 mg/kg every 24 hr for up to 42 days.
IV (Children 1–6 yr): 12 mg/kg every 24 hr for up to 42 days.

(Generic available)

Lyophilized powder for injection: 350 mg/vial; 500 mg/vial
Premixed infusion: 350 mg/50 mL 0.9% NaCl; 500 mg/50 mL 0.9% NaCl; 700 mg/100 mL 0.9% NaCl; 1000 mg/100 mL 0.9% NaCl

Assess for infection (vital signs; appearance of wound, sputum, urine, and stool; WBC) at beginning of and during therapy.
Monitor bowel function. Diarrhea, abdominal cramping, fever, and bloody stools should be reported to health care professional promptly as a sign of CDAD. May begin up to several wk following cessation of therapy.
Monitor for signs and symptoms of eosinophilic pneumonia (new onset or worsening fever, dyspnea, difficulty breathing, new infiltrates on chest imaging studies). Discontinue daptomycin if symptoms occur.
Monitor for signs and symptoms of DRESS (fever, rash, lymphadenopathy, facial swelling), associated with involvement of other organ systems (hepatitis, nephritis, hematologic abnormalities, myocarditis, myositis) during therapy. May resemble an acute viral infection. Eosinophilia is often present. Discontinue therapy if signs occur.
Monitor for development of muscle pain or weakness, particularly of distal extremities. Discontinue daptomycin in patients with unexplained signs and symptoms of myopathy in conjunction with CK >1000 units/L, or in patients without reported symptoms who have marked elevations in CK >2000 units/L. Consider temporarily suspending agents associated with rhabdomyolysis (HMG-CoA reductase inhibitors) in patients receiving daptomycin.
Monitor for signs and symptoms of peripheral neuropathy during use.

Lab Test Considerations:

Monitor CK weekly, more frequently in patients with unexplained ↑. Discontinue daptomycin if CK >1000 units/L and signs and symptoms of myopathy occur. In patients with renal impairment, monitor both renal function and CK more frequently.
- May cause false ↑ PT and INR.
- Monitor renal function before and periodically during therapy. If new or worsening renal impairment occurs, evaluate renal function. If tubulointerstitial nephritis is suspected, discontinue daptomycin and begin treatment.

Do not confuse daptomycin with dactinomycin.

IV Administration:

IV Push: Reconstitution: Reconstitute 500-mg vial with 10 mL of 0.9% NaCl inserted toward wall of vial. Rotate vial gently to wet powder. Allow to stand for 10 min undisturbed. Swirl vial gently to completely reconstitute solution. Reconstituted vials are stable for 12 hr at room temperature or 48 hr if refrigerated. Concentration: 50 mg/mL.
Rate: Administer over 2 min (for adults only).
Intermittent Infusion: Adults and children ≥7 yr:Diluent: Dilute contents of reconstituted vial in 50 mL of 0.9% NaCl. Solution is stable for 12 hr at room temperature or 48 hr if refrigerated. Do not administer solutions that are cloudy or contain a precipitate.
Rate: Infuse over 30 min.
Intermittent Infusion: Children 1–6 yr:Diluent: Dilute contents of reconstituted vial in 25 mL of 0.9% NaCl.
Rate: Infuse over 60 min.
Y-Site Compatibility:
- amifostine
- amikacin
- aminocaproic acid
- aminophylline
- amiodarone
- amphotericin B liposomal
- ampicillin
- ampicillin/sulbactam
- argatroban
- arsenic trioxide
- atracurium
- azithromycin
- aztreonam
- bivalirudin
- bleomycin
- bumetanide
- buprenorphine
- busulfan
- butorphanol
- calcium chloride
- calcium gluconate
- cangrelor
- carboplatin
- carmustine
- caspofungin
- cefazolin
- cefepime
- cefotaxime
- cefotetan
- cefoxitin
- ceftazidime
- ceftazidime/avibactam
- ceftolozane/tazobactam
- ceftriaxone
- cefuroxime
- chloramphenicol
- chlorpromazine
- ciprofloxacin
- cisatracurium
- cisplatin
- clindamycin
- cyclophosphamide
- cyclosporine
- dacarbazine
- dactinomycin
- daunorubicin
- dexamethasone
- dexmedetomidine
- dexrazoxane
- digoxin
- diltiazem
- diphenhydramine
- dobutamine
- docetaxel
- dopamine
- doxorubicin hydrochloride
- doxorubicin liposomal
- doxycycline
- droperidol
- enalaprilat
- ephedrine
- epinephrine
- epirubicin
- eptifibatide
- ertapenem
- erythromycin
- esmolol
- etoposide
- etoposide phosphate
- famotidine
- fentanyl
- fluconazole
- fludarabine
- fluorouracil
- foscarnet
- fosphenytoin
- furosemide
- ganciclovir
- gentamicin
- glycopyrrolate
- granisetron
- haloperidol
- heparin
- hydralazine
- hydrocortisone
- hydromorphone
- idarubicin
- ifosfamide
- insulin, regular
- irinotecan
- isavuconazonium
- isoproterenol
- ketorolac
- labetalol
- letermovir
- leucovorin calcium
- levofloxacin
- lidocaine
- linezolid
- lorazepam
- magnesium sulfate
- mannitol
- melphalan
- meperidine
- meropenem
- mesna
- methadone
- methylprednisolone
- metoclopramide
- metoprolol
- midazolam
- milrinone
- mitoxantrone
- morphine
- moxifloxacin
- mycophenolate
- nafcillin
- nalbuphine
- naloxone
- nicardipine
- nitroprusside
- norepinephrine
- octreotide
- ondansetron
- oxaliplatin
- oxytocin
- paclitaxel
- palonosetron
- pamidronate
- pemetrexed
- pentamidine
- phenobarbital
- phentolamine
- phenylephrine
- piperacillin/tazobactam
- posaconazole
- potassium acetate
- potassium chloride
- potassium phosphate
- procainamide
- prochlorperazine
- promethazine
- propranolol
- rifampin
- rocuronium
- sodium acetate
- sodium bicarbonate
- sodium phosphate
- succinylcholine
- sufentanil
- tacrolimus
- tedizolid
- theophylline
- thiotepa
- tigecycline
- tirofiban
- tobramycin
- topotecan
- trimethoprim/sulfamethoxazole
- vasopressin
- vecuronium
- verapamil
- vinblastine
- vincristine
- vinorelbine
- voriconazole
- zidovudine
- zoledronic acid
Y-Site Incompatibility:
- acyclovir
- alemtuzumab
- allopurinol
- amphotericin B lipid complex
- blinatumomab
- cytarabine
- D5W
- dantrolene
- gemcitabine
- gemtuzumab ozogamicin
- imipenem/cilastatin
- meropenem/vaborbactam
- methotrexate
- metronidazole
- minocycline
- mitomycin
- nitroglycerin
- pantoprazole
- pentobarbital
- phenytoin
- plazomicin
- remifentanil
- streptozocin
- sufentanil
- sulbactam/durlobactam
- thiopental
- vancomycin

Explain the purpose and side effects of daptomycin. Advise patient to read Medication Guide before starting and periodically during therapy in case of changes.
Instruct patient to notify health care professional if fever and diarrhea develop, especially if stool contains blood, pus, or mucus. Advise patient not to treat diarrhea without consulting health care professional.
May cause dizziness. Caution patient to avoid driving or other activities requiring alertness until response to medication is known.
Advise patient to notify health care professional immediately if weakness, numbness, or tingling in forearms and lower legs or signs and symptoms of eosinophilic pneumonia or DRESS occur.
Advise patient to notify health care professional of all Rx or OTC medications, vitamins, or herbal products being taken and to consult with health care professional before taking other medications. Instruct patient to avoid using HMG-CoA reductase inhibitors (cholesterol-lowering agents such as atorvastatin, fluvastatin, lovastatin, pitavastatin, simvastatin) unless approved by health care professional, as concurrent use with daptomycin may ↑ risk of myopathy.
Rep: Advise women of reproductive potential to notify health care professional if pregnancy is planned or suspected or if breastfeeding. Monitor breastfed infants exposed to daptomycin for GI disturbances.

Resolution of the signs and symptoms of infection. Length of time for complete resolution depends on the organism and site of infection.

NDC Code

0143- Hikma Pharmaceuticals USA Inc.
- 0143-9378- Daptomycin
  - 0143-9378-01- 1 VIAL, SINGLE-DOSE in 1 CARTON (0143-9378-01) / 10 mL in 1 VIAL, SINGLE-DOSE

0409- Hospira, Inc.
- 0409-0120- Daptomycin
  - 0409-0120-01- 1 VIAL, SINGLE-DOSE in 1 CARTON (0409-0120-01) / 7 mL in 1 VIAL, SINGLE-DOSE

0409- Hospira, Inc.
- 0409-0122- Daptomycin
  - 0409-0122-01- 1 VIAL, SINGLE-DOSE in 1 CARTON (0409-0122-01) / 10 mL in 1 VIAL, SINGLE-DOSE

14335- Hainan Poly Pharm., Co., Ltd.
- 14335-120- daptomycin
  - 14335-120-01- 20 mL in 1 VIAL, SINGLE-DOSE (14335-120-01)

16714- NorthStar RxLLC
- 16714-892- Daptomycin
  - 16714-892-01- 1 VIAL, SINGLE-DOSE in 1 CARTON (16714-892-01) / 15 mL in 1 VIAL, SINGLE-DOSE

16729- Accord Healthcare, Inc.
- 16729-434- Daptomycin
  - 16729-434-05- 1 VIAL in 1 CARTON (16729-434-05) / 7 mL in 1 VIAL

16729- Accord Healthcare, Inc.
- 16729-434- Daptomycin
  - 16729-434-45- 10 VIAL in 1 CARTON (16729-434-45) / 7 mL in 1 VIAL

16729- Accord Healthcare Inc.
- 16729-435- DAPTOMYCIN
  - 16729-435-05- 1 VIAL, SINGLE-DOSE in 1 CARTON (16729-435-05) / 10 mL in 1 VIAL, SINGLE-DOSE

17337- Olon SpA
- 17337-0261-
  - 17337-0261-1- 1.5 kg in 1 BOTTLE, GLASS (17337-0261-1)

17337- Olon SpA
- 17337-0261-
  - 17337-0261-2- 1 CONTAINER in 1 BOX (17337-0261-2) / 1 BAG in 1 CONTAINER / 1 BAG in 1 BAG / 1 BOTTLE, GLASS in 1 BAG / 4 kg in 1 BOTTLE, GLASS

25021- Sagent Pharmaceuticals
- 25021-174- daptomycin
  - 25021-174-15- 1 VIAL in 1 CARTON (25021-174-15) / 10 mL in 1 VIAL

25021- Sagent Pharmaceuticals
- 25021-174- daptomycin
  - 25021-174-16- 10 VIAL in 1 CARTON (25021-174-16) / 10 mL in 1 VIAL

25021- Sagent Pharmaceuticals
- 25021-179- Daptomycin
  - 25021-179-15- 1 VIAL in 1 CARTON (25021-179-15) / 7 mL in 1 VIAL

25021- Sagent Pharmaceuticals
- 25021-179- Daptomycin
  - 25021-179-16- 10 VIAL in 1 CARTON (25021-179-16) / 7 mL in 1 VIAL

25021- Sagent Pharmaceuticals
- 25021-179- Daptomycin
  - 25021-179-66- 1 VIAL in 1 CARTON (25021-179-66) / 7 mL in 1 VIAL

25021- Sagent Pharmaceuticals
- 25021-179- Daptomycin
  - 25021-179-67- 10 VIAL in 1 CARTON (25021-179-67) / 7 mL in 1 VIAL

31722- Camber Pharmaceuticals Inc.
- 31722-102- Daptomycin
  - 31722-102-10- 1 VIAL, SINGLE-DOSE in 1 CARTON (31722-102-10) / 10 mL in 1 VIAL, SINGLE-DOSE

31722- Camber Pharmaceuticals, Inc.
- 31722-215- Daptomycin
  - 31722-215-01- 1 VIAL, SINGLE-DOSE in 1 CARTON (31722-215-01) / 7 mL in 1 VIAL, SINGLE-DOSE

31722- Camber Pharmaceuticals, Inc.
- 31722-215- Daptomycin
  - 31722-215-10- 10 VIAL, SINGLE-DOSE in 1 CARTON (31722-215-10) / 7 mL in 1 VIAL, SINGLE-DOSE

31722- Camber Pharmaceuticals, Inc.
- 31722-216- Daptomycin
  - 31722-216-01- 1 VIAL, SINGLE-DOSE in 1 CARTON (31722-216-01) / 10 mL in 1 VIAL, SINGLE-DOSE

42513- Livzon Group Fuzhou Fuxing Pharmaceutical Co., Ltd.
- 42513-0004-
  - 42513-0004-1- 5 CONTAINER in 1 CARTON (42513-0004-1) / 5 kg in 1 CONTAINER

42513- Livzon Group Fuzhou Fuxing Pharmaceutical Co., Ltd.
- 42513-0004-
  42513-0004-2- 1 BOTTLE in 1 BAG (42513-0004-2) / 1 BAG in 1 BOTTLE / 3 kg in 1 BAG

42513- Livzon Group Fuzhou Fuxing Pharmaceutical Co., Ltd.
- 42513-0004-
  42513-0004-3- 1 BOTTLE in 1 BAG (42513-0004-3) / 1 BAG in 1 BOTTLE / 1 kg in 1 BAG

42513- Livzon Group Fuzhou Fuxing Pharmaceutical Co., Ltd.
- 42513-0004-
  42513-0004-4- 1 BOTTLE in 1 BAG (42513-0004-4) / 1 BAG in 1 BOTTLE / 10 kg in 1 BAG

42513- Livzon Group Fuzhou Fuxing Pharmaceutical Co., Ltd.
- 42513-0015-
  42513-0015-1- 1 BAG in 1 CARTON (42513-0015-1) / 1 BOTTLE in 1 BAG / 1 kg in 1 BOTTLE

42513- Livzon Group Fuzhou Fuxing Pharmaceutical Co., Ltd.
- 42513-0015-
  42513-0015-2- 1 BAG in 1 CARTON (42513-0015-2) / 1 BOTTLE in 1 BAG / 4 kg in 1 BOTTLE

42513- Livzon Group Fuzhou Fuxing Pharmaceutical Co., Ltd.
- 42513-0015-
  42513-0015-3- 1 BOTTLE in 1 BAG (42513-0015-3) / 1 kg in 1 BOTTLE

42513- Livzon Group Fuzhou Fuxing Pharmaceutical Co., Ltd.
- 42513-0015-
  42513-0015-4- 1 BOTTLE in 1 BAG (42513-0015-4) / 4 kg in 1 BOTTLE

42658- Hisun Pharmaceuticals USA, Inc.
- 42658-011- daptomycin
  42658-011-01- 1 VIAL, SINGLE-DOSE in 1 CARTON (42658-011-01) / 10 mL in 1 VIAL, SINGLE-DOSE

43598- Dr.Reddy's Laboratories Inc.,
- 43598-413- Daptomycin
  - 43598-413-11- 1 VIAL, SINGLE-DOSE in 1 CARTON (43598-413-11) / 10 mL in 1 VIAL, SINGLE-DOSE

43598- Dr. Reddy's Laboratories Inc.,
- 43598-476- Daptomycin
  - 43598-476-11- 1 VIAL, SINGLE-DOSE in 1 CARTON (43598-476-11) / 7 mL in 1 VIAL, SINGLE-DOSE

43598- Dr. Reddy's Laboratories Inc.,
- 43598-476- Daptomycin
  - 43598-476-58- 10 VIAL, SINGLE-DOSE in 1 CARTON (43598-476-58) / 7 mL in 1 VIAL, SINGLE-DOSE

51187- Hisun Pharmaceutical (Hangzhou) Co., Ltd.
- 51187-0002-
  - 51187-0002-5- 2 kg in 1 DRUM (51187-0002-5)

52946- ACS Dobfar S.p.A.
- 52946-0500-
  52946-0500-0- 25 kg in 1 CONTAINER (52946-0500-0)

55150- Eugia US LLC
- 55150-344- DAPTOMYCIN
  55150-344-01- 1 VIAL, SINGLE-DOSE in 1 CARTON (55150-344-01) / 10 mL in 1 VIAL, SINGLE-DOSE

57885- Chongqing Daxin Pharmaceutical Co. Ltd.
- 57885-0011-
  - 57885-0011-2- 1 kg in 1 BAG (57885-0011-2)

60505- APOTEX CORP.
- 60505-6229- Daptomycin
  60505-6229-4- 1 VIAL, SINGLE-USE in 1 CARTON (60505-6229-4) / 10 mL in 1 VIAL, SINGLE-USE

63323- Fresenius Kabi USA, LLC
- 63323-371- Daptomycin
  - 63323-371-10- 1 VIAL, SINGLE-DOSE in 1 CARTON (63323-371-10) / 10 mL in 1 VIAL, SINGLE-DOSE

63323- Fresenius Kabi USA, LLC
- 63323-371- Daptomycin
  - 63323-371-19- 1 VIAL, SINGLE-DOSE in 1 CARTON (63323-371-19) / 10 mL in 1 VIAL, SINGLE-DOSE

65897- Hangzhou Zhongmei Huadong Pharmaceutical Co., Ltd
- 65897-1011-
  - 65897-1011-1- 2 kg in 1 CAN (65897-1011-1)

65897- Hangzhou Zhongmei Huadong Pharmaceutical Co., Ltd.
- 65897-2011-
  65897-2011-1- 1 kg in 1 CAN (65897-2011-1)

67184- Qilu Pharmaceutical Co., Ltd.
- 67184-0549- Daptomycin
  67184-0549-1- 1 VIAL, SINGLE-USE in 1 CARTON (67184-0549-1) / 10 mL in 1 VIAL, SINGLE-USE

67254- Zhejiang Medicine Co., Ltd. Xinchang Pharmaceutical Factory
- 67254-515-
  - 67254-515-01- .5 kg in 1 DRUM (67254-515-01)

67254- Zhejiang Medicine Co., Ltd. Xinchang Pharmaceutical Factory
- 67254-515-
  67254-515-02- 1 kg in 1 DRUM (67254-515-02)

67254- Zhejiang Medicine Co., Ltd. Xinchang Pharmaceutical Factory
- 67254-515-
  67254-515-03- 2 kg in 1 DRUM (67254-515-03)

67254- Zhejiang Medicine Co., Ltd. Xinchang Pharmaceutical Factory
- 67254-515-
  67254-515-04- 3 kg in 1 DRUM (67254-515-04)

67254- Zhejiang Medicine Co., Ltd. Xinchang Pharmaceutical Factory
- 67254-515-
  67254-515-05- 4 kg in 1 DRUM (67254-515-05)

67254- Zhejiang Medicine Co., Ltd. Xinchang Pharmaceutical Factory
- 67254-515-
  67254-515-06- 5 kg in 1 DRUM (67254-515-06)

67254- Zhejiang Medicine Co., Ltd. Xinchang Pharmaceutical Factory
- 67254-515-
  67254-515-07- .2 kg in 1 DRUM (67254-515-07)

67254- Zhejiang Medicine Co., Ltd. Xinchang Pharmaceutical Factory
- 67254-515-
  67254-515-08- .3 kg in 1 DRUM (67254-515-08)

67254- Zhejiang Medicine Co., Ltd. Xinchang Pharmaceutical Factory
- 67254-515-
  67254-515-09- .4 kg in 1 DRUM (67254-515-09)

67254- Zhejiang Medicine Co., Ltd. Xinchang Pharmaceutical Factory
- 67254-515-
  67254-515-10- .6 kg in 1 DRUM (67254-515-10)

67254- Zhejiang Medicine Co., Ltd. Xinchang Pharmaceutical Factory
- 67254-515-
  67254-515-11- .7 kg in 1 DRUM (67254-515-11)

67254- Zhejiang Medicine Co., Ltd. Xinchang Pharmaceutical Factory
- 67254-515-
  67254-515-12- .8 kg in 1 DRUM (67254-515-12)

67254- Zhejiang Medicine Co., Ltd. Xinchang Pharmaceutical Factory
- 67254-515-
  67254-515-13- .9 kg in 1 DRUM (67254-515-13)

67457- Mylan Institutional LLC
- 67457-813- daptomycin
  67457-813-50- 1 VIAL, SINGLE-DOSE in 1 CARTON (67457-813-50) / 10 mL in 1 VIAL, SINGLE-DOSE

67457- Mylan Institutional LLC
- 67457-941- daptomycin
  - 67457-941-15- 1 VIAL, SINGLE-DOSE in 1 CARTON (67457-941-15) / 10 mL in 1 VIAL, SINGLE-DOSE

68001- BluePoint Laboratories
- 68001-376- Daptomycin
  - 68001-376-68- 1 VIAL, SINGLE-DOSE in 1 CARTON (68001-376-68) / 10 mL in 1 VIAL, SINGLE-DOSE

68225- Patheon Italia S.p.A
- 68225-052-
  - 68225-052-01- 10368 VIAL in 1 CONTAINER (68225-052-01) / 10 mL in 1 VIAL

68225- Patheon Italia S.p.A.
- 68225-082-
  68225-082-01- 96 BOX in 1 CONTAINER (68225-082-01) / 108 VIAL, SINGLE-USE in 1 BOX / 10 mL in 1 VIAL, SINGLE-USE

69097- Cipla USA Inc.
- 69097-807- Daptomycin
  69097-807-37- 1 VIAL, SINGLE-DOSE in 1 CARTON (69097-807-37) / 10 mL in 1 VIAL, SINGLE-DOSE

69097- Cipla USA Inc.
- 69097-850- daptomycin
  - 69097-850-67- 1 VIAL in 1 CARTON (69097-850-67) / 7 mL in 1 VIAL

70377- Biocon Pharma Inc.
- 70377-093- Daptomycin
  - 70377-093-91- 1 VIAL, SINGLE-USE in 1 CARTON (70377-093-91) / 10 mL in 1 VIAL, SINGLE-USE

70436- Slate Run Pharmaceuticals, LLC
- 70436-033- daptomycin
  - 70436-033-80- 20 mL in 1 VIAL, SINGLE-DOSE (70436-033-80)

70511- MAIA Pharmaceuticals, Inc.
- 70511-181- Daptomycin
  - 70511-181-84- 10 VIAL, SINGLE-DOSE in 1 CARTON (70511-181-84) / 1 INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION in 1 VIAL, SINGLE-DOSE (70511-181-10)

70511- MAIA Pharmaceuticals, Inc.
- 70511-182- Daptomycin
  - 70511-182-84- 10 VIAL, SINGLE-DOSE in 1 CARTON (70511-182-84) / 1 INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION in 1 VIAL, SINGLE-DOSE (70511-182-15)

70594- Xellia Pharmaceuticals USA LLC
- 70594-034- Daptomycin
  - 70594-034-01- 1 VIAL, SINGLE-USE in 1 CARTON (70594-034-01) / 10 mL in 1 VIAL, SINGLE-USE

70594- Xellia Pharmaceuticals USA LLC
- 70594-034- Daptomycin
  - 70594-034-02- 1 VIAL, SINGLE-USE in 1 CARTON (70594-034-02) / 10 mL in 1 VIAL, SINGLE-USE

70594- Xellia Pharmaceuticals USA LLC
- 70594-053- Daptomycin
  - 70594-053-01- 1 VIAL, SINGLE-USE in 1 CARTON (70594-053-01) / 7 mL in 1 VIAL, SINGLE-USE

70594- Xellia Pharmaceuticals USA LLC
- 70594-060- Daptomycin
  - 70594-060-01- 1 VIAL, SINGLE-USE in 1 CARTON (70594-060-01) / 10 mL in 1 VIAL, SINGLE-USE

70594- Xellia Pharmaceuticals USA LLC
- 70594-066- Daptomycin
  - 70594-066-01- 1 VIAL, SINGLE-USE in 1 CARTON (70594-066-01) / 7 mL in 1 VIAL, SINGLE-USE

71288- Meitheal Pharmaceuticals Inc.
- 71288-016- DAPTOMYCIN
  - 71288-016-15- 1 VIAL, SINGLE-DOSE in 1 CARTON (71288-016-15) / 10 mL in 1 VIAL, SINGLE-DOSE

71288- Meitheal Pharmaceuticals Inc.
- 71288-016- DAPTOMYCIN
  - 71288-016-91- 1 VIAL, SINGLE-DOSE in 1 CARTON (71288-016-91) / 10 mL in 1 VIAL, SINGLE-DOSE

71288- Meitheal Pharmaceuticals Inc.
- 71288-016- DAPTOMYCIN
  - 71288-016-95- 1 VIAL, SINGLE-DOSE in 1 CARTON (71288-016-95) / 10 mL in 1 VIAL, SINGLE-DOSE

71288- Meitheal Pharmaceuticals Inc.
- 71288-017- DAPTOMYCIN
  - 71288-017-15- 1 VIAL, SINGLE-DOSE in 1 CARTON (71288-017-15) / 7 mL in 1 VIAL, SINGLE-DOSE

71288- Meitheal Pharmaceuticals Inc.
- 71288-017- DAPTOMYCIN
  - 71288-017-91- 1 VIAL, SINGLE-DOSE in 1 CARTON (71288-017-91) / 7 mL in 1 VIAL, SINGLE-DOSE

71839- BE Pharmaceuticals Inc.
- 71839-107- daptomycin
  - 71839-107-01- 1 VIAL, SINGLE-DOSE in 1 CARTON (71839-107-01) / 10 mL in 1 VIAL, SINGLE-DOSE

71839- BE Pharmaceuticals Inc.
- 71839-108- daptomycin
  - 71839-108-01- 1 VIAL in 1 CARTON (71839-108-01) / 7 mL in 1 VIAL

71839- BE Pharmaceuticals Inc.
- 71839-108- daptomycin
  - 71839-108-10- 10 VIAL in 1 CARTON (71839-108-10) / 7 mL in 1 VIAL

72572- Civica, Inc.
- 72572-100- Daptomycin
  - 72572-100-01- 1 VIAL, SINGLE-USE in 1 CARTON (72572-100-01) / 7 mL in 1 VIAL, SINGLE-USE

72572- Civica, Inc.
- 72572-102- Daptomycin
  - 72572-102-01- 1 VIAL, SINGLE-USE in 1 CARTON (72572-102-01) / 10 mL in 1 VIAL, SINGLE-USE

72603- NorthStar RxLLC
- 72603-147- Daptomycin
  - 72603-147-01- 1 VIAL, SINGLE-DOSE in 1 CARTON (72603-147-01) / 7 mL in 1 VIAL, SINGLE-DOSE

72603- NorthStar RxLLC
- 72603-152- Daptomycin
  - 72603-152-01- 1 VIAL, SINGLE-DOSE in 1 CARTON (72603-152-01) / 10 mL in 1 VIAL, SINGLE-DOSE

73402- Zhejiang Changhai Pharmaceuticals Co., Ltd.
- 73402-111-
  - 73402-111-01- 5 kg in 1 DRUM (73402-111-01)

83090- Sintetica US LLC
- 83090-011- daptomycin
  83090-011-01- 1 VIAL, SINGLE-DOSE in 1 CARTON (83090-011-01) / 10 mL in 1 VIAL, SINGLE-DOSE

83634- Avenacy Inc.
- 83634-107- Daptomycin
  - 83634-107-20- 1 VIAL in 1 CARTON (83634-107-20) / 10 mL in 1 VIAL

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Pronunciation ⬇

Classifications ⬆ ⬇

Indications ⬆ ⬇

Action ⬆ ⬇

Pharmacokinetics ⬆ ⬇

Time/Action Profile ⬆ ⬇

Contraind./Precautions ⬆ ⬇

Adv. Reactions/Side Effects ⬆ ⬇

Interactions ⬆ ⬇

Route/Dosage ⬆ ⬇

Availability ⬆ ⬇

Assessment ⬆ ⬇

Implementation ⬆ ⬇

Patient/Family Teaching ⬆ ⬇

Evaluation/Desired Outcomes ⬆ ⬇

US Brand Names ⬆ ⬇

Code ⬆