phentermine

FEN-ter-meen

Therapeutic Classification: weight control agents

Pharmacologic Classification: appetite suppressants

REMS

Short-term treatment of obesity in conjunction with other interventions (dietary restriction, exercise); used to produce and maintain weight loss in patients with a BMI ≥30 kg/m² or ≥27 kg/m² in the presence of other risk factors (diabetes, hypertension, hyperlipidemia).

Decreases hunger by altering the chemical control of nerve impulse transmission in the appetite control center of the hypothalamus.

Therapeutic effects:

Appetite suppression with resultant weight loss.

Absorption: Unknown.

Distribution: Unknown.

Metabolism/Excretion: Metabolized by the liver.

Half-Life: 19–24 hr.

(appetite suppression)

ROUTE	ONSET	PEAK	DURATION
PO	unknown	unknown	4 hr‡

‡For 8-mg tablets, increase to 12–14 hr for 30-mg capsules or 37.5-mg tablets.

Contraindicated in:

Hypersensitivity or known intolerance to sympathomimetic amines or tartrazine;
Cardiovascular disease;
Hyperthyroidism;
Uncontrolled hypertension;
History of drug abuse;
Agitation;
Glaucoma;
Concurrent or recent (within 14 days) MAO inhibitor therapy;
Concurrent SSRI antidepressants;
OB: Pregnancy;
Lactation: Lactation.

Use Cautiously in:

Diabetes mellitus;
Concurrent use of other weight-loss drugs;
Pedi: Children ≤16 yr (safety and effectiveness not established).

CV: hypertension, palpitations, tachycardia, VALVULAR ABNORMALITIES

EENT: blurred vision

GI: constipation, diarrhea, dry mouth, nausea, unpleasant taste, vomiting

GU: changes in libido, erectile dysfunction

Neuro: CNS stimulation, confusion, dizziness, dysphoria, euphoria, headache, insomnia, mental depression, restlessness

Resp: PULMONARY HYPERTENSION

Drug-drug:

Concurrent use with MAO inhibitors may result in hypertensive crisis and is contraindicated; do not use within 14 days of MAO inhibitors.
↑risk of adverse CNS events with alcohol.
Concurrent use with SSRI antidepressants is not recommended.
May ↓ insulin or oral hypoglycemic requirements in patients with diabetes.
Topiramate may ↑ levels and risk of toxicity.

PO (Adults and Children >16 yr): Tablets (except Lomaira), capsules, or orally disintegrating tablets: 15–37.5 mg once daily; Lomaira: 8 mg 3 times daily.

(Generic available)

Tablets (Adipex-P): 37.5 mg
Tablets (Lomaira): 8 mg
Orally disintegrating tablets: 15 mg; 30 mg; 37.5 mg
Capsules: 15 mg; 30 mg; 37.5 mg
In combination with: topiramate (Qsymia). See Appendix [not included in this PDA edition]

Monitor weight and waist circumference every mo for first 3 mo, then every 3 mo. Adjust concurrent medications (antihypertensives, antidiabetics, lipid-lowering agents) as needed.
Monitor for CNS effects (delirium, mania, psychosis).
Monitor BP and for pulmonary hypertension and valvular abnormalities (new-onset dyspnea, chest pain, syncope, lower extremity edema).
Monitor for development of tolerance (no longer effective in suppressing appetite).

PO: Avoid administering at nighttime. Cut scored tablets for half dose if needed. Administer before or 1–2 hr after breakfast. Administer Lomaira30 min before meals.
Orally disintegrating tablets: Administer in morning with or without food. Gently remove tablet with dry hands from bottle and immediately place on top of tongue; then swallow with or without water.

Explain purpose and side effects of medication to patient. Advise patient to read Patient Information before starting therapy. Instruct patient to take medication as directed. Take missed dose as soon as remembered. Do not take two doses at the same time. Tolerance to anorectic effect usually develops within a few wk. If this occurs, discontinue therapy. The recommended dose should not be exceeded. Medication may need to be discontinued gradually.
Advise patient to notify health care professional of all Rx or OTC medications, vitamins, or herbal products being taken and to consult health care professional before taking other medications.
Advise patient to adhere to a low-calorie diet and behavior modification counseling.
May cause drowsiness. Advise patient to avoid driving or other activities requiring alertness until response to medication is known.
Caution patient to avoid using alcohol or other CNS depressants with this medication.
Advise patient to notify health care professional immediately if chest pain, ↓ exercise tolerance, fainting, or swelling of the feet or lower legs occurs.
Caution patient not to use other weight loss products while taking phentermine.
Rep: May cause fetal harm. Advise females of reproductive potential to use effective contraception and avoid breastfeeding during therapy. Advise female patients to notify health care professional if pregnancy is planned or suspected.

Appetite suppression with resultant weight loss.

Adipex-P, Lomaira

Schedule IV (C-IV)

NDC Code

0792- Siegfried USA, LLC
- 0792-0344-
  - 0792-0344-00- 50 kg in 1 DRUM (0792-0344-00)

0792- Siegfried USA, LLC
- 0792-0345-
  - 0792-0345-00- 50 kg in 1 DRUM (0792-0345-00)

10702- KVK-TECH, INC.
- 10702-001- LOMAIRA
  - 10702-001-03- 30 TABLET in 1 BOTTLE (10702-001-03)

10702- KVK-TECH, INC.
- 10702-001- LOMAIRA
  - 10702-001-06- 60 TABLET in 1 BOTTLE (10702-001-06)

10702- KVK-TECH, INC.
- 10702-001- LOMAIRA
  - 10702-001-09- 90 TABLET in 1 BOTTLE (10702-001-09)

10702- KVK-TECH, INC.
- 10702-001- LOMAIRA
  - 10702-001-10- 1000 TABLET in 1 BOTTLE (10702-001-10)

10702- KVK-TECH, INC.
- 10702-001- LOMAIRA
  - 10702-001-25- 250 TABLET in 1 BOTTLE (10702-001-25)

10702- KVK-TECH, INC.
- 10702-001- LOMAIRA
  - 10702-001-50- 500 TABLET in 1 BOTTLE (10702-001-50)

10702- KVK-TECH, Inc.
- 10702-025- Phentermine Hydrochloride
  - 10702-025-01- 100 TABLET in 1 BOTTLE (10702-025-01)

10702- KVK-TECH, Inc.
- 10702-025- Phentermine Hydrochloride
  - 10702-025-03- 30 TABLET in 1 BOTTLE (10702-025-03)

10702- KVK-TECH, Inc.
- 10702-025- Phentermine Hydrochloride
  - 10702-025-10- 1000 TABLET in 1 BOTTLE (10702-025-10)

10702- KVK-Tech, Inc.
- 10702-026- Phentermine Hydrochloride
  - 10702-026-01- 100 CAPSULE in 1 BOTTLE (10702-026-01)

10702- KVK-Tech, Inc.
- 10702-026- Phentermine Hydrochloride
  - 10702-026-03- 30 CAPSULE in 1 BOTTLE (10702-026-03)

10702- KVK-Tech, Inc.
- 10702-026- Phentermine Hydrochloride
  - 10702-026-10- 1000 CAPSULE in 1 BOTTLE (10702-026-10)

10702- KVK-Tech, Inc.
- 10702-027- Phentermine Hydrochloride
  - 10702-027-01- 100 CAPSULE in 1 BOTTLE (10702-027-01)

10702- KVK-Tech, Inc.
- 10702-027- Phentermine Hydrochloride
  - 10702-027-03- 30 CAPSULE in 1 BOTTLE (10702-027-03)

10702- KVK-Tech, Inc.
- 10702-027- Phentermine Hydrochloride
  - 10702-027-10- 1000 CAPSULE in 1 BOTTLE (10702-027-10)

10702- KVK-Tech, Inc.
- 10702-028- Phentermine Hydrochloride
  - 10702-028-01- 100 CAPSULE in 1 BOTTLE (10702-028-01)

10702- KVK-Tech, Inc.
- 10702-028- Phentermine Hydrochloride
  - 10702-028-03- 30 CAPSULE in 1 BOTTLE (10702-028-03)

10702- KVK-Tech, Inc.
- 10702-028- Phentermine Hydrochloride
  - 10702-028-10- 1000 CAPSULE in 1 BOTTLE (10702-028-10)

10702- KVK-TECH, Inc.
- 10702-029- Phentermine Hydrochloride
  - 10702-029-01- 100 CAPSULE in 1 BOTTLE (10702-029-01)

10702- KVK-TECH, Inc.
- 10702-029- Phentermine Hydrochloride
  - 10702-029-03- 30 CAPSULE in 1 BOTTLE (10702-029-03)

10702- KVK-TECH, Inc.
- 10702-029- Phentermine Hydrochloride
  - 10702-029-10- 1000 CAPSULE in 1 BOTTLE (10702-029-10)

10702- KVK-TECH, Inc.
- 10702-067- Phentermine Hydrochloride
  - 10702-067-03- 30 TABLET in 1 BOTTLE (10702-067-03)

10702- KVK-TECH, Inc.
- 10702-067- Phentermine Hydrochloride
  - 10702-067-05- 5000 TABLET in 1 BOTTLE (10702-067-05)

10702- KVK-TECH, Inc.
- 10702-067- Phentermine Hydrochloride
  - 10702-067-10- 1000 TABLET in 1 BOTTLE (10702-067-10)

11534- SUNRISE PHARMACEUTICAL, INC.
- 11534-157- Phentermine Hydrochloride
  - 11534-157-01- 100 CAPSULE in 1 BOTTLE (11534-157-01)

11534- SUNRISE PHARMACEUTICAL, INC.
- 11534-157- Phentermine Hydrochloride
  - 11534-157-03- 1000 CAPSULE in 1 BOTTLE (11534-157-03)

11534- SUNRISE PHARMACEUTICAL, INC.
- 11534-159- Phentermine hydrochloride
  - 11534-159-01- 100 CAPSULE in 1 BOTTLE (11534-159-01)

11534- SUNRISE PHARMACEUTICAL, INC.
- 11534-159- Phentermine hydrochloride
  - 11534-159-03- 1000 CAPSULE in 1 BOTTLE (11534-159-03)

11534- SUNRISE PHARMACEUTICAL, INC.
- 11534-159- Phentermine hydrochloride
  - 11534-159-30- 30 CAPSULE in 1 BOTTLE (11534-159-30)

11534- SUNRISE PHARMACEUTICAL, INC.
- 11534-160- Phentermine hydrochloride
  - 11534-160-01- 100 TABLET in 1 BOTTLE (11534-160-01)

11534- SUNRISE PHARMACEUTICAL, INC.
- 11534-160- Phentermine hydrochloride
  - 11534-160-03- 1000 TABLET in 1 BOTTLE (11534-160-03)

11534- SUNRISE PHARMACEUTICAL, INC.
- 11534-160- Phentermine hydrochloride
  - 11534-160-30- 30 TABLET in 1 BOTTLE (11534-160-30)

11534- SUNRISE PHARMACEUTICAL, INC.
- 11534-176- Phentermine Hydrochloride
  - 11534-176-01- 100 CAPSULE in 1 BOTTLE (11534-176-01)

11534- SUNRISE PHARMACEUTICAL, INC.
- 11534-176- Phentermine Hydrochloride
  - 11534-176-03- 1000 CAPSULE in 1 BOTTLE (11534-176-03)

13107- Aurolife Pharma, LLC
- 13107-061- Phentermine Hydrochloride
  - 13107-061-01- 100 TABLET in 1 BOTTLE (13107-061-01)

13107- Aurolife Pharma, LLC
- 13107-061- Phentermine Hydrochloride
  - 13107-061-05- 500 TABLET in 1 BOTTLE (13107-061-05)

13107- Aurolife Pharma, LLC
- 13107-061- Phentermine Hydrochloride
  - 13107-061-30- 30 TABLET in 1 BOTTLE (13107-061-30)

13107- Aurolife Pharma, LLC
- 13107-061- Phentermine Hydrochloride
  - 13107-061-99- 1000 TABLET in 1 BOTTLE (13107-061-99)

13107- Aurolife Pharma, LLC
- 13107-105- Phentermine
  - 13107-105-01- 100 CAPSULE in 1 BOTTLE (13107-105-01)

13107- Aurolife Pharma, LLC
- 13107-105- Phentermine
  - 13107-105-30- 30 CAPSULE in 1 BOTTLE (13107-105-30)

13107- Aurolife Pharma, LLC
- 13107-106- Phentermine
  - 13107-106-01- 100 CAPSULE in 1 BOTTLE (13107-106-01)

13107- Aurolife Pharma, LLC
- 13107-106- Phentermine
  - 13107-106-30- 30 CAPSULE in 1 BOTTLE (13107-106-30)

17224- Calvin Scott & Co., Inc.
- 17224-840- LOMAIRA
  - 17224-840-28- 28 TABLET in 1 BOTTLE (17224-840-28)

17224- Calvin Scott & Co., Inc.
- 17224-840- LOMAIRA
  - 17224-840-60- 60 TABLET in 1 BOTTLE (17224-840-60)

17224- Calvin Scott & Co., Inc.
- 17224-840- LOMAIRA
  - 17224-840-90- 90 TABLET in 1 BOTTLE (17224-840-90)

17224- Calvin Scott & Co., Inc.
- 17224-851- Phentermine Hydrochloride
  - 17224-851-21- 21 CAPSULE in 1 BOTTLE (17224-851-21)

17224- Calvin Scott & Co., Inc.
- 17224-851- Phentermine Hydrochloride
  - 17224-851-28- 28 CAPSULE in 1 BOTTLE (17224-851-28)

17224- Calvin Scott & Co., Inc.
- 17224-851- Phentermine Hydrochloride
  - 17224-851-30- 30 CAPSULE in 1 BOTTLE (17224-851-30)

17224- Calvin Scott & Co., Inc.
- 17224-870- Phentermine Hydrochloride
  - 17224-870-21- 21 CAPSULE in 1 BOTTLE (17224-870-21)

17224- Calvin Scott & Co., Inc.
- 17224-870- Phentermine Hydrochloride
  - 17224-870-28- 28 CAPSULE in 1 BOTTLE (17224-870-28)

17224- Calvin Scott & Co., Inc.
- 17224-870- Phentermine Hydrochloride
  - 17224-870-30- 30 CAPSULE in 1 BOTTLE (17224-870-30)

17224- Calvin Scott & Co., Inc.
- 17224-870- Phentermine Hydrochloride
  - 17224-870-42- 42 CAPSULE in 1 BOTTLE (17224-870-42)

17224- Calvin Scott & Co., Inc.
- 17224-872- Phentermine Hydrochloride
  - 17224-872-21- 21 CAPSULE in 1 BOTTLE (17224-872-21)

17224- Calvin Scott & Co., Inc.
- 17224-872- Phentermine Hydrochloride
  - 17224-872-28- 28 CAPSULE in 1 BOTTLE (17224-872-28)

17224- Calvin Scott & Co., Inc.
- 17224-872- Phentermine Hydrochloride
  - 17224-872-42- 42 CAPSULE in 1 BOTTLE (17224-872-42)

17224- Calvin Scott & Co., Inc.
- 17224-877- Phentermine Hydrochloride
  - 17224-877-07- 7 CAPSULE in 1 BOTTLE (17224-877-07)

17224- Calvin Scott & Co., Inc.
- 17224-877- Phentermine Hydrochloride
  - 17224-877-14- 14 CAPSULE in 1 BOTTLE (17224-877-14)

17224- Calvin Scott & Co., Inc.
- 17224-877- Phentermine Hydrochloride
  - 17224-877-21- 21 CAPSULE in 1 BOTTLE (17224-877-21)

17224- Calvin Scott & Co., Inc.
- 17224-877- Phentermine Hydrochloride
  - 17224-877-28- 28 CAPSULE in 1 BOTTLE (17224-877-28)

17224- Calvin Scott & Co., Inc.
- 17224-877- Phentermine Hydrochloride
  - 17224-877-30- 30 CAPSULE in 1 BOTTLE (17224-877-30)

17224- Calvin Scott & Co., Inc.
- 17224-877- Phentermine Hydrochloride
  - 17224-877-60- 60 CAPSULE in 1 BOTTLE (17224-877-60)

17224- Calvin Scott & Co., Inc.
- 17224-890- Phentermine
  - 17224-890-14- 14 CAPSULE in 1 BOTTLE (17224-890-14)

17224- Calvin Scott & Co., Inc.
- 17224-890- Phentermine
  - 17224-890-21- 21 CAPSULE in 1 BOTTLE (17224-890-21)

17224- Calvin Scott & Co., Inc.
- 17224-890- Phentermine
  - 17224-890-28- 28 CAPSULE in 1 BOTTLE (17224-890-28)

17224- Calvin Scott & Co., Inc.
- 17224-890- Phentermine
  - 17224-890-30- 30 CAPSULE in 1 BOTTLE (17224-890-30)

17224- Calvin Scott & Co., Inc.
- 17224-890- Phentermine
  - 17224-890-56- 56 CAPSULE in 1 BOTTLE (17224-890-56)

17224- Calvin Scott & Co., Inc.
- 17224-901- Phentermine Hydrochloride
  - 17224-901-07- 7 TABLET in 1 BOTTLE, PLASTIC (17224-901-07)

17224- Calvin Scott & Co., Inc.
- 17224-901- Phentermine Hydrochloride
  - 17224-901-14- 14 TABLET in 1 BOTTLE, PLASTIC (17224-901-14)

17224- Calvin Scott & Co., Inc.
- 17224-901- Phentermine Hydrochloride
  - 17224-901-28- 28 TABLET in 1 BOTTLE, PLASTIC (17224-901-28)

17224- Calvin Scott & Co., Inc.
- 17224-901- Phentermine Hydrochloride
  - 17224-901-30- 30 TABLET in 1 BOTTLE, PLASTIC (17224-901-30)

17224- Calvin Scott & Co., Inc.
- 17224-901- Phentermine Hydrochloride
  - 17224-901-45- 45 TABLET in 1 BOTTLE, PLASTIC (17224-901-45)

17224- Calvin Scott & Co., Inc.
- 17224-901- Phentermine Hydrochloride
  - 17224-901-60- 60 TABLET in 1 BOTTLE, PLASTIC (17224-901-60)

17224- Calvin Scott & Co., Inc.
- 17224-901- Phentermine Hydrochloride
  - 17224-901-90- 90 TABLET in 1 BOTTLE, PLASTIC (17224-901-90)

17224- Calvin Scott & Co., Inc.
- 17224-902- Phentermine Hydrochloride
  - 17224-902-07- 7 TABLET in 1 BOTTLE, PLASTIC (17224-902-07)

17224- Calvin Scott & Co., Inc.
- 17224-902- Phentermine Hydrochloride
  - 17224-902-14- 14 TABLET in 1 BOTTLE, PLASTIC (17224-902-14)

17224- Calvin Scott & Co., Inc.
- 17224-902- Phentermine Hydrochloride
  - 17224-902-21- 21 TABLET in 1 BOTTLE, PLASTIC (17224-902-21)

17224- Calvin Scott & Co., Inc.
- 17224-902- Phentermine Hydrochloride
  - 17224-902-28- 28 TABLET in 1 BOTTLE, PLASTIC (17224-902-28)

17224- Calvin Scott & Co., Inc.
- 17224-902- Phentermine Hydrochloride
  - 17224-902-30- 30 TABLET in 1 BOTTLE, PLASTIC (17224-902-30)

17224- Calvin Scott & Co., Inc.
- 17224-902- Phentermine Hydrochloride
  - 17224-902-32- 32 TABLET in 1 BOTTLE, PLASTIC (17224-902-32)

17224- Calvin Scott & Co., Inc.
- 17224-902- Phentermine Hydrochloride
  - 17224-902-45- 45 TABLET in 1 BOTTLE, PLASTIC (17224-902-45)

17224- Calvin Scott & Co., Inc.
- 17224-902- Phentermine Hydrochloride
  - 17224-902-56- 56 TABLET in 1 BOTTLE, PLASTIC (17224-902-56)

17224- Calvin Scott & Co., Inc.
- 17224-902- Phentermine Hydrochloride
  - 17224-902-60- 60 TABLET in 1 BOTTLE, PLASTIC (17224-902-60)

17224- Calvin Scott & Co., Inc.
- 17224-904- Phentermine hydrochloride
  - 17224-904-07- 7 TABLET in 1 BOTTLE (17224-904-07)

17224- Calvin Scott & Co., Inc.
- 17224-904- Phentermine hydrochloride
  - 17224-904-28- 28 TABLET in 1 BOTTLE (17224-904-28)

17224- Calvin Scott & Co., Inc.
- 17224-904- Phentermine hydrochloride
  - 17224-904-30- 30 TABLET in 1 BOTTLE (17224-904-30)

17224- Calvin Scott & Co., Inc.
- 17224-904- Phentermine hydrochloride
  - 17224-904-60- 60 TABLET in 1 BOTTLE (17224-904-60)

17224- Calvin Scott & Co., Inc.
- 17224-905- Phentermine HCL
  - 17224-905-14- 14 TABLET in 1 BOTTLE (17224-905-14)

17224- Calvin Scott & Co., Inc.
- 17224-905- Phentermine HCL
  - 17224-905-28- 28 TABLET in 1 BOTTLE (17224-905-28)

17224- Calvin Scott & Co., Inc.
- 17224-905- Phentermine HCL
  - 17224-905-30- 30 TABLET in 1 BOTTLE (17224-905-30)

17224- Calvin Scott & Co., Inc.
- 17224-905- Phentermine HCL
  - 17224-905-56- 56 TABLET in 1 BOTTLE (17224-905-56)

17224- Calvin Scott & Co., Inc.
- 17224-905- Phentermine HCL
  - 17224-905-60- 60 TABLET in 1 BOTTLE (17224-905-60)

17224- Calvin Scott & Co., Inc.
- 17224-905- Phentermine HCL
  - 17224-905-84- 84 TABLET in 1 BOTTLE (17224-905-84)

17224- Calvin Scott & Co., Inc.
- 17224-907- Phentermine Hydrochloride
  - 17224-907-07- 7 TABLET in 1 BOTTLE (17224-907-07)

17224- Calvin Scott & Co., Inc.
- 17224-907- Phentermine Hydrochloride
  - 17224-907-14- 14 TABLET in 1 BOTTLE (17224-907-14)

17224- Calvin Scott & Co., Inc.
- 17224-907- Phentermine Hydrochloride
  - 17224-907-28- 28 TABLET in 1 BOTTLE (17224-907-28)

17224- Calvin Scott & Co., Inc.
- 17224-907- Phentermine Hydrochloride
  - 17224-907-30- 30 TABLET in 1 BOTTLE (17224-907-30)

17224- Calvin Scott & Co., Inc.
- 17224-907- Phentermine Hydrochloride
  - 17224-907-42- 42 TABLET in 1 BOTTLE (17224-907-42)

17224- Calvin Scott & Co., Inc.
- 17224-907- Phentermine Hydrochloride
  - 17224-907-45- 45 TABLET in 1 BOTTLE (17224-907-45)

17224- Calvin Scott & Co., Inc.
- 17224-907- Phentermine Hydrochloride
  - 17224-907-56- 56 TABLET in 1 BOTTLE (17224-907-56)

section name header

Pronunciation ⬇

Classifications ⬆ ⬇

Indications ⬆ ⬇

Action ⬆ ⬇

Pharmacokinetics ⬆ ⬇

Time/Action Profile ⬆ ⬇

Contraind./Precautions ⬆ ⬇

Adv. Reactions/Side Effects ⬆ ⬇

Interactions ⬆ ⬇

Route/Dosage ⬆ ⬇

Availability ⬆ ⬇

Assessment ⬆ ⬇

Implementation ⬆ ⬇

Patient/Family Teaching ⬆ ⬇

Evaluation/Desired Outcomes ⬆ ⬇

US Brand Names ⬆ ⬇

Contr. Subst. Schedule ⬆ ⬇

Code ⬆