section name header

Pronunciation ⬇

ER-goe-kal-SIF-e-role

Classifications ⬆ ⬇

Therapeutic Classification: vitamins

Pharmacologic Classification: fat soluble vitamins

Indications ⬆ ⬇

REMS

Action ⬆ ⬇

  • Requires activation in the liver and kidneys to create the active form of vitamin D2.
  • Promotes the absorption of calcium and decreases parathyroid hormone concentrations.
Therapeutic effects:
  • Treatment and prevention of deficiency states, particularly bone manifestations.
  • Improved calcium and phosphorous homeostasis.

Pharmacokinetics ⬆ ⬇

Absorption: Well absorbed.

Distribution: Unknown.

Metabolism/Excretion: Converted to the active form of vitamin D2 by sunlight, the liver, and the kidneys.

Half-Life: Unknown.

Time/Action Profile ⬆ ⬇

(effects on serum calcium)

ROUTEONSETPEAKDURATION
PO12–24 hr4 wkunknown

Contraind./Precautions ⬆ ⬇

Contraindicated in:

Use Cautiously in:

Adv. Reactions/Side Effects ⬆ ⬇

Seen primarily as manifestations of toxicity (hypercalcemia)

CV: arrhythmias, edema, hypertension

Derm: pruritus

EENT: conjunctivitis, photophobia, rhinorrhea

F and E: hypercalcemia

GI: ↑liver enzymes, anorexia, constipation, dry mouth, metallic taste, nausea, PANCREATITIS, polydipsia, vomiting, weight loss

GU: ↓libido, albuminuria, azotemia, nocturia, polyuria

Metab: hyperthermia

MS: bone pain, metastatic calcification, muscle pain

Neuro: dizziness, headache, malaise, somnolence, weakness

Resp: dyspnea

Interactions ⬆ ⬇

Drug-drug:

Drug-Food:

Route/Dosage ⬆ ⬇

Familial Hypophosphatemia

Hypoparathyroidism

Vitamin D-Resistant Rickets

Adequate Intake

Availability ⬆ ⬇

(Generic available)

Assessment ⬆ ⬇

Lab Test Considerations:

Toxicity and Overdose:

Implementation ⬆ ⬇

Patient/Family Teaching ⬆ ⬇

Evaluation/Desired Outcomes ⬆ ⬇

US Brand Names ⬆ ⬇

Drisdol, vitamin D2

Code ⬆

NDC Code