a-PIX-a-ban
High Alert
Absorption: 50% absorbed following oral administration.
Distribution: Unknown.
Half-Life: 6 hr (12 hr after repeated dosing due to prolonged absorption).
Contraindicated in:
Use Cautiously in:
Neuroaxial spinal anesthesia or spinal puncture, especially if concurrent with an indwelling epidural catheter; drugs affecting hemostasis; or history of traumatic/repeated spinal puncture or spinal deformity (↑ risk of epidural or spinal hematoma)
;Drug-drug:
Drug-Natural Products:
Reduction in Risk of Stroke/Systemic Embolism in Nonvalvular Atrial Fibrillation
Renal Impairment
Prevention of Deep Vein Thrombosis Following Knee or Hip Replacement Surgery
Treatment of Deep Vein Thrombosis or Pulmonary Embolism
Reduction in Risk of Recurrence of Deep Vein Thrombosis or Pulmonary Embolism
Toxicity and Overdose:
If apixaban is discontinued for a reason other than bleeding or completion of a course of therapy, consider coverage with another anticoagulant because of ↑ risk of thromboembolism when apixaban is prematurely discontinued.
Explain purpose and side effects of medication. Advise patient to read Patient Information before starting therapy and to take missed dose as soon as remembered on the same day; then resume twice daily; do not double doses. Do not discontinue without consulting health care provider.
Inform patient having had neuraxial anesthesia or spinal puncture to watch for signs and symptoms of spinal or epidural hematoma (numbness or weakness of legs, bowel or bladder dysfunction). Notify health care provider immediately if symptoms occur.
NDC Code