carboprost

KAR-bo-prost

Therapeutic Classification: abortifacients

Pharmacologic Classification: oxytocics, prostaglandins

REMS

Induction of midtrimester abortion.
Postpartum hemorrhage that has not responded to conventional therapy.

Causes uterine contractions by directly stimulating the myometrium.

Therapeutic effects:

Expulsion of fetus.
Control of postpartum bleeding.

Absorption: Well absorbed following IM administration.

Distribution: Unknown.

Metabolism/Excretion: Unknown.

Half-Life: Unknown.

(peak noted as mean abortion time)

ROUTE	ONSET	PEAK	DURATION
IM	unknown	16 hr	unknown

Contraindicated in:

Hypersensitivity;
Acute pelvic inflammatory disease;
Active pulmonary, renal, or hepatic disease.

Use Cautiously in:

Uterine scarring;
Asthma;
Hypotension;
Hypertension;
Cardiac disease;
Adrenal disease;
Anemia;
Jaundice;
Diabetes mellitus;
Seizure disorders.

Derm: flushing

GI: diarrhea, nausea, vomiting, abdominal pain, cramps

GU: UTERINE RUPTURE

Neuro: dizziness, headache

Resp: wheezing

Misc: fever, chills, HYPERSENSITIVITY REACTIONS (INCLUDING ANAPHYLAXIS AND ANGIOEDEMA), shivering

Drug-drug:

Augments the effects of other oxytocic agents.

Test Dose

IM (Adults ): 100 mcg.

Abortifacient

IM (Adults ): 250 mcg every 1.5–3.5 hr depending upon uterine response; may be ↑ to 500 mcg if several doses of 250 mcg produce inadequate response (not to exceed 2 days of continuous therapy or total dose of 12 mg).

Refractory Postpartum Uterine Bleeding

IM (Adults ): 250 mcg; may be repeated every 15–90 min (total dose not to exceed 2 mg).

(Generic available)

Solution for injection: 250 mcg/mL

Monitor frequency, duration, and force of contractions and uterine resting tone. Notify health care provider if contractions are absent or last >1 min.
Monitor temperature, BP, and HR periodically throughout course of therapy. Large dose may cause hypertension. Temperature elevation beginning 1–16 hr after initiation of therapy and lasting for several hours is not unusual.
Monitor for signs and symptoms of anaphylaxis (wheezing; chest tightness; dyspnea; rash; pruritus; swelling of face, lips, or throat). Provide supportive care if symptoms occur.
Assess for nausea, vomiting, and diarrhea. Vomiting and diarrhea occur in approximately two-thirds of patients. Premedication with antiemetic and antidiarrheal is recommended.
Monitor amount and type of vaginal discharge. Notify health care provider immediately if symptoms of hemorrhage (increased bleeding, hypotension, pallor, tachycardia) occur.

Carboprost should be used only with strict adherence to recommended dosages. It should be used by medically trained personnel in a hospital that can provide immediate intensive care and acute surgical facilities.
Avoid contact with skin. Thoroughly wash skin immediately after spillage.
- Opioid analgesic may be given for uterine cramping.
- Store in refrigerator.
IM: Administer deep IM. Dose may be repeated every 1.5–3.5 hr. Rotate sites.

Explain purpose of vaginal examinations (to assess for trauma to cervix).
- Instruct patient to notify health care provider immediately if fever and chills, foul-smelling vaginal discharge, lower abdominal pain, or increased bleeding occurs.

Complete abortion.
Control of postpartum or postabortal hemorrhage.

Hemabate

NDC Code

0009- Pharmacia & Upjohn Company LLC
- 0009-0856- Hemabate
  - 0009-0856-05- 1 mL in 1 AMPULE (0009-0856-05)

0009- Pharmacia & Upjohn Company LLC
- 0009-0856- Hemabate
  - 0009-0856-08- 10 AMPULE in 1 PACKAGE (0009-0856-08) / 1 mL in 1 AMPULE (0009-0856-05)

0409- Hospira, Inc.
- 0409-0064- carboprost tromethamine
  - 0409-0064-10- 10 VIAL in 1 CARTON (0409-0064-10) / 1 mL in 1 VIAL

42571- Micro Labs Limited
- 42571-435- Carboprost Tromethamine
  - 42571-435-72- 10 VIAL in 1 CARTON (42571-435-72) / 1 mL in 1 VIAL (42571-435-54)

43598- Dr. Reddy's Laboratories Inc.
- 43598-179- Carboprost Tromethamine
  - 43598-179-10- 10 SYRINGE in 1 CARTON (43598-179-10) / 1 mL in 1 SYRINGE (43598-179-11)

43598- Dr. Reddy's Laboratories Inc.
- 43598-698- Carboprost Tromethamine
  - 43598-698-11- 1 VIAL, SINGLE-DOSE in 1 CARTON (43598-698-11) / 1 mL in 1 VIAL, SINGLE-DOSE

43598- Dr. Reddy's Laboratories Inc.
- 43598-698- Carboprost Tromethamine
  - 43598-698-58- 10 VIAL, SINGLE-DOSE in 1 CARTON (43598-698-58) / 1 mL in 1 VIAL, SINGLE-DOSE

43598- Dr. Reddys Laboratories Inc.
- 43598-917- CARBOPROST TROMETHAMINE
  - 43598-917-58- 10 VIAL, SINGLE-DOSE in 1 CARTON (43598-917-58) / 1 mL in 1 VIAL, SINGLE-DOSE (43598-917-11)

43598- Dr. Reddys Laboratories Inc.
- 43598-919- CARBOPROST TROMETHAMINE
  - 43598-919-58- 10 VIAL, SINGLE-DOSE in 1 CARTON (43598-919-58) / 1 mL in 1 VIAL, SINGLE-DOSE (43598-919-11)

46708- Alembic Pharmaceuticals Limited
- 46708-777- CARBOPROST TROMETHAMINE
  - 46708-777-10- 10 VIAL in 1 CARTON (46708-777-10) / 1 mL in 1 VIAL (46708-777-01)

54893- MSN Laboratories Private Limited
- 54893-0023-
  - 54893-0023-6- 3 kg in 1 DRUM (54893-0023-6)

55150- Eugia US LLC
- 55150-459- CARBOPROST TROMETHAMINE
  - 55150-459-10- 10 VIAL, SINGLE-DOSE in 1 CARTON (55150-459-10) / 1 mL in 1 VIAL, SINGLE-DOSE (55150-459-01)

62227- BrightGene Bio-Medical Technology Co., Ltd.
- 62227-023-
  - 62227-023-01- 74 g in 1 BAG (62227-023-01)

62332- Alembic Pharmaceuticals Inc.
- 62332-777- CARBOPROST TROMETHAMINE
  - 62332-777-10- 10 VIAL in 1 CARTON (62332-777-10) / 1 mL in 1 VIAL (62332-777-01)

62559- ANI Pharmaceuticals, Inc.
- 62559-900- Carboprost Tromethamine
  - 62559-900-01- 10 VIAL, SINGLE-DOSE in 1 CARTON (62559-900-01) / 1 mL in 1 VIAL, SINGLE-DOSE (62559-900-11)

65145- Caplin Steriles Limited
- 65145-132- CARBOPROST TROMETHAMINE
  - 65145-132-10- 10 VIAL in 1 CARTON (65145-132-10) / 1 mL in 1 VIAL (65145-132-01)

65219- Fresenius Kabi USA, LLC
- 65219-579- CARBOPROST TROMETHAMINE
  - 65219-579-01- 10 VIAL in 1 CARTON (65219-579-01) / 1 mL in 1 VIAL (65219-579-00)

68083- Gland Pharma Limited
- 68083-584- carboprost tromethamine
  - 68083-584-10- 10 VIAL in 1 CARTON (68083-584-10) / 1 mL in 1 VIAL

68245- Chirogate International Inc.
- 68245-0016-
  - 68245-0016-1- 1 g in 1 BAG (68245-0016-1)

68245- Chirogate International Inc.
- 68245-0016-
  68245-0016-2- 10 g in 1 BAG (68245-0016-2)

68245- Chirogate International Inc.
- 68245-0016-
  68245-0016-3- 20 g in 1 BAG (68245-0016-3)

68245- Chirogate International Inc.
- 68245-0016-
  68245-0016-4- 50 g in 1 BAG (68245-0016-4)

68245- Chirogate International Inc.
- 68245-0016-
  68245-0016-5- 100 g in 1 BAG (68245-0016-5)

70121- Amneal Pharmaceuticals LLC
- 70121-1680- carboprost tromethamine
  70121-1680-7- 10 VIAL in 1 CARTON (70121-1680-7) / 1 mL in 1 VIAL (70121-1680-1)

70512- SOLA Pharmaceuticals, LLC
- 70512-859- carboprost tromethamine
  - 70512-859-05- 5 VIAL, SINGLE-DOSE in 1 CARTON (70512-859-05) / 1 mL in 1 VIAL, SINGLE-DOSE (70512-859-01)

70594- Xellia Pharmaceuticals USA LLC
- 70594-112- Carboprost Tromethamine
  - 70594-112-02- 10 VIAL in 1 CARTON (70594-112-02) / 1 mL in 1 VIAL (70594-112-01)

71839- BE Pharmaceuticals Inc.
- 71839-137- CARBOPROST TROMETHAMINE
  - 71839-137-10- 10 VIAL in 1 CARTON (71839-137-10) / 1 mL in 1 VIAL (71839-137-01)

81298- Long Grove Pharmaceuticals, LLC
- 81298-5010- Carboprost Tromethamine
  - 81298-5010-3- 10 CARTON in 1 BOX (81298-5010-3) / 1 VIAL, SINGLE-DOSE in 1 CARTON (81298-5010-1) / 1 mL in 1 VIAL, SINGLE-DOSE

81298- Long Grove Pharmaceuticals, LLC
- 81298-5010- Carboprost Tromethamine
  - 81298-5010-5- 1 CARTON in 1 BOX (81298-5010-5) / 1 VIAL, SINGLE-DOSE in 1 CARTON (81298-5010-1) / 1 mL in 1 VIAL, SINGLE-DOSE

81665- Omnivium Pharmaceuticals LLC
- 81665-202- CARBOPROST TROMETHAMINE
  - 81665-202-01- 1 mL in 1 AMPULE (81665-202-01)

81665- Omnivium Pharmaceuticals LLC
- 81665-202- CARBOPROST TROMETHAMINE
  - 81665-202-10- 10 AMPULE in 1 CARTON (81665-202-10) / 1 mL in 1 AMPULE (81665-202-01)

82231- EUROAPI Hungary Ltd.
- 82231-103-
  - 82231-103-01- 10 g in 1 BOTTLE (82231-103-01)

83270- ONESOURCE SPECIALTY PHARMA LIMITED
- 83270-002- Carboprost Tromethamine
  83270-002-02- 10 VIAL in 1 CARTON (83270-002-02) / 1 mL in 1 VIAL (83270-002-01)

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Pronunciation ⬇

Classifications ⬆ ⬇

Indications ⬆ ⬇

Action ⬆ ⬇

Pharmacokinetics ⬆ ⬇

Time/Action Profile ⬆ ⬇

Contraind./Precautions ⬆ ⬇

Adv. Reactions/Side Effects ⬆ ⬇

Interactions ⬆ ⬇

Route/Dosage ⬆ ⬇

Availability ⬆ ⬇

Assessment ⬆ ⬇

Implementation ⬆ ⬇

Patient/Family Teaching ⬆ ⬇

Evaluation/Desired Outcomes ⬆ ⬇

US Brand Names ⬆ ⬇

Code ⬆