a-seet-a-MIN-oh-fen
REMS
Absorption: Well absorbed following oral administration. Rectal absorption is variable. Intravenous administration results in complete bioavailability.
Distribution: Widely distributed. Crosses the placenta; enters breast milk in low concentrations.
Half-Life: Neonates: 7 hr; Infants and Children: 3–4 hr; Adults: 1–3 hr.
(analgesia and antipyresis)
| ROUTE | ONSET | PEAK | DURATION |
|---|---|---|---|
| PO | 0.5–1 hr | 1–3 hr | 3–8 hr‡ |
| Rect | 0.5–1 hr | 1–3 hr | 3–4 hr |
| IV‡ | within 30 min | 30 min | 4–6 hr |
‡Depends on dose.
‡Antipyretic effects.
Contraindicated in:
Use Cautiously in:
CV: hypertension (IV), hypotension (IV)
Derm: ACUTE GENERALIZED EXANTHEMATOUS PUSTULOSIS, rash, STEVENS-JOHNSON SYNDROME (SJS), TOXIC EPIDERMAL NECROLYSIS, urticaria
F and E: hypokalemia (IV)
GI: ↑liver enzymes, constipation (↑ in children) (IV), HEPATOTOXICITY (WITH HIGHER DOSES), nausea (IV), vomiting (IV)
GU: renal failure (high doses/chronic use)
Hemat: neutropenia, pancytopenia
MS: muscle spasms (IV), trismus (IV)
Neuro: agitation (↑ in children) (IV), anxiety (IV), fatigue (IV), headache (IV), insomnia (IV)
Resp: atelectasis (↑ in children) (IV), dyspnea (IV)
Drug-drug:
Assess amount, frequency, and type of drugs taken in patients self-medicating, especially with OTC drugs. Prolonged use of acetaminophen ↑ risk of adverse hepatic and renal effects. Do not exceed maximum daily dose of acetaminophen when considering all routes of administration and all combination products containing acetaminophen.
Lab Test Considerations:
Toxicity and Overdose:
To prevent fatal medication errors with IV dosing, ensure dose in milligrams (mg) and milliliters (mL) is not confused, dosing is based on weight for patients under 50 kg, infusion pump is programmed for accuracy, and total daily dose of acetaminophen from all sources does not exceed maximum daily limits.
IV Administration:
NDC Code