cyclophosphamide

sye-kloe-FOS-fa-mide

Therapeutic Classification: antineoplastics, Immunosuppressant agents

Pharmacologic Classification: alkylating agents

High Alert

Alone or with other modalities in the management of:
- Hodgkin disease,
- malignant lymphomas,
- multiple myeloma,
- leukemias,
- mycosis fungoides,
- neuroblastoma,
- ovarian carcinoma,
- breast carcinoma, and a variety of other tumors.
Minimal change nephrotic syndrome in children.

Unlabeled Use:

Severe active rheumatoid arthritis or granulomatosis with polyangiitis.

Interferes with DNA replication and RNA transcription, ultimately disrupting protein synthesis (cell-cycle phase-nonspecific).

Therapeutic effects:

Death of rapidly replicating cells, particularly malignant ones.
Also has immunosuppressant action in smaller doses.

Absorption: Inactive parent drug is well absorbed from the GI tract. IV administration results in complete bioavailability.

Distribution: Widely distributed. Limited penetration of the blood-brain barrier.

Metabolism/Excretion: Converted to active drug by the liver; 30% eliminated unchanged by the kidneys.

Half-Life: 4–6.5 hr.

(effects on blood counts)

ROUTE	ONSET	PEAK	DURATION
PO, IV	7 days	7–15 days	21 days

Contraindicated in:

Hypersensitivity;
OB: Pregnancy;
Lactation: Lactation.

Use Cautiously in:

Active infections;
Bone marrow depression;
Other chronic debilitating illnesses;
Rep: Women of reproductive potential.

CV: hypotension, MYOCARDIAL FIBROSIS

Derm: alopecia

Endo: gonadal suppression, syndrome of inappropriate antidiuretic hormone (SIADH)

GI: anorexia, nausea, vomiting

GU: hematuria, ↓fertility, HEMORRHAGIC CYSTITIS

Hemat: thrombocytopenia, anemia, LEUKOPENIA

Metab: hyperuricemia

Resp: PULMONARY FIBROSIS

Misc: SECONDARY MALIGNANCY

Drug-drug:

Phenobarbital or rifampin may ↑ toxicity of cyclophosphamide.
Concurrent allopurinol or thiazide diuretics may exaggerate bone marrow depression.
May prolong neuromuscular blockade from succinylcholine.
Cardiotoxicity may be additive with other cardiotoxic agents (e.g., cytarabine, daunorubicin, doxorubicin).
May ↓ digoxin levels and effectiveness.
Additive bone marrow depression with other antineoplastics or radiation therapy.
May potentiate the effects of warfarin.
May ↓ antibody response to live-virus vaccines and ↑ risk of adverse reactions.
Prolongs the effects of cocaine.

PO (Adults ): Induction and maintenance: 1–5 mg/kg/day.
PO (Children ): Induction: 2–8 mg/kg/day (60–250 mg/m²/day) in divided doses for 6 days or longer. Maintenance: 2–5 mg/kg (50–150 mg/m²/day) twice weekly.
IV (Adults ): 40–50 mg/kg in divided doses over 2–5 days or 10–15 mg/kg every 7–10 days or 3–5 mg/kg twice weekly or 1.5–3 mg/kg/day. Other regimens may use larger doses.
IV (Children ): Induction: 2–8 mg/kg/day (60–250 mg/m²/day) in divided doses for 6 days or longer. Total dose for 7 days may be given as a single weekly dose. Maintenance: 10–15 mg/kg every 7–10 days or 30 mg/kg every 3–4 wk.

(Generic available)

Capsules: 25 mg; 50 mg
Tablets: 25 mg; 50 mg
Lyophilized powder for injection: 200 mg/vial; 500 mg/vial; 1 g/vial; 2 g/vial
Solution for injection: 100 mg/mL; 200 mg/mL; 500 mg/mL

Monitor vital signs frequently during administration. Report significant changes.
Monitor urinary output frequently during therapy. To ↓ the risk of hemorrhagic cystitis and to promote excretion of uric acid, fluid intake should be ≥3000 mL/day for adults and ≥1000–2000 mL/day for children. May be administered with mesna. Alkalinization of the urine may be used to help prevent uric acid nephropathy.
Monitor for bone marrow depression. Assess for bleeding (bleeding gums; bruising; petechiae; guaiac stools, urine, and emesis) and avoid IM injections and taking rectal temperatures if platelet count is low. Apply pressure to venipuncture sites for 10 min. Assess for signs of infection during neutropenia. Anemia may occur. Monitor for ↑ fatigue, dyspnea, and orthostatic hypotension.
Assess nausea, vomiting, and appetite. Weigh weekly. Antiemetics may be given 30 min before administration of medication to minimize GI effects. Anorexia and weight loss can be minimized by feeding frequent light meals.
Assess cardiac and respiratory status for dyspnea, rales/crackles, cough, weight gain, or edema. Pulmonary toxicity may occur after prolonged therapy. Cardiotoxicity may occur early in therapy and is characterized by symptoms of HF.

Lab Test Considerations:

Monitor CBC with differential before and periodically during therapy. The nadir of leukopenia occurs in 7–12 days (recovery in 17–21 days). Leukocytes should be maintained at 2500–4000/mm³. May also cause thrombocytopenia (nadir 10–15 days) and rarely causes anemia.
- Monitor BUN, serum creatinine, and uric acid before and frequently during therapy to detect nephrotoxicity.
- Monitor ALT, AST, LDH, and serum bilirubin before and frequently during therapy to detect hepatotoxicity.
- Urinalysis should be evaluated before initiating therapy and frequently during therapy to detect hematuria or change in specific gravity indicative of SIADH.
- May suppress positive reactions to skin tests for Candida, mumps, Trichophyton, and tuberculin purified-protein derivative. May also produce false-positive results in Papanicolaou smears.

High Alert: Fatalities have occurred with chemotherapeutic agents. Before administering, clarify all ambiguous orders; double-check single, daily, and course-of-therapy dose limits; have second practitioner independently double-check original order, calculations, and infusion pump settings.
Do not confuse cyclophosphamide with cyclosporine or cycloserine.
Administer antiemetics before dosing with cyclophosphamide.
PO: Administer in the morning. DNC: Swallow tablets whole; do not crush, break, or chew.

IV Administration:

Provide adequate fluids (PO or IV) during or immediately after IV administration to force diuresis and ↓ risk of urinary tract toxicity.
IV: Wear gloves, gown, and mask while handling medication. If powder or solution comes in contact with skin or mucosa, wash thoroughly with soap and water. Discard equipment in specially designated containers.
Cyclophosphamide is an irritant. If extravasation occurs, immediately stop infusion. Leave needle/cannula in place temporarily but do not flush the line. Gently aspirate extravasated solution; then remove needle/cannula. Elevate patient's extremity.
IV Push: Reconstitution: Reconstitute each vial of lyophilized powder for injection with 25 mL (500 mg vial), 50 mL (1000 mg vial), or 100 mL (2000 mg vial) of 0.9% NaCl. Do not reconstitute with sterile water for injection; results in a hypotonic solution not suitable for IV push. Solution is clear, colorless to slight yellow; do not administer solutions that are cloudy, discolored, or contain particulate matter. Reconstituted solution can be stored at room temperature for up to 24 hr or in the refrigerator for up to 6 days. Concentration: 20 mg/mL.
Rate: Inject very slowly.
Intermittent Infusion: Reconstitution: Reconstitute each vial of lyophilized powder for injection with 25 mL (500 mg vial), 50 mL (1000 mg vial), or 100 mL (2000 mg vial) of 0.9% NaCl. Reconstituted solution can be stored at room temperature for up to 24 hr or in the refrigerator for up to 6 days. Concentration: 20 mg/mL. Diluent: Withdraw prescribed dose from vial and dilute with D5/0.9% NaCl, 0.45% NaCl, or D5W. Swirl gently to dissolve. Solutions diluted with 0.45% NaCl may be stored at room temperature for 24 hr or if refrigerated for 6 days. Solutions diluted with D5W or D5/0.9% NaCl are stable up to 24 hr at room temperature or 36 hr if refrigerated. Concentration: 2 mg/mL.
Y-Site Compatibility:
- acyclovir
- alemtuzumab
- allopurinol
- amikacin
- aminocaproic acid
- aminophylline
- amiodarone
- amphotericin B liposomal
- ampicillin/sulbactam
- anidulafungin
- argatroban
- arsenic trioxide
- atracurium
- atropine
- azithromycin
- aztreonam
- bivalirudin
- bleomycin
- bumetanide
- buprenorphine
- butorphanol
- calcium chloride
- calcium gluconate
- carboplatin
- carmustine
- caspofungin
- cefazolin
- cefepime
- cefotaxime
- cefotetan
- cefoxitin
- ceftazidime
- ceftriaxone
- cefuroxime
- chloramphenicol
- chlorpromazine
- chlorothiazide
- ciprofloxacin
- cisatracurium
- cisplatin
- cladribine
- clindamycin
- cyclosporine
- cytarabine
- dacarbazine
- dactinomycin
- daptomycin
- daunorubicin
- dexamethasone
- dexmedetomidine
- dexrazoxane
- digoxin
- diltiazem
- diphenhydramine
- dobutamine
- docetaxel
- dopamine
- doxorubicin hydrochloride
- doxorubicin liposomal
- doxycycline
- droperidol
- enalaprilat
- ephedrine
- epinephrine
- epirubicin
- ertapenem
- erythromycin
- esmolol
- etoposide
- etoposide phosphate
- famotidine
- fentanyl
- filgrastim
- fluconazole
- fludarabine
- fluorouracil
- foscarnet
- fosphenytoin
- furosemide
- ganciclovir
- gemcitabine
- gentamicin
- granisetron
- haloperidol
- heparin
- hetastarch
- hydralazine
- hydrocortisone
- hydromorphone
- idarubicin
- imipenem/cilastatin
- insulin, regular
- irinotecan
- isoproterenol
- ketorolac
- labetalol
- leucovorin
- levofloxacin
- lidocaine
- linezolid
- lorazepam
- magnesium sulfate
- mannitol
- melphalan
- meperidine
- meropenem
- mesna
- methadone
- methotrexate
- methylprednisolone
- metoclopramide
- metoprolol
- metronidazole
- midazolam
- milrinone
- minocycline
- mitomycin
- mitoxantrone
- morphine
- moxifloxacin
- nafcillin
- nalbuphine
- naloxone
- nicardipine
- nitroglycerin
- nitroprusside
- norepinephrine
- octreotide
- ondansetron
- oxacillin
- oxaliplatin
- oxytocin
- paclitaxel
- palonosetron
- pamidronate
- pantoprazole
- pemetrexed
- penicillin G
- pentamidine
- pentobarbital
- phenobarbital
- phentolamine
- phenylephrine
- piperacillin/tazobactam
- potassium acetate
- potassium chloride
- potassium phosphates
- procainamide
- prochlorperazine
- promethazine
- propofol
- propranolol
- remifentanil
- rituximab
- rocuronium
- sargramostim
- sodium acetate
- sodium bicarbonate
- sodium phosphates
- succinylcholine
- sufentanil
- tacrolimus
- theophylline
- thiotepa
- tigecycline
- tirofiban
- tobramycin
- topotecan
- trastuzumab
- trimethoprim/sulfamethoxazole
- vancomycin
- vasopressin
- vecuronium
- verapamil
- vinblastine
- vincristine
- vinorelbine
- voriconazole
- zidovudine
- zoledronic acid
Y-Site Incompatibility:
- amphotericin B deoxycholate
- diazepam
- gemtuzumab ozogamicin
- phenytoin

Instruct patient to take dose in early morning. Emphasize need for adequate fluid intake for 72 hr after therapy. Patient should void frequently to ↓ bladder irritation from metabolites excreted by the kidneys. Report hematuria immediately. If a dose is missed, contact health care provider. Advise caregivers to use gloves when handling capsules. If capsule opens, wash hands thoroughly.
Instruct patient to notify health care provider promptly if fever; sore throat; signs of infection; lower back or side pain; difficult or painful urination; sores in the mouth or on the lips; yellow discoloration of skin or eyes; bleeding gums; bruising; petechiae; blood in urine, stool, or emesis; unusual swelling of ankles or legs; joint pain; shortness of breath; cough; palpitations; weight gain >5 lb in 24 hr; dizziness; loss of consciousness; or confusion occurs. Caution patient to avoid crowds and persons with known infections. Instruct patient to use soft toothbrush and electric razor and to avoid falls. Patient should also be cautioned not to drink alcoholic beverages or to take products containing aspirin or NSAIDs; may precipitate GI hemorrhage.
Discuss with patient the possibility of hair loss. Explore methods of coping. May also cause darkening of skin and fingernails.
Instruct patient not to receive any vaccinations without advice of health care provider.
Rep: May cause fetal harm. Advise women of reproductive potential to use highly effective contraceptive measures for up to 1 yr after last dose and to avoid breastfeeding during and for 1–6 wk after last dose. Advise men with female partners of reproductive potential to wear condoms during and for ≥4 mo after last dose of therapy. Advise patient or notify health care provider if pregnancy is planned or suspected. Patients treated for rheumatic and musculoskeletal diseases should consider discontinuing cyclophosphamide 3–6 mo prior to conception to allow for disease monitoring and potential change to another immunosuppressant. Discontinue cyclophosphamide 12 wk before attempting conception in patients with rheumatic and musculoskeletal diseases who are planning to father a child. Inform patient that this medication may cause sterility and menstrual irregularities or cessation of menses.

Decrease in size or spread of malignant tumors.
Improvement of hematologic status in patients with leukemia. Maintenance therapy is instituted if leukocyte count remains between 2500 and 4000/mm³ and if patient does not demonstrate serious side effects.
Management of minimal change nephrotic syndrome in children.

NDC Code

0054- Hikma Pharmaceuticals USA Inc.
- 0054-0382- Cyclophosphamide
  - 0054-0382-25- 100 CAPSULE in 1 BOTTLE (0054-0382-25)

0054- Hikma Pharmaceuticals USA Inc.
- 0054-0383- Cyclophosphamide
  - 0054-0383-25- 100 CAPSULE in 1 BOTTLE (0054-0383-25)

0781- Sandoz Inc.
- 0781-3233- Cyclophosphamide
  - 0781-3233-94- 1 VIAL, SINGLE-DOSE in 1 CARTON (0781-3233-94) / 25 mL in 1 VIAL, SINGLE-DOSE

0781- Sandoz Inc.
- 0781-3244- Cyclophosphamide
  - 0781-3244-94- 1 VIAL, SINGLE-DOSE in 1 CARTON (0781-3244-94) / 50 mL in 1 VIAL, SINGLE-DOSE

0781- Sandoz Inc.
- 0781-3255- Cyclophosphamide
  - 0781-3255-94- 1 VIAL, SINGLE-DOSE in 1 CARTON (0781-3255-94) / 100 mL in 1 VIAL, SINGLE-DOSE

0781- Sandoz Inc
- 0781-3528- Cyclophosphamide
  - 0781-3528-10- 1 VIAL, MULTI-DOSE in 1 CARTON (0781-3528-10) / 5 mL in 1 VIAL, MULTI-DOSE (0781-3528-75)

0781- Sandoz Inc
- 0781-3529- Cyclophosphamide
  - 0781-3529-10- 1 VIAL, MULTI-DOSE in 1 CARTON (0781-3529-10) / 10 mL in 1 VIAL, MULTI-DOSE (0781-3529-70)

0781- Sandoz Inc
- 0781-3530- Cyclophosphamide
  - 0781-3530-10- 1 VIAL, MULTI-DOSE in 1 CARTON (0781-3530-10) / 20 mL in 1 VIAL, MULTI-DOSE (0781-3530-80)

10019- Baxter Healthcare Corporation
- 10019-935- CYCLOPHOSPHAMIDE
  - 10019-935-01- 1 VIAL, SINGLE-DOSE in 1 CARTON (10019-935-01) / 25 mL in 1 VIAL, SINGLE-DOSE (10019-935-25)

10019- Baxter Healthcare Corporation
- 10019-936- CYCLOPHOSPHAMIDE
  - 10019-936-01- 1 VIAL, SINGLE-DOSE in 1 CARTON (10019-936-01) / 50 mL in 1 VIAL, SINGLE-DOSE (10019-936-50)

10019- Baxter Healthcare Corporation
- 10019-937- CYCLOPHOSPHAMIDE
  - 10019-937-01- 1 VIAL, SINGLE-DOSE in 1 CARTON (10019-937-01) / 100 mL in 1 VIAL, SINGLE-DOSE (10019-937-10)

10019- Baxter Healthcare Corporation
- 10019-938- CYCLOPHOSPHAMIDE
  - 10019-938-01- 1 VIAL, SINGLE-DOSE in 1 CARTON (10019-938-01) / 25 mL in 1 VIAL, SINGLE-DOSE (10019-938-25)

10019- Baxter Healthcare Corporation
- 10019-939- CYCLOPHOSPHAMIDE
  - 10019-939-01- 1 VIAL, SINGLE-DOSE in 1 CARTON (10019-939-01) / 50 mL in 1 VIAL, SINGLE-DOSE (10019-939-50)

10019- Baxter Healthcare Corporation
- 10019-942- CYCLOPHOSPHAMIDE
  - 10019-942-01- 1 VIAL, SINGLE-DOSE in 1 CARTON (10019-942-01) / 100 mL in 1 VIAL, SINGLE-DOSE (10019-942-10)

10019- Baxter Healthcare Corporation
- 10019-943- CYCLOPHOSPHAMIDE
  - 10019-943-01- 1 VIAL, SINGLE-DOSE in 1 CARTON (10019-943-01) / 25 mL in 1 VIAL, SINGLE-DOSE (10019-943-25)

10019- Baxter Healthcare Corporation
- 10019-944- CYCLOPHOSPHAMIDE
  - 10019-944-01- 1 VIAL, SINGLE-DOSE in 1 CARTON (10019-944-01) / 50 mL in 1 VIAL, SINGLE-DOSE (10019-944-50)

10019- Baxter Healthcare Corporation
- 10019-945- CYCLOPHOSPHAMIDE
  - 10019-945-01- 1 VIAL, SINGLE-DOSE in 1 CARTON (10019-945-01) / 100 mL in 1 VIAL, SINGLE-DOSE (10019-945-10)

10019- Baxter Healthcare Corporation
- 10019-955- Cyclophosphamide
  - 10019-955-01- 1 VIAL, SINGLE-DOSE in 1 CARTON (10019-955-01) / 25 mL in 1 VIAL, SINGLE-DOSE (10019-955-50)

10019- Baxter Healthcare Corporation
- 10019-956- Cyclophosphamide
  - 10019-956-01- 1 VIAL, SINGLE-DOSE in 1 CARTON (10019-956-01) / 50 mL in 1 VIAL, SINGLE-DOSE (10019-956-16)

10019- Baxter Healthcare Corporation
- 10019-957- Cyclophosphamide
  - 10019-957-01- 1 VIAL, SINGLE-DOSE in 1 CARTON (10019-957-01) / 100 mL in 1 VIAL, SINGLE-DOSE (10019-957-11)

10019- Baxter Healthcare Company
- 10019-982- Cyclophosphamide
  - 10019-982-01- 1 BOTTLE in 1 CARTON (10019-982-01) / 100 TABLET in 1 BOTTLE (10019-982-09)

10019- Baxter Healthcare Company
- 10019-984- Cyclophosphamide
  - 10019-984-01- 1 BOTTLE in 1 CARTON (10019-984-01) / 100 TABLET in 1 BOTTLE (10019-984-09)

14335- Hainan Poly Pharm. Co., Ltd.
- 14335-360-
  - 14335-360-04- 25 kg in 1 DRUM (14335-360-04)

14593- Emcure Pharmaceuticals Limited
- 14593-910-
  - 14593-910-01- 5 kg in 1 JAR (14593-910-01)

14593- Emcure Pharmaceuticals Limited
- 14593-910-
  - 14593-910-02- 15 kg in 1 DRUM (14593-910-02)

14593- Emcure Pharmaceuticals Limited
- 14593-910-
  14593-910-03- 50 kg in 1 DRUM (14593-910-03)

14593- Emcure Pharmaceuticals Limited
- 14593-910-
  14593-910-04- 1 kg in 1 POUCH (14593-910-04)

14593- Emcure Pharmaceuticals Limited
- 14593-910-
  14593-910-05- 6 kg in 1 DRUM (14593-910-05)

15308- Aarti Pharmalabs Limited
- 15308-0921-
  15308-0921-0- 5 kg in 1 BAG (15308-0921-0)

16714- NorthStar Rx LLC
- 16714-857- Cyclophosphamide
  16714-857-01- 1 VIAL, SINGLE-DOSE in 1 CARTON (16714-857-01) / 50 mL in 1 VIAL, SINGLE-DOSE

16714- NorthStar Rx LLC
- 16714-858- Cyclophosphamide
  - 16714-858-01- 1 VIAL, SINGLE-DOSE in 1 CARTON (16714-858-01) / 100 mL in 1 VIAL, SINGLE-DOSE

16714- NorthStar Rx LLC
- 16714-859- Cyclophosphamide
  - 16714-859-01- 1 VIAL, SINGLE-DOSE in 1 CARTON (16714-859-01) / 25 mL in 1 VIAL, SINGLE-DOSE

25021- Sagent Pharmaceuticals
- 25021-247- Cyclophosphamide
  - 25021-247-50- 1 VIAL in 1 CARTON (25021-247-50) / 25 mL in 1 VIAL

25021- Sagent Pharmaceuticals
- 25021-248- Cyclophosphamide
  - 25021-248-51- 1 VIAL in 1 CARTON (25021-248-51) / 50 mL in 1 VIAL

25021- Sagent Pharmaceuticals
- 25021-249- Cyclophosphamide
  - 25021-249-51- 1 VIAL in 1 CARTON (25021-249-51) / 100 mL in 1 VIAL

38779- Medisca Inc.
- 38779-0506-
  - 38779-0506-3- 5 g in 1 BOTTLE, GLASS (38779-0506-3)

38779- Medisca Inc.
- 38779-0506-
  38779-0506-4- 25 g in 1 BOTTLE, GLASS (38779-0506-4)

38779- Medisca Inc.
- 38779-0506-
  38779-0506-5- 100 g in 1 BOTTLE, GLASS (38779-0506-5)

39822- XGen Pharmaceuticals DJB, Inc.
- 39822-0250- CYCLOPHOSPHAMIDE
  39822-0250-1- 1 VIAL, SINGLE-DOSE in 1 CARTON (39822-0250-1) / 25 mL in 1 VIAL, SINGLE-DOSE

39822- XGen Pharmaceuticals DJB, Inc.
- 39822-0255- CYCLOPHOSPHAMIDE
  - 39822-0255-1- 1 VIAL, SINGLE-DOSE in 1 CARTON (39822-0255-1) / 50 mL in 1 VIAL, SINGLE-DOSE

39822- XGen Pharmaceuticals DJB, Inc.
- 39822-0260- CYCLOPHOSPHAMIDE
  - 39822-0260-1- 1 VIAL, SINGLE-DOSE in 1 CARTON (39822-0260-1) / 100 mL in 1 VIAL, SINGLE-DOSE

42973- Apicore Pharmaceuticals Private Limited
- 42973-318-
  - 42973-318-00- 50 kg in 1 DRUM (42973-318-00)

46708- Alembic Pharmaceuticals Limited
- 46708-618- Cyclophosphamide
  46708-618-31- 100 CAPSULE in 1 BOTTLE (46708-618-31)

46708- Alembic Pharmaceuticals Limited
- 46708-619- Cyclophosphamide
  - 46708-619-31- 100 CAPSULE in 1 BOTTLE (46708-619-31)

51927- Professional Compounding Centers of America dba PCCA
- 51927-4871-
  - 51927-4871-0- 1 kg in 1 CONTAINER (51927-4871-0)

54879- STI Pharma LLC
- 54879-021- CYCLOPHOSPHAMIDE
  54879-021-01- 100 CAPSULE in 1 BOTTLE (54879-021-01)

54879- STI Pharma LLC
- 54879-022- CYCLOPHOSPHAMIDE
  - 54879-022-01- 100 CAPSULE in 1 BOTTLE (54879-022-01)

55150- Eugia US LLC
- 55150-270- Cyclophosphamide
  - 55150-270-99- 1 VIAL, MULTI-DOSE in 1 CARTON (55150-270-99) / 2.5 mL in 1 VIAL, MULTI-DOSE

55150- Eugia US LLC
- 55150-271- Cyclophosphamide
  - 55150-271-99- 1 VIAL, MULTI-DOSE in 1 CARTON (55150-271-99) / 5 mL in 1 VIAL, MULTI-DOSE

55150- Eugia US LLC
- 55150-272- Cyclophosphamide
  - 55150-272-01- 1 VIAL, MULTI-DOSE in 1 CARTON (55150-272-01) / 10 mL in 1 VIAL, MULTI-DOSE

57821- Agno Pharma Jiangsu
- 57821-004-
  - 57821-004-01- 5400 VIAL, GLASS in 1 CANISTER (57821-004-01) / 500 mg in 1 VIAL, GLASS

57821- Agno Pharma Jiangsu
- 57821-004-
  57821-004-02- 2700 VIAL, GLASS in 1 CANISTER (57821-004-02) / 1000 mg in 1 VIAL, GLASS

57821- Agno Pharma Jiangsu
- 57821-004-
  57821-004-03- 2700 VIAL, GLASS in 1 CANISTER (57821-004-03) / 1000 mg in 1 VIAL, GLASS

57821- Agno Pharma Jiangsu
- 57821-004-
  57821-004-04- 1350 VIAL, GLASS in 1 CANISTER (57821-004-04) / 2000 mg in 1 VIAL, GLASS

57884- Jiangsu Hengrui Pharmaceuticals Co., Ltd.
- 57884-0022-
  57884-0022-1- 1 kg in 1 PACKAGE (57884-0022-1)

58621- Piramal Pharma Solutions Inc.
- 58621-009-
  58621-009-01- 2.5 mL in 1 VIAL (58621-009-01)

58621- Piramal Pharma Solutions Inc.
- 58621-010-
  58621-010-01- 5 mL in 1 VIAL (58621-010-01)

58623- Zhejiang Hisun Pharmaceutical Co., Ltd.
- 58623-0024-
  58623-0024-1- 1 kg in 1 DRUM (58623-0024-1)

58623- Zhejiang Hisun Pharmaceutical Co., Ltd.
- 58623-0024-
  58623-0024-5- 5 kg in 1 DRUM (58623-0024-5)

62332- Alembic Pharmaceuticals Inc.
- 62332-618- Cyclophosphamide
  62332-618-31- 100 CAPSULE in 1 BOTTLE (62332-618-31)

62332- Alembic Pharmaceuticals Inc.
- 62332-619- Cyclophosphamide
  - 62332-619-31- 100 CAPSULE in 1 BOTTLE (62332-619-31)

65219- Fresenius Kabi USA, LLC
- 65219-131- Cyclophosphamide
  - 65219-131-20- 1 VIAL, SINGLE-DOSE in 1 CARTON (65219-131-20) / 50 mL in 1 VIAL, SINGLE-DOSE

65219- Fresenius Kabi USA, LLC
- 65219-133- Cyclophosphamide
  - 65219-133-20- 1 VIAL, SINGLE-DOSE in 1 CARTON (65219-133-20) / 100 mL in 1 VIAL, SINGLE-DOSE

65219- Fresenius Kabi USA, LLC
- 65219-135- Cyclophosphamide
  - 65219-135-20- 1 VIAL, SINGLE-DOSE in 1 CARTON (65219-135-20) / 25 mL in 1 VIAL, SINGLE-DOSE

68001- BluePoint Laboratories
- 68001-442- Cyclophosphamide
  - 68001-442-26- 1 VIAL, SINGLE-DOSE in 1 CARTON (68001-442-26) / 25 mL in 1 VIAL, SINGLE-DOSE

68001- BluePoint Laboratories
- 68001-443- Cyclophosphamide
  - 68001-443-27- 1 VIAL, SINGLE-DOSE in 1 CARTON (68001-443-27) / 50 mL in 1 VIAL, SINGLE-DOSE

68001- BluePoint Laboratories
- 68001-444- Cyclophosphamide
  - 68001-444-32- 1 VIAL, SINGLE-DOSE in 1 CARTON (68001-444-32) / 100 mL in 1 VIAL, SINGLE-DOSE

68001- BluePoint Laboratories
- 68001-564- CYCLOPHOSPHAMIDE
  - 68001-564-22- 1 VIAL in 1 CARTON (68001-564-22) / 5 mL in 1 VIAL

68001- BluePoint Laboratories
- 68001-565- CYCLOPHOSPHAMIDE
  - 68001-565-28- 1 VIAL in 1 CARTON (68001-565-28) / 10 mL in 1 VIAL

68554- Hetero Labs Limited
- 68554-0062-
  - 68554-0062-1- 10 kg in 1 DRUM (68554-0062-1)

69097- Cipla USA Inc.
- 69097-516- Cyclophosphamide
  69097-516-07- 100 CAPSULE in 1 BOTTLE (69097-516-07)

69097- Cipla USA Inc.
- 69097-517- Cyclophosphamide
  - 69097-517-07- 100 CAPSULE in 1 BOTTLE (69097-517-07)

69776- Sunny Pharmtech Inc.
- 69776-906-
  - 69776-906-10- 2 BAG in 1 DRUM (69776-906-10) / 5 kg in 1 BAG

70121- Amneal Pharmaceuticals LLC
- 70121-1238- Cyclophosphamide
  70121-1238-1- 1 VIAL, SINGLE-DOSE in 1 CARTON (70121-1238-1) / 25 mL in 1 VIAL, SINGLE-DOSE

70121- Amneal Pharmaceuticals LLC
- 70121-1239- Cyclophosphamide
  - 70121-1239-1- 1 VIAL, SINGLE-DOSE in 1 CARTON (70121-1239-1) / 50 mL in 1 VIAL, SINGLE-DOSE

70121- Amneal Pharmaceuticals LLC
- 70121-1240- Cyclophosphamide
  - 70121-1240-1- 1 VIAL, SINGLE-DOSE in 1 CARTON (70121-1240-1) / 100 mL in 1 VIAL, SINGLE-DOSE

72572- Civica, Inc.
- 72572-083- Cyclophosphamide
  - 72572-083-01- 1 VIAL, SINGLE-DOSE in 1 CARTON (72572-083-01) / 100 mL in 1 VIAL, SINGLE-DOSE

72572- Civica, Inc.
- 72572-085- Cyclophosphamide
  - 72572-085-01- 1 VIAL, SINGLE-DOSE in 1 CARTON (72572-085-01) / 50 mL in 1 VIAL, SINGLE-DOSE

72572- Civica, Inc.
- 72572-087- Cyclophosphamide
  - 72572-087-01- 1 VIAL, SINGLE-DOSE in 1 CARTON (72572-087-01) / 25 mL in 1 VIAL, SINGLE-DOSE

72603- NorthStar RxLLC
- 72603-104- Cyclophosphamide
  - 72603-104-01- 1 VIAL, SINGLE-DOSE in 1 CARTON (72603-104-01) / 25 mL in 1 VIAL, SINGLE-DOSE

72603- NorthStar RxLLC
- 72603-326- Cyclophosphamide
  - 72603-326-01- 1 VIAL, SINGLE-DOSE in 1 CARTON (72603-326-01) / 50 mL in 1 VIAL, SINGLE-DOSE

72603- NorthStar RxLLC
- 72603-411- Cyclophosphamide
  - 72603-411-01- 1 VIAL, SINGLE-DOSE in 1 CARTON (72603-411-01) / 100 mL in 1 VIAL, SINGLE-DOSE

75907- Dr. Reddy's Labratories Inc.
- 75907-189- CYCLOPHOSPHAMIDE
  - 75907-189-35- 1 VIAL in 1 CARTON (75907-189-35) / 10 mL in 1 VIAL

75907- Dr. Reddy's Labratories Inc.
- 75907-190- CYCLOPHOSPHAMIDE
  - 75907-190-07- 1 VIAL in 1 CARTON (75907-190-07) / 5 mL in 1 VIAL

75907- Dr. Reddy's Labratories Inc.
- 75907-191- CYCLOPHOSPHAMIDE
  - 75907-191-02- 1 VIAL in 1 CARTON (75907-191-02) / 2.5 mL in 1 VIAL

76339- Apothecon Pharmaceuticals Pvt Ltd
- 76339-164-
  - 76339-164-00- .999 kg in 1 CANISTER (76339-164-00)

76339- Apothecon Pharmaceuticals Pvt Ltd
- 76339-164-
  76339-164-01- 4.999 kg in 1 CANISTER (76339-164-01)

76339- Apothecon Pharmaceuticals Pvt Ltd
- 76339-164-
  76339-164-02- 9.999 kg in 1 CANISTER (76339-164-02)

76339- Apothecon Pharmaceuticals Pvt Ltd
- 76339-191-
  76339-191-00- 1 BAG in 1 DRUM (76339-191-00) / 1 BAG in 1 BAG / .999 kg in 1 BAG

76339- Apothecon Pharmaceuticals Pvt Ltd
- 76339-191-
  76339-191-01- 1 BAG in 1 DRUM (76339-191-01) / 1 BAG in 1 BAG / 4.999 kg in 1 BAG

76339- Apothecon Pharmaceuticals Pvt Ltd
- 76339-191-
  76339-191-02- 1 BAG in 1 DRUM (76339-191-02) / 1 BAG in 1 BAG / 9.999 kg in 1 BAG

81955- VALARY LAB PRIVATE LIMITED
- 81955-0004-
  81955-0004-1- 10 kg in 1 DRUM (81955-0004-1)

82920- SHILPA PHARMA LIFESCIENCES LIMITED
- 82920-708-
  82920-708-00- 5000 g in 1 DRUM (82920-708-00)

83703- Bamboo US Bidco LCC
- 83703-549- CYCLOPHOSPHAMIDE
  83703-549-01- 1 VIAL, SINGLE-DOSE in 1 CARTON (83703-549-01) / 25 mL in 1 VIAL, SINGLE-DOSE (83703-549-25)

83703- Bamboo US Bidco LCC
- 83703-550- CYCLOPHOSPHAMIDE
  - 83703-550-01- 1 VIAL, SINGLE-DOSE in 1 CARTON (83703-550-01) / 50 mL in 1 VIAL, SINGLE-DOSE (83703-550-50)

83703- Bamboo US Bidco LCC
- 83703-551- CYCLOPHOSPHAMIDE
  - 83703-551-01- 1 VIAL, SINGLE-DOSE in 1 CARTON (83703-551-01) / 100 mL in 1 VIAL, SINGLE-DOSE (83703-551-10)

83831- Avyxa Pharma, LLC
- 83831-116- Cyclophosphamide
  - 83831-116-01- 1 VIAL, SINGLE-DOSE in 1 CARTON (83831-116-01) / 1 mL in 1 VIAL, SINGLE-DOSE

83831- Avyxa Pharma, LLC
- 83831-117- Cyclophosphamide
  - 83831-117-02- 1 VIAL, SINGLE-DOSE in 1 CARTON (83831-117-02) / 2 mL in 1 VIAL, SINGLE-DOSE

83831- Avyxa Pharma, LLC
- 83831-118- Cyclophosphamide
  - 83831-118-04- 1 VIAL, SINGLE-DOSE in 1 CARTON (83831-118-04) / 4 mL in 1 VIAL, SINGLE-DOSE

83831- Avyxa Pharma, LLC
- 83831-119- Frindovyx
  - 83831-119-01- 1 VIAL, MULTI-DOSE in 1 CARTON (83831-119-01) / 1 mL in 1 VIAL, MULTI-DOSE

83831- Avyxa Pharma, LLC
- 83831-120- Frindovyx
  - 83831-120-02- 1 VIAL, MULTI-DOSE in 1 CARTON (83831-120-02) / 2 mL in 1 VIAL, MULTI-DOSE

section name header

Pronunciation ⬇

Classifications ⬆ ⬇

Indications ⬆ ⬇

Action ⬆ ⬇

Pharmacokinetics ⬆ ⬇

Time/Action Profile ⬆ ⬇

Contraind./Precautions ⬆ ⬇

Adv. Reactions/Side Effects ⬆ ⬇

Interactions ⬆ ⬇

Route/Dosage ⬆ ⬇

Availability ⬆ ⬇

Assessment ⬆ ⬇

Implementation ⬆ ⬇

Patient/Family Teaching ⬆ ⬇

Evaluation/Desired Outcomes ⬆ ⬇

US Brand Names ⬆ ⬇

Canadian Brand Names ⬆ ⬇

Code ⬆