si-TAL-oh-pram
Therapeutic Classification: antidepressants
Pharmacologic Classification: selective serotonin reuptake inhibitors ssris
BEERS REMS
Absorption: 80% absorbed after oral administration.
Distribution: Enters breast milk.
Half-Life: 35 hr.
Contraindicated in:
Use Cautiously in:
May ↑ risk of suicide attempt/ideation especially during early treatment or dose adjustment; this risk appears to be greater in adolescents or children
;CV: QT interval prolongation, postural hypotension, tachycardia, TORSADES DE POINTES
Derm: sweating, photosensitivity, pruritus, rash
EENT: abnormal accommodation
Endo: SIADH
F and E: hyponatremia
GI: ↑salivation, abdominal pain, anorexia, diarrhea, dry mouth, dyspepsia, flatulence, nausea, altered taste, vomiting
GU: ↓libido, amenorrhea, delayed/absent orgasm, dysmenorrhea, ejaculatory delay/failure, erectile dysfunction, polyuria
Hemat: BLEEDING
MS: arthralgia, myalgia
Neuro: apathy, confusion, drowsiness, insomnia, tremor, weakness, ↓libido, ↑depression, agitation, amnesia, anxiety, dizziness, fatigue, impaired concentration, migraine headache, NEUROLEPTIC MALIGNANT SYNDROME, paresthesia, SUICIDAL THOUGHTS/BEHAVIORS
Resp: cough
Misc: fever, SEROTONIN SYNDROME, yawning
Drug-drug:
Drug-Natural Products:
Hepatic Impairment
Assess for suicidal tendencies, especially during early therapy and dose changes. Restrict amount of drug available to patient. Risk may be ↑ in children, adolescents, and adults ≤24 yr. After starting therapy, young adults should be seen by health care provider at least weekly for 4 wk, every 3 wk for the next 4 wk, and on advice of health care provider thereafter.
Lab Test Considerations:
Advise patient, family, and caregivers to look for suicidality, especially during early therapy or dose changes. Notify health care provider immediately if thoughts about suicide or dying, attempts to commit suicide, new or worse depression or anxiety, agitation or restlessness, panic attacks, insomnia, new or worse irritability, aggressiveness, acting on dangerous impulses, mania, or other changes in mood or behavior.
NDC Code
