zafirlukast

Therapeutic Classification: antiasthmatics, bronchodilators

Pharmacologic Classification: leukotriene antagonists

REMS

Long-term control agent in the management of asthma.

Antagonizes the effects of leukotrienes, which are components of slow-reacting substance of anaphylaxis (SRSA).
These substances mediate the following:
- Airway edema,
- Smooth muscle constriction,
- Altered cellular activity.
Result is decreased inflammatory process that is part of asthma.

Therapeutic effects:

Decreased frequency and severity of asthma.

Absorption: Rapidly absorbed after oral administration.

Distribution: Enters breast milk.

Protein Binding: 99%.

Metabolism/Excretion: Mostly metabolized by the liver; 10% excreted unchanged by the kidneys.

Half-Life: 10 hr.

(improved symptoms of asthma)

ROUTE	ONSET	PEAK	DURATION
PO	unknown	1 wk	unknown

Contraindicated in:

Hypersensitivity;
Hepatic impairment;
Lactation: Lactation.

Use Cautiously in:

Acute attacks of asthma;
Patients >55 yr (↑ risk of infection);
Geri: May need lower doses to avoid side effects;
OB: Pregnancy or children <7 yr (safety not established).

CNS: SUICIDAL THOUGHTS, headache, agitation, aggression, anxiety, depression, dizziness, dream abnormalities, hallucinations, insomnia, irritability, restlessness, tremor, weakness

GI: HEPATOTOXICITY, abdominal pain, diarrhea, dyspepsia, nausea, vomiting

MS: arthralgia, back pain, myalgia

Misc: CHURG-STRAUSS SYNDROME, fever, infection (geriatric patients), pain

Drug-drug:

Levels are ↑ by aspirin and fluconazole.
Levels are ↓ by erythromycin and theophylline.
↑effects and risk of bleeding with warfarin.

Drug-Food:

Food (especially high-fat or high-protein meal) ↓ absorption.

PO (Adults and Children ≥12 yr): 20 mg twice daily.
PO (Children 7–11 yr): 10 mg twice daily.

Tablets: 10 mg; 20 mg

Assess lung sounds and respiratory function before and periodically during therapy.
Monitor closely for changes in behavior that could indicate the emergence or worsening of depression or suicidal thoughts.

Lab Test Considerations:

Monitor liver function periodically during therapy. May cause ↑ ALT concentrations. If liver dysfunction occurs, zafirlukast should be discontinued.

PO: Administer at regular intervals on an empty stomach, 1 hr before or 2 hr after meals.

Instruct patient to take medication on an empty stomach as directed, at evenly spaced intervals, even if not experiencing symptoms of asthma. Take missed doses as soon as remembered unless almost time for next dose. Do not double doses. Do not discontinue therapy without consulting health care professional.
Instruct patient not to discontinue or reduce other asthma medications without consulting health care professional.
Advise patient that zafirlukast is not used to treat acute asthma attacks but may be continued during an acute exacerbation.
Advise patient, family, and caregivers to look for suicidality, especially during early therapy or dose changes. Notify health care professional immediately if thoughts about suicide or dying, attempts to commit suicide, new or worse depression or anxiety, agitation or restlessness, panic attacks, insomnia, new or worse irritability, aggressiveness, acting on dangerous impulses, mania, or other changes in mood or behavior occur.
Advise patient to notify health care professional if symptoms of Churg-Strauss syndrome (generalized flu-like syndrome, fever, muscle aches and pain, weight loss, worsening respiratory symptoms) occur. Occurs rarely but may be life-threatening. More likely to occur when weaning from systemic corticosteroids.

Prevention of and reduction in symptoms of asthma.

Ineffective airway clearance(Indications)
Deficient knowledge, Relate med(Patient/Family Teaching)

NDC Code

31722- Camber Pharmaceuticals, Inc.
- 31722-007- Zafirlukast
  - 31722-007-01- 10 BLISTER PACK in 1 CARTON (31722-007-01) / 10 TABLET, FILM COATED in 1 BLISTER PACK

31722- Camber Pharmaceuticals, Inc.
- 31722-007- Zafirlukast
  - 31722-007-05- 500 TABLET, FILM COATED in 1 BOTTLE (31722-007-05)

31722- Camber Pharmaceuticals, Inc.
- 31722-007- Zafirlukast
  - 31722-007-60- 60 TABLET, FILM COATED in 1 BOTTLE (31722-007-60)

31722- Camber Pharmaceuticals, Inc.
- 31722-008- Zafirlukast
  - 31722-008-01- 10 BLISTER PACK in 1 CARTON (31722-008-01) / 10 TABLET, FILM COATED in 1 BLISTER PACK

31722- Camber Pharmaceuticals, Inc.
- 31722-008- Zafirlukast
  - 31722-008-05- 500 TABLET, FILM COATED in 1 BOTTLE (31722-008-05)

31722- Camber Pharmaceuticals, Inc.
- 31722-008- Zafirlukast
  - 31722-008-60- 60 TABLET, FILM COATED in 1 BOTTLE (31722-008-60)

42291- AvKARE
- 42291-970- Zafirlukast
  - 42291-970-60- 60 TABLET, COATED in 1 BOTTLE (42291-970-60)

42291- AvKARE
- 42291-971- Zafirlukast
  - 42291-971-60- 60 TABLET, COATED in 1 BOTTLE (42291-971-60)

50370- MSN Pharmachem Private Limited
- 50370-0008-
  - 50370-0008-1- 60 kg in 1 DRUM (50370-0008-1)

52562- Chromo Laboratories India Private Limited
- 52562-800-
  - 52562-800-01- 50 kg in 1 CONTAINER (52562-800-01)

52562- Chromo Laboratories India Private Limited
- 52562-801-
  - 52562-801-01- 50 kg in 1 CONTAINER (52562-801-01)

55111- Dr. Reddys Laboratories Limited
- 55111-625- Zafirlukast
  55111-625-01- 100 TABLET, FILM COATED in 1 BOTTLE (55111-625-01)

55111- Dr. Reddys Laboratories Limited
- 55111-625- Zafirlukast
  - 55111-625-05- 500 TABLET, FILM COATED in 1 BOTTLE (55111-625-05)

55111- Dr. Reddys Laboratories Limited
- 55111-625- Zafirlukast
  - 55111-625-30- 30 TABLET, FILM COATED in 1 BOTTLE (55111-625-30)

55111- Dr. Reddys Laboratories Limited
- 55111-625- Zafirlukast
  - 55111-625-60- 60 TABLET, FILM COATED in 1 BOTTLE (55111-625-60)

55111- Dr. Reddys Laboratories Limited
- 55111-625- Zafirlukast
  - 55111-625-78- 10 BLISTER PACK in 1 CARTON (55111-625-78) / 10 TABLET, FILM COATED in 1 BLISTER PACK (55111-625-79)

55111- Dr. Reddys Laboratories Limited
- 55111-626- Zafirlukast
  - 55111-626-01- 100 TABLET, FILM COATED in 1 BOTTLE (55111-626-01)

55111- Dr. Reddys Laboratories Limited
- 55111-626- Zafirlukast
  - 55111-626-05- 500 TABLET, FILM COATED in 1 BOTTLE (55111-626-05)

55111- Dr. Reddys Laboratories Limited
- 55111-626- Zafirlukast
  - 55111-626-30- 30 TABLET, FILM COATED in 1 BOTTLE (55111-626-30)

55111- Dr. Reddys Laboratories Limited
- 55111-626- Zafirlukast
  - 55111-626-60- 60 TABLET, FILM COATED in 1 BOTTLE (55111-626-60)

55111- Dr. Reddys Laboratories Limited
- 55111-626- Zafirlukast
  - 55111-626-78- 10 BLISTER PACK in 1 CARTON (55111-626-78) / 10 TABLET, FILM COATED in 1 BLISTER PACK (55111-626-79)

55111- Dr.Reddy's Laboratories Limited
- 55111-886-
  - 55111-886-00- 1 kg in 1 DRUM (55111-886-00)

59651- Aurobindo Pharma Limited
- 59651-291- Zafirlukast
  59651-291-60- 60 TABLET, FILM COATED in 1 BOTTLE (59651-291-60)

59651- Aurobindo Pharma Limited
- 59651-291-
  - 59651-291-73- 7000 TABLET, FILM COATED in 1 BAG (59651-291-73)

59651- Aurobindo Pharma Limited
- 59651-292-
  59651-292-59- 5000 TABLET, FILM COATED in 1 BAG (59651-292-59)

59651- Aurobindo Pharma Limited
- 59651-292- Zafirlukast
  59651-292-60- 60 TABLET, FILM COATED in 1 BOTTLE (59651-292-60)

64380- Strides Pharma Science Limited
- 64380-177- ACCOLATE
  - 64380-177-01- 60 TABLET, FILM COATED in 1 BOTTLE (64380-177-01)

64380- Strides Pharma Science Limited
- 64380-178- ACCOLATE
  - 64380-178-01- 60 TABLET, FILM COATED in 1 BOTTLE (64380-178-01)

64380- Strides Pharma Science Limited
- 64380-187- Zafirlukast
  - 64380-187-01- 60 TABLET, COATED in 1 BOTTLE (64380-187-01)

64380- Strides Pharma Science Limited
- 64380-188- Zafirlukast
  - 64380-188-01- 60 TABLET, COATED in 1 BOTTLE (64380-188-01)

65977- Hetero Drugs Limited
- 65977-0113-
  - 65977-0113-1- 5 kg in 1 DRUM (65977-0113-1)

68084- American Health Packaging
- 68084-059- Zafirlukast
  68084-059-21- 30 BLISTER PACK in 1 BOX, UNIT-DOSE (68084-059-21) / 1 TABLET, FILM COATED in 1 BLISTER PACK (68084-059-11)

70054- Par Active Technologies Private Limited
- 70054-006-
  - 70054-006-01- 30 kg in 1 DRUM (70054-006-01)

72162- Bryant Ranch Prepack
- 72162-2361- Zafirlukast
  72162-2361-6- 60 TABLET, FILM COATED in 1 BOTTLE (72162-2361-6)

72162- Bryant Ranch Prepack
- 72162-2362- Zafirlukast
  - 72162-2362-6- 60 TABLET, COATED in 1 BOTTLE (72162-2362-6)

section name header

Pronunciation ⬇

Classifications ⬆ ⬇

Indications ⬆ ⬇

Action ⬆ ⬇

Pharmacokinetics ⬆ ⬇

Time/Action Profile ⬆ ⬇

Contraind./Precautions ⬆ ⬇

Adv. Reactions/Side Effects ⬆ ⬇

Interactions ⬆ ⬇

Route/Dosage ⬆ ⬇

Availability ⬆ ⬇

Assessment ⬆ ⬇

Implementation ⬆ ⬇

Patient/Family Teaching ⬆ ⬇

Evaluation/Desired Outcomes ⬆ ⬇

US Brand Names ⬆ ⬇

Pot. Nursing Diagnoses ⬆ ⬇

Code ⬆