section name header

Pronunciation ⬇

ER-soe-dye-ole

Classifications ⬆ ⬇

Therapeutic Classification: gallstone dissolution agents

Indications ⬆ ⬇

REMS

Unlabeled Use:

Action ⬆ ⬇

  • ↓cholesterol content of bile and bile stones by suppressing cholesterol synthesis and secretion from the liver and inhibits intestinal absorption of cholesterol.
Therapeutic effects:
  • Gallstone dissolution and reduction in gallstone formation.
  • ↓progression of liver disease and improvement in liver function tests.

Pharmacokinetics ⬆ ⬇

Absorption: 90%.

Distribution: Only small quantities are found in the systemic circulation; sites of action include the liver, bile, and gut lumen.

Protein Binding: 70%.

Metabolism/Excretion: Undergoes extensive enterohepatic recycling; excreted in feces via bile.

Half-Life: 100 hr.

Time/Action Profile ⬆ ⬇

ROUTEONSETPEAKDURATION
POunknownunknownunknown

Contraind./Precautions ⬆ ⬇

Contraindicated in:

Use Cautiously in:

Adv. Reactions/Side Effects ⬆ ⬇

CNS: anxiety, depression, fatigue, headache, sleep disorder

Derm: hair thinning, pruritus, rash

GI: abdominal/biliary pain, constipation, diarrhea, flatulence, jaundice, ↑liver enzymes, nausea, stomatitis, vomiting

Neuro: arthralgias, myalgia

Resp: cough, rhinitis

Interactions ⬆ ⬇

Drug-drug:

Route/Dosage ⬆ ⬇

Availability ⬆ ⬇

(Generic available)

Assessment ⬆ ⬇

Lab Test Considerations:

Implementation ⬆ ⬇

Patient/Family Teaching ⬆ ⬇

Evaluation/Desired Outcomes ⬆ ⬇

US Brand Names ⬆ ⬇

Actigall, Urso 250, Urso Forte

Canadian Brand Names ⬆ ⬇

Urso, Urso DS

Pot. Nursing Diagnoses ⬆ ⬇

Code ⬆

NDC Code