doe-se-TAX-el
High Alert
Absorption: IV administration results in complete bioavailability.
Distribution: Widely distributed to tissues.
Half-Life: 116 hr.
Contraindicated in:
Use Cautiously in:
CV: peripheral edema, CARDIAC TAMPONADE, PERICARDIAL EFFUSION
Derm: alopecia, edema, rash, ACUTE GENERALIZED EXANTHEMATOUS PUSTULOSIS (AGEP), dermatitis, desquamation, erythema, nail disorders, STEVENS-JOHNSON SYNDROME (SJS), TOXIC EPIDERMAL NECROLYSIS (TEN)
EENT: cystoid macular edema
GI: diarrhea, nausea, stomatitis, vomiting, ASCITES, ENTEROCOLITIS, NEUTROPENIC COLITIS
GU: ↓fertility (men), amenorrhea
Hemat: anemia, leukopenia, thrombocytopenia
Local: injection site reactions
MS: myalgia, arthralgia
Neuro: fatigue, weakness, alcohol intoxication, neurosensory deficits, peripheral neuropathy
Resp: ACUTE RESPIRATORY DISTRESS SYNDROME, bronchospasm, dyspnea, INTERSTITIAL LUNG DISEASE, PULMONARY EDEMA, PULMONARY FIBROSIS
Misc: HYPERSENSITIVITY REACTIONS (INCLUDING ANAPHYLAXIS), MALIGNANCY (INCLUDING LEUKEMIAS, MYELODYSPLASTIC SYNDROME, NON-HODGKIN LYMPHOMA, AND RENAL CANCER), tumor lysis syndrome
Drug-drug:
Locally Advanced or Metastatic Breast Cancer
Adjuvant Treatment of Operable Node-Positive Breast Cancer
Non-Small Cell Lung Cancer, Metastatic Castration-Resistant Prostate Cancer, or Advanced Gastric Adenocarcinoma
Locally Advanced Squamous Cell Carcinoma of the Head and Neck
Lab Test Considerations:
IV Administration:
Docetaxel is a vesicant. If extravasation occurs, immediately stop infusion. Leave needle/cannula in place temporarily but do not flush the line. Gently aspirate extravasated solution; then remove needle/cannula. Elevate patient's extremity and apply dry cold compresses for 20 min 4 times day for 1–2 days.
NDC Code