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Pronunciation ⬇

klor-PROE-ma-zeen

Classifications ⬆ ⬇

Therapeutic Classification: antiemetics, antipsychotics

Pharmacologic Classification: phenothiazines

Indications ⬆ ⬇

BEERS REMS


Action ⬆ ⬇

  • Alters the effects of dopamine in the CNS.
  • Has significant anticholinergic/alpha-adrenergic blocking activity.
Therapeutic effects:
  • Diminished signs/symptoms of psychosis and bipolar disorder.
  • Relief of nausea/vomiting/intractable hiccups.
  • Decreased symptoms of porphyria.

Pharmacokinetics ⬆ ⬇

Absorption: Variable absorption from tablets. Well absorbed following IM administration.

Distribution: Widely distributed; high CNS concentrations.

Protein Binding: ≥90%.

Metabolism/Excretion: Highly metabolized by the liver and GI mucosa. Some metabolites are active.

Half-Life: 30 hr.

Time/Action Profile ⬆ ⬇

(antipsychotic activity, antiemetic activity, sedation)

ROUTEONSETPEAKDURATION
PO30–60 minunknown4–6 hr
IMunknownunknown4–8 hr
IVrapidunknownunknown

Contraind./Precautions ⬆ ⬇

Contraindicated in:

Use Cautiously in:

Adv. Reactions/Side Effects ⬆ ⬇

CV: hypotension (↑ with IM, IV), tachycardia

Derm: photosensitivity, pigment changes, rash

EENT: blurred vision, dry eyes, lens opacities

Endo: amenorrhea, galactorrhea

GI: constipation, dry mouth, anorexia, hepatitis, ileus, priapism

GU: urinary retention

Hemat: AGRANULOCYTOSIS, leukopenia

Metab: hyperthermia

Neuro: sedation, extrapyramidal reactions, NEUROLEPTIC MALIGNANT SYNDROME, tardive dyskinesia

Misc: allergic reactions

Interactions ⬆ ⬇

Drug-drug:

Drug-Natural Products:

Route/Dosage ⬆ ⬇

Availability ⬆ ⬇

(Generic available)

Assessment ⬆ ⬇

Lab Test Considerations:

Implementation ⬆ ⬇

IV Administration:

Patient/Family Teaching ⬆ ⬇

Evaluation/Desired Outcomes ⬆ ⬇

US Brand Names ⬆ ⬇

Thorazine

Code ⬆

NDC Code