na-PROX-en
Therapeutic Classification: antipyretics, antirheumatics, nonopioid analgesics
Pharmacologic Classification: nonsteroidal anti inflammatory drugs nsaids
Absorption: Completely absorbed from the GI tract. Sodium salt is more rapidly absorbed.
Distribution: Well distributed to tissues.
Protein Binding: >99%.
Half-Life: Children <8 yr: 8–17 hr; Children 8–14 yr: 8–10 hr; Adults: 10–20 hr.
Contraindicated in:
Use Cautiously in:
CV: edema, HF, hypertension, MI, palpitations, tachycardia
Derm: ↑sweating, DRUG REACTION WITH EOSINOPHILIA AND SYSTEMIC SYMPTOMS (DRESS), EXFOLIATIVE DERMATITIS, rash, GENERALIZED BULLOUS FIXED DRUG ERUPTION, photosensitivity, pseudoporphyria (↑ in children with juvenile rheumatoid arthritis), rash, STEVENS-JOHNSON SYNDROME (SJS), TOXIC EPIDERMAL NECROLYSIS (TEN)
EENT: tinnitus, visual disturbances
F and E: hyperkalemia
GI: constipation, dyspepsia, nausea, anorexia, diarrhea, discomfort, flatulence, GI BLEEDING, GI PERFORATION, GI ULCERATION, HEPATITIS, vomiting
GU: cystitis, hematuria, renal failure
Hemat: blood dyscrasias, prolonged bleeding time
Neuro: dizziness, drowsiness, headache, STROKE
Resp: dyspnea
Misc: HYPERSENSITIVITY REACTIONS (INCLUDING ANAPHYLAXIS AND SERIOUS SKIN REACTIONS)
Drug-drug:
Drug-Natural Products:
Anti-inflammatory/Analgesic/Antidysmenorrheal
OTC Use (Naproxen Sodium)
Naproxen
(Generic available)Naproxen Sodium
(Generic available)Lab Test Considerations:
NDC Code
