ter-i-FLOO-noe-mide
Therapeutic Classification: anti-multiple sclerosis agents
Pharmacologic Classification: immune response modifiers, pyrimidine synthesis inhibitors
REMS
Absorption: Well absorbed following oral administration.
Distribution: Well distributed to tissues.
Protein Binding: >99%.
Half-Life: 18–19 days.
Contraindicated in:
Use Cautiously in:
CV: hypertension
Derm: alopecia, DRUG REACTION WITH EOSINOPHILIA AND SYSTEMIC SYMPTOMS (DRESS), STEVENS-JOHNSON SYNDROME (SJS), TOXIC EPIDERMAL NECROLYSIS (TEN)
F and E: hyperkalemia, hypophosphatemia
GI: ↑liver enzymes, diarrhea, nausea, HEPATOTOXICITY
GU: acute renal failure (urate nephropathy)
Hemat: leukopenia, neutropenia, thrombocytopenia
Neuro: paresthesia, peripheral neuropathy
Misc: HYPERSENSITIVITY REACTIONS (INCLUDING ANAPHYLAXIS, ANGIOEDEMA, AND URTICARIA), INFECTION (INCLUDING LATENT TUBERCULOSIS [TB] AND VIRAL INFECTIONS)
Drug-drug:
Lab Test Considerations:
NDC Code