section name header

Pronunciation ⬇

a-ZEL-as-teen

Classifications ⬆ ⬇

Therapeutic Classification: allergy, cold and cough remedies, antihistamines

Indications ⬆ ⬇

REMS

Action ⬆ ⬇

  • Locally antagonizes the effects of histamine at H1-receptor sites; does not bind to or inactivate histamine.
Therapeutic effects:
  • Decreased sneezing, nasal rhinitis, pruritus and postnasal drip.

Pharmacokinetics ⬆ ⬇

Absorption: 40% absorbed after intranasal administration.

Distribution: Widely distributed to tissues.

Metabolism/Excretion: Most of absorbed azelastine is metabolized by the liver (converted to an active metabolite.

Half-Life: 22–25 hr.

Time/Action Profile ⬆ ⬇

(relief of symptoms)

ROUTEONSETPEAKDURATION
Intranasalrapid2–3 hr‡12 hr

‡Plasma concentration.

Contraind./Precautions ⬆ ⬇

Contraindicated in:

Use Cautiously in:

Adv. Reactions/Side Effects ⬆ ⬇

EENT: epistaxis, nasal burning, pharyngitis, sinusitis, sneezing

GI: bitter taste, dry mouth, nausea

Metab: ↑weight

MS: myalgia

Neuro: drowsiness, dizziness, dysesthesia, fatigue, headache

Interactions ⬆ ⬇

Drug-drug:

Drug-Natural Products:

Route/Dosage ⬆ ⬇

Availability ⬆ ⬇

(Generic available)

Assessment ⬆ ⬇

Lab Test Considerations:

Implementation ⬆ ⬇

Patient/Family Teaching ⬆ ⬇

Evaluation/Desired Outcomes ⬆ ⬇

US Brand Names ⬆ ⬇

Astepro Allergy

Code ⬆

NDC Code