Therapeutic Classification: antivirals, immune modifiers
Pharmacologic Classification: immune response modifiers
Absorption: Minimal absorption.
Distribution: Action is primarily local.
Metabolism/Excretion: <0.9% excreted in urine and feces.
Half-Life: Unknown.
External Genital Warts
- (Adults and Children ≥12 yr): 5% cream: Apply thin layer to warts at bedtime every other day (3 times weekly); leave on for 6–10 hr, then rinse off with mild soap and water. Use until lesions are completely cleared or up to 16 wk. Zyclara: Apply thin layer of 3.75% cream to warts at bedtime every day; leave on for 8 hr, then rinse off with mild soap and water. Use until lesions are completely cleared or up to 8 wk.
Actinic Keratoses
- (Adults ): 5% cream: Apply thin layer to clean, dry affected area twice weekly; leave on for 8 hr, then rinse off with mild soap and water. Continue for 16 wk. Zyclara: Apply thin layer of 2.5% or 3.75% cream to clean, dry affected area once daily before bedtime; leave on for 8 hr, then rinse off with mild soap and water. Continue for 2 wk, followed by 2 wk without treatment, then begin applying cream again for another 2 wk.
Superficial Basal Cell Carcinoma
- (Adults ): Apply thin layer to clean, dry affected area 5 times per week; leave on for 8 hr, then rinse off with mild soap and water. Continue for 6 wk.
