Various cutaneous fungal infections, including cutaneous candidiasis, tinea pedis (athlete’s foot), tinea cruris (jock itch), tinea corporis (ringworm), and tinea versicolor.
Action⬆⬇
Affects the permeability of the fungal cell wall, allowing leakage of cellular contents.
Therapeutic effects:
Decrease in symptoms of fungal infection.
Pharmacokinetics⬆⬇
Absorption: Absorption through intact skin is minimal.
Distribution: Distribution is primarily local.
Metabolism/Excretion: Systemic metabolism and excretion is negligible with local application.
Half-Life: Not applicable.
Time/Action Profile⬆⬇
ROUTE
ONSET
PEAK
DURATION
Top
unknown
unknown
unknown
Contraind./Precautions⬆⬇
Contraindicated in:
Hypersensitivity to active ingredients, additives, preservatives, or bases.
Use Cautiously in:
Nail and scalp infections (may require additional systemic therapy);
Adv. Reactions/Side Effects⬆⬇
Local: burning, itching, local hypersensitivity reactions, redness, stinging
Interactions⬆⬇
Drug-drug:
None reported.
Route/Dosage⬆⬇
(Adults and Children ≥3 yr): Apply twice daily for 1–4 wk.
Availability⬆⬇
(Generic available)
Cream: 1%OTC
Lotion: 1%OTC
Ointment: 1%OTC
Solution: 1%OTC
In combination with:
betamethasone.
Assessment⬆⬇
Assess involved areas of skin and mucous membranes before and frequently during therapy.If local irritation occurs, consider discontinuing therapy.
Implementation⬆⬇
Topical Apply small amount to clean, dry skin; cover affected area completely. Avoid the use of occlusive dressing.
Patient/Family Teaching⬆⬇
Explain purpose and side effects of medication. Advise patient to read Patient Information before starting therapy.
Emphasize the importance of avoiding the eyes when applying medication.
Advise patient to notify health care professional of all Rx or OTC medications, vitamins, or herbal products being taken and to consult health care professional before taking other medications, especially topicals or new skin products including cosmetics.
Caution patient that some products may stain fabric, skin, or hair.
Patients with athlete’s foot should be taught to wear well-fitting, ventilated shoes, to wash affected areas thoroughly, and to change shoes and socks at least once a day.
Advise patient to notify health care professional if ↑ skin irritation or lack of response to therapy occurs.
Inform patient that early relief of symptoms may be seen in 2–3 days. For tinea cruris and tinea corporis, 2 wk are needed, and for tinea pedis, therapeutic response may take 3–4 wk. Recurrent fungal infections may be a sign of systemic illness.
Rep: Advise women of reproductive potential to notify health care professional if pregnancy is planned or suspected, or if breastfeeding. Caution women not to apply to breasts if breastfeeding unless advised by health care professional.
Evaluation/Desired Outcomes⬆⬇
Decrease in skin irritation.
Resolution of fungal infection.
US Brand Names⬆⬇
Alevazol, Votriza-AL
Canadian Brand Names⬆⬇
Canesten, Clotrimaderm
Code⬆
NDC Code
0054- Hikma Pharmacuticals USA USA Inc.
0054-4146- Clotrimazole
0054-4146-22- 70 LOZENGE in 1 BOTTLE, PLASTIC (0054-4146-22)
0054- Hikma Pharmacuticals USA USA Inc.
0054-4146- Clotrimazole
0054-4146-23- 140 LOZENGE in 1 BOTTLE, PLASTIC (0054-4146-23)
0168- E. Fougera & Co. a division of Fougera Pharmaceuticals Inc.