Ciprofloxacin
- PO (Adults ): Most infections: 500–750 mg every 12 hr. Complicated UTIs: 500 mg every 12 hr for 7–14 days. Uncomplicated UTIs: 250 mg every 12 hr for 3 days. Gonorrhea: 250-mg single dose. Inhalational anthrax (postexposure) or cutaneous anthrax: 500 mg every 12 hr for 60 days; Plague: 500–750 mg every 12 hr for 14 days.
- PO (Children 1–17 yr): Complicated UTIs: 10–15 mg/kg every 12 hr (max = 750 mg/dose) for 10–21 days. Inhalational anthrax (postexposure) or cutaneous anthrax: 10–15 mg/kg every 12 hr (max = 500 mg/dose) for 60 days; Plague: 15 mg/kg every 8–12 hr (max = 500 mg/dose) for 14 days.
- IV (Adults ): Most infections: 400 mg every 12 hr. Complicated UTIs: 400 mg every 12 hr for 7–14 days. Uncomplicated UTIs: 200 mg every 12 hr for 7–14 days. Inhalational anthrax (postexposure): 400 mg every 12 hr for 60 days; Plague: 400 mg every 8–12 hr for 14 days.
- IV (Children 1–17 yr): Inhalational anthrax (postexposure): 10 mg/kg every 12 hr (not to exceed 400 mg/dose) for 60 days; Complicated UTIs: 6–10 mg/kg every 8 hr (max = 400 mg/dose) for 10–21 days; Plague: 10 mg/kg every 8–12 hr (max = 400 mg/dose) for 10–21 days.
Renal Impairment
- PO (Adults ): CCr 30–50 mL/min: 250–500 mg every 12 hr; CCr 5–29 mL/min: 250–500 mg every 18 hr.
- IV (Adults ): CCr 5–29 mL/min: 200–400 mg every 18–24 hr.
Delafloxacin
- IV (Adults ): 300 mg every 12 hr for 5–14 days (for acute bacterial skin and skin structure infections) or 5–10 days (for community-acquired pneumonia [CAP]) or 300 mg every 12 hr followed by switching to oral regimen (at dose stated below) for a total of 5–14 days (for acute bacterial skin and skin structure infections) or 5–10 days (for CAP).
- PO (Adults ): 450 mg every 12 hr for 5–14 days (for acute bacterial skin and skin structure infections) or 5–10 days (for CAP).
Renal Impairment
- IV (Adults ): eGFR 15–29 mL/min: 200 mg every 12 hr for 5–14 days (for acute bacterial skin and skin structure infections) or 5–10 days (for CAP) or 200 mg every 12 hr followed by switching to oral regimen (450 mg every 12 hr) for a total of 5–14 days (for acute bacterial skin and skin structure infections) or 5–10 days (for CAP); eGFR <15 mL/min: Not recommended.
Levofloxacin
- PO IV (Adults ): Most infections: 250–750 mg every 24 hr; Inhalational anthrax (postexposure): 500 mg once daily for 60 days.
- PO IV (Children >50 kg): Inhalational anthrax (postexposure): 500 mg once daily for 60 days; Plague: 500 mg once daily for 10–14 days.
- PO IV (Children <50 kg and ≥6 mo): Inhalational anthrax (postexposure): 8 mg/kg (max: 250 mg/dose) every 12 hr for 60 days. Plague: 8 mg/kg (max: 250 mg/dose) every 12 hr for 10–14 days; Other infections: 10 mg/kg/dose every 24 hr (max: 500 mg/dose).
Renal Impairment
- PO IV (Adults ): Normal renal function dosing of 750 mg/day: CCr 20–49 mL/min: 750 mg every 48 hr; CCr 10–19 mL/min: 750 mg initially, then 500 mg every 48 hr; Normal renal function dosing of 500 mg/day: CCr 20–49 mL/min: 500 mg initially then 250 mg every 24 hr; CCr 10–19 mL/min: 500 mg initially then 250 mg every 48 hr. Normal renal function dosing of 250 mg/day: CCr 10–19 mL/min: 250 mg every 48 hr.
Moxifloxacin
- PO IV (Adults ): Bacterial sinusitis: 400 mg once daily for 10 days; CAP: 400 mg once daily for 7–14 days. Acute bacterial exacerbation of chronic bronchitis: 400 mg once daily for 5 days. Complicated intra-abdominal infection: 400 mg once daily for 5–14 days. Skin/skin structure infections: 400 mg/day for 7–21 days. Treatment/prevention of plague: 400 mg once daily for 10–14 days.
Ofloxacin
- PO (Adults ): Most infections: 400 mg every 12 hr. Prostatitis: 300 mg every 12 hr for 6 wk. Uncomplicated UTIs: 200 mg every 12 hr for 3–7 days. Complicated UTIs: 200 mg every 12 hr for 10 days. Gonorrhea: 400-mg single dose.
Renal Impairment
- PO IV (Adults ): CCr 20–50 mL/min: 100% of the usual dose every 24 hr; CCr <20 mL/min: 50% of the usual dose every 24 hr.