Prevention of Deficiency (Recommended Daily Allowance)
- PO (Adults and Children >14 yr): 1.2–1.7 mg/day (larger doses required with cycloserine, ethionamide, hydralazine, immunosuppressants, isoniazid, penicillamine, and estrogen-containing oral contraceptives).
- PO (Children 9–13 yr): 1 mg/day (larger doses required with cycloserine, ethionamide, hydralazine, immunosuppressants, isoniazid, and penicillamine).
- PO (Children 1–8 yr): 0.5–0.6 mg/day (larger doses required with cycloserine, ethionamide, hydralazine, immunosuppressants, isoniazid, and penicillamine).
- PO (Infants 6–12 mo): 0.3 mg/day.
- PO (Infants <6 mo): 0.1 mg/day.
Treatment of Deficiency
- PO (Adults ): 2.5–10 mg/day until clinical signs are corrected, then 2–5 mg/day.
- PO (Children ): 5–25 mg/day for 3 wk, then 1.5–2.5 mg/day.
Pyridoxine-Dependent Seizures
- PO IM IV (Neonates and Infants): 10–100 mg initially, then 50–100 mg/day orally.
Drug-Induced Neuritis
- PO (Adults ): Treatment: 100–300 mg/day; Prophylaxis: 25–100 mg/day.
- PO (Children ): Treatment: 10–50 mg/day; Prophylaxis: 1–2 mg/kg/day.
Isoniazid Overdose (>10 g)
- IM IV (Adults and Children ): Amount in mg equal to amount of isoniazid ingested given as 1–4 g IV, then 1 g IM every 30 min.