section name header

Pronunciation ⬇

o-sel-TAM-i-vir

Classifications ⬆ ⬇

Therapeutic Classification: antivirals

Pharmacologic Classification: neuraminidase inhibitors

Indications ⬆ ⬇

REMS


Action ⬆ ⬇

  • Inhibits the enzyme neuraminidase, which may alter virus particle aggregation and release.
Therapeutic effects:
  • Reduced duration or prevention of flu-related symptoms.

Pharmacokinetics ⬆ ⬇

Absorption: Rapidly absorbed from the GI tract; 75% reaches systemic circulation as the active drug.

Distribution: Well distributed to tissues.

Metabolism/Excretion: Rapidly metabolized by the liver to oseltamivir carboxylate, the active drug. >99% excreted unchanged in urine.

Half-Life: Oseltamivir carboxylate: 6–10 hr.

Time/Action Profile ⬆ ⬇

( plasma concentrations)

ROUTEONSETPEAKDURATION
POunknownunknown12 hr

Contraind./Precautions ⬆ ⬇

Contraindicated in:

Use Cautiously in:

Adv. Reactions/Side Effects ⬆ ⬇

Interactions ⬆ ⬇

Drug-drug:

Route/Dosage ⬆ ⬇

Treatment of Influenza

Renal Impairment

Influenza Prevention

Renal Impairment

Availability ⬆ ⬇

(Generic available)

Assessment ⬆ ⬇

Implementation ⬆ ⬇

Patient/Family Teaching ⬆ ⬇

Evaluation/Desired Outcomes ⬆ ⬇

US Brand Names ⬆ ⬇

Tamiflu

Code ⬆

NDC Code