dipyridamole

dye-peer-ID-a-mole

Therapeutic Classification: antiplatelet agents, diagnostic agents (coronary vasodilators)

Pharmacologic Classification: platelet adhesion inhibitors

REMS

As an alternative to exercise in myocardial perfusion scintigraphy (cardiac stress testing with radiotracer imaging).

Produces coronary vasodilation by inhibiting adenosine uptake.

Therapeutic effects:

In diagnostic thallium imaging, dipyridamole dilates normal coronary arteries, reducing flow to vessels that are narrowed and causing abnormal thallium distribution.

Absorption: IV administration results in complete bioavailability.

Distribution: Widely distributed to tissues.

Metabolism/Excretion: Metabolized by the liver; excreted in the bile.

Half-Life: 10 hr.

(coronary vasodilation)

ROUTE	ONSET	PEAK	DURATION
IV	unknown	6.5 min	30 min

Contraindicated in:

Hypersensitivity.

Use Cautiously in:

Hypotension;
Patients with platelet defects;
OB: Use during pregnancy only if potential maternal benefit justifies potential fetal risk;
Lactation: Use while breastfeeding only if potential maternal benefit justifies potential risk to infant;
Pedi: Children <6 yr (safety and effectiveness not established);

CV: hypotension, arrhythmias, flushing, MI

GI: nausea, diarrhea, GI upset, vomiting

Derm: rash

Neuro: dizziness, headache, syncope, transient cerebral ischemia, weakness

Resp: bronchospasm

Drug-drug:

Anticoagulants, thrombolytic agents, NSAIDs, cefotetan, or valproic acid may ↑ risk of bleeding.
↑risk of hypotension with alcohol.
Theophylline may ↓ effectiveness.

IV (Adults ): 570 mcg/kg (max dose = 60 mg).

(Generic available)

Solution for injection: 5 mg/mL
In combination with:
aspirin.

Monitor vital signs during and for 10–15 min after infusion. Obtain ECG in at least 1 lead. If severe hypotension occurs, place patient in a supine position with head tilting down. If severe chest pain or bronchospasm occurs, administer IV aminophylline 50–250 mg at a rate of 50–100 mg over 30–60 sec. If chest pain is unrelieved with aminophylline 250 mg, administer nitroglycerin SL. Treat as myocardial infarction if chest pain persists after nitroglycerin.

Lab Test Considerations:

Monitor bleeding time periodically during therapy.

IV Administration:

Intermittent Infusion: Diluent: Dilute in at least a 1:2 ratio of 0.45% NaCl, 0.9% NaCl, or D5W for a total volume of 20–50 mL. Undiluted dipyridamole may cause venous irritation.
Rate: Infuse over 4 min.

Explain purpose and side effects of medication. Advise patient to read Patient Information before starting therapy.
- Advise patient to consult health care professional before taking OTC medications concurrently with this medication.
- Advise patient to avoid the use of alcohol, as it may potentiate hypotensive effects. Tobacco products should also be avoided because nicotine causes vasoconstriction.
- Caution patient to change positions slowly to minimize orthostatic hypotension.
- Instruct patient to notify health care professional if unusual bleeding or bruising occurs. .
Rep: Advise women of reproductive potential to notify health care professional if pregnancy is planned or suspected or if breastfeeding.

Coronary vasodilation in thallium myocardial perfusion imaging.

~~Persantine~~

Persantine

NDC Code

0115- Amneal Pharmaceuticals of New York LLC
- 0115-1070- Dipyridamole
  - 0115-1070-01- 100 TABLET in 1 BOTTLE (0115-1070-01)

0115- Amneal Pharmaceuticals of New York LLC
- 0115-1071- Dipyridamole
  - 0115-1071-01- 100 TABLET in 1 BOTTLE (0115-1071-01)

0115- Amneal Pharmaceuticals of New York LLC
- 0115-1072- Dipyridamole
  - 0115-1072-01- 100 TABLET in 1 BOTTLE (0115-1072-01)

0404- Henry Schein, Inc.
- 0404-9852- Dipyridamole
  - 0404-9852-10- 1 VIAL, SINGLE-DOSE in 1 BAG (0404-9852-10) / 10 mL in 1 VIAL, SINGLE-DOSE

0641- Hikma Pharmaceuticals USA Inc.
- 0641-2569- Dipyridamole
  - 0641-2569-44- 5 VIAL in 1 CARTON (0641-2569-44) / 10 mL in 1 VIAL (0641-2569-41)

12660- Societa Italiana Medicinali Scandicci S.I.M.S., SrL
- 12660-0084-
  - 12660-0084-1- 25 kg in 1 DRUM (12660-0084-1)

17511- COHANCE LIFESCIENCES LIMITED
- 17511-122-
  - 17511-122-06- 1 kg in 1 DRUM (17511-122-06)

51662- HF Acquisition Co LLC, DBA HealthFirst
- 51662-1447- DIPYRIDAMOLE
  - 51662-1447-1- 10 mL in 1 VIAL (51662-1447-1)

51927- Professional Compounding Centers of America dba PCCA
- 51927-1571-
  - 51927-1571-0- 1 kg in 1 CONTAINER (51927-1571-0)

65015- Mylan Laboratories Limited
- 65015-782-
  65015-782-61- 100 kg in 1 DRUM (65015-782-61)

65404- AGC Pharma Chemicals Europe, S.L.U.
- 65404-005-
  65404-005-01- 35000000 mg in 1 DRUM (65404-005-01)

65841- Zydus Lifesciences Limited
- 65841-662- Dipyridamole
  65841-662-01- 100 TABLET, FILM COATED in 1 BOTTLE (65841-662-01)

65841- Zydus Lifesciences Limited
- 65841-662- Dipyridamole
  - 65841-662-05- 500 TABLET, FILM COATED in 1 BOTTLE (65841-662-05)

65841- Zydus Lifesciences Limited
- 65841-662- Dipyridamole
  - 65841-662-10- 1000 TABLET, FILM COATED in 1 BOTTLE (65841-662-10)

65841- Zydus Lifesciences Limited
- 65841-662- Dipyridamole
  - 65841-662-77- 10 BLISTER PACK in 1 CARTON (65841-662-77) / 10 TABLET, FILM COATED in 1 BLISTER PACK

65841- Zydus Lifesciences Limited
- 65841-663- Dipyridamole
  - 65841-663-01- 100 TABLET, FILM COATED in 1 BOTTLE (65841-663-01)

65841- Zydus Lifesciences Limited
- 65841-663- Dipyridamole
  - 65841-663-05- 500 TABLET, FILM COATED in 1 BOTTLE (65841-663-05)

65841- Zydus Lifesciences Limited
- 65841-663- Dipyridamole
  - 65841-663-10- 1000 TABLET, FILM COATED in 1 BOTTLE (65841-663-10)

65841- Zydus Lifesciences Limited
- 65841-663- Dipyridamole
  - 65841-663-77- 10 BLISTER PACK in 1 CARTON (65841-663-77) / 10 TABLET, FILM COATED in 1 BLISTER PACK

65841- Zydus Lifesciences Limited
- 65841-664- Dipyridamole
  - 65841-664-01- 100 TABLET, FILM COATED in 1 BOTTLE (65841-664-01)

65841- Zydus Lifesciences Limited
- 65841-664- Dipyridamole
  - 65841-664-05- 500 TABLET, FILM COATED in 1 BOTTLE (65841-664-05)

65841- Zydus Lifesciences Limited
- 65841-664- Dipyridamole
  - 65841-664-10- 1000 TABLET, FILM COATED in 1 BOTTLE (65841-664-10)

65841- Zydus Lifesciences Limited
- 65841-664- Dipyridamole
  - 65841-664-77- 10 BLISTER PACK in 1 CARTON (65841-664-77) / 10 TABLET, FILM COATED in 1 BLISTER PACK

66039- Glenmark Life Sciences Limited
- 66039-917-
  - 66039-917-04- 50 kg in 1 DRUM (66039-917-04)

68382- Zydus Pharmaceuticals USA Inc.
- 68382-187- Dipyridamole
  68382-187-01- 100 TABLET, FILM COATED in 1 BOTTLE (68382-187-01)

68382- Zydus Pharmaceuticals USA Inc.
- 68382-187- Dipyridamole
  - 68382-187-05- 500 TABLET, FILM COATED in 1 BOTTLE (68382-187-05)

68382- Zydus Pharmaceuticals USA Inc.
- 68382-187- Dipyridamole
  - 68382-187-10- 1000 TABLET, FILM COATED in 1 BOTTLE (68382-187-10)

68382- Zydus Pharmaceuticals USA Inc.
- 68382-187- Dipyridamole
  - 68382-187-77- 10 BLISTER PACK in 1 CARTON (68382-187-77) / 10 TABLET, FILM COATED in 1 BLISTER PACK

68382- Zydus Pharmaceuticals USA Inc.
- 68382-188- Dipyridamole
  - 68382-188-01- 100 TABLET, FILM COATED in 1 BOTTLE (68382-188-01)

68382- Zydus Pharmaceuticals USA Inc.
- 68382-188- Dipyridamole
  - 68382-188-05- 500 TABLET, FILM COATED in 1 BOTTLE (68382-188-05)

68382- Zydus Pharmaceuticals USA Inc.
- 68382-188- Dipyridamole
  - 68382-188-10- 1000 TABLET, FILM COATED in 1 BOTTLE (68382-188-10)

68382- Zydus Pharmaceuticals USA Inc.
- 68382-188- Dipyridamole
  - 68382-188-77- 10 BLISTER PACK in 1 CARTON (68382-188-77) / 10 TABLET, FILM COATED in 1 BLISTER PACK

68382- Zydus Pharmaceuticals USA Inc.
- 68382-189- Dipyridamole
  - 68382-189-01- 100 TABLET, FILM COATED in 1 BOTTLE (68382-189-01)

68382- Zydus Pharmaceuticals USA Inc.
- 68382-189- Dipyridamole
  - 68382-189-05- 500 TABLET, FILM COATED in 1 BOTTLE (68382-189-05)

68382- Zydus Pharmaceuticals USA Inc.
- 68382-189- Dipyridamole
  - 68382-189-10- 1000 TABLET, FILM COATED in 1 BOTTLE (68382-189-10)

68382- Zydus Pharmaceuticals USA Inc.
- 68382-189- Dipyridamole
  - 68382-189-77- 10 BLISTER PACK in 1 CARTON (68382-189-77) / 10 TABLET, FILM COATED in 1 BLISTER PACK

69584- Oxford Pharmaceuticals, LLC
- 69584-181- Dipyridamole
  - 69584-181-10- 100 TABLET, FILM COATED in 1 BOTTLE (69584-181-10)

69584- Oxford Pharmaceuticals, LLC
- 69584-182- Dipyridamole
  - 69584-182-10- 100 TABLET, FILM COATED in 1 BOTTLE (69584-182-10)

69584- Oxford Pharmaceuticals, LLC
- 69584-183- Dipyridamole
  - 69584-183-10- 100 TABLET, FILM COATED in 1 BOTTLE (69584-183-10)

71205- Proficient Rx LP
- 71205-894- DIPYRIDAMOLE
  - 71205-894-00- 100 TABLET, FILM COATED in 1 BOTTLE (71205-894-00)

71205- Proficient Rx LP
- 71205-894- DIPYRIDAMOLE
  - 71205-894-11- 1000 TABLET, FILM COATED in 1 BOTTLE (71205-894-11)

71205- Proficient Rx LP
- 71205-894- DIPYRIDAMOLE
  - 71205-894-30- 30 TABLET, FILM COATED in 1 BOTTLE (71205-894-30)

71205- Proficient Rx LP
- 71205-894- DIPYRIDAMOLE
  - 71205-894-55- 500 TABLET, FILM COATED in 1 BOTTLE (71205-894-55)

71205- Proficient Rx LP
- 71205-894- DIPYRIDAMOLE
  - 71205-894-60- 60 TABLET, FILM COATED in 1 BOTTLE (71205-894-60)

71205- Proficient Rx LP
- 71205-894- DIPYRIDAMOLE
  - 71205-894-90- 90 TABLET, FILM COATED in 1 BOTTLE (71205-894-90)

71205- Proficient Rx LP
- 71205-895- DIPYRIDAMOLE
  - 71205-895-00- 100 TABLET, FILM COATED in 1 BOTTLE (71205-895-00)

71205- Proficient Rx LP
- 71205-895- DIPYRIDAMOLE
  - 71205-895-11- 1000 TABLET, FILM COATED in 1 BOTTLE (71205-895-11)

71205- Proficient Rx LP
- 71205-895- DIPYRIDAMOLE
  - 71205-895-30- 30 TABLET, FILM COATED in 1 BOTTLE (71205-895-30)

71205- Proficient Rx LP
- 71205-895- DIPYRIDAMOLE
  - 71205-895-55- 500 TABLET, FILM COATED in 1 BOTTLE (71205-895-55)

71205- Proficient Rx LP
- 71205-895- DIPYRIDAMOLE
  - 71205-895-60- 60 TABLET, FILM COATED in 1 BOTTLE (71205-895-60)

71205- Proficient Rx LP
- 71205-895- DIPYRIDAMOLE
  - 71205-895-90- 90 TABLET, FILM COATED in 1 BOTTLE (71205-895-90)

71205- Proficient Rx LP
- 71205-896- DIPYRIDAMOLE
  - 71205-896-00- 100 TABLET, FILM COATED in 1 BOTTLE (71205-896-00)

71205- Proficient Rx LP
- 71205-896- DIPYRIDAMOLE
  - 71205-896-11- 1000 TABLET, FILM COATED in 1 BOTTLE (71205-896-11)

71205- Proficient Rx LP
- 71205-896- DIPYRIDAMOLE
  - 71205-896-30- 30 TABLET, FILM COATED in 1 BOTTLE (71205-896-30)

71205- Proficient Rx LP
- 71205-896- DIPYRIDAMOLE
  - 71205-896-55- 500 TABLET, FILM COATED in 1 BOTTLE (71205-896-55)

71205- Proficient Rx LP
- 71205-896- DIPYRIDAMOLE
  - 71205-896-60- 60 TABLET, FILM COATED in 1 BOTTLE (71205-896-60)

71205- Proficient Rx LP
- 71205-896- DIPYRIDAMOLE
  - 71205-896-90- 90 TABLET, FILM COATED in 1 BOTTLE (71205-896-90)

84206- Tianish Laboratories Private Limited
- 84206-0029-
  - 84206-0029-1- 100 kg in 1 DRUM (84206-0029-1)

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Indications ⬆ ⬇

Action ⬆ ⬇

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