Information
Cyclophosphamide + Methotrexate + 5-Flourouracil (CMF-Bonadonna Regimen)1,45- Prechemo: CBC, Chem, LFTs, and CA 27–29. 5-HT3 and dexamethasone 20 mg in 100 cc of NS on days 1 and 8. Oral 5-HT3 or phenothiazine days 2–7 and 9–14. Moderately to highly emetogenic.
- Cyclophosphamide 100 mg/m2/day: PO on days 1–14. (25- and 50-mg tablets.) Take with meals in morning or early afternoon to allow adequate excretion time.
- Methotrexate 40 mg/m2: IV on days 1 and 8.
- 5-Flourouracil 600 mg/m2: IV on days 1 and 8.
- Side effects: Cyclophosphamide can cause rhinitis and irritation of nose and throat. Myelosuppression can be severe. Thrombocytopenia is less frequent, and anemia is mild. Nausea and vomiting. Mucositis and diarrhea can be severe, dose dependent. Acute renal failure, azotemia, urinary retention, and uric acid nephropathy have been observed with methotrexate. Hemorrhagic cystitis, dysuria, and urinary frequency with cyclophosphamide. SIADH. Photophobia, increased lacrimation, acute and chronic conjunctivitis, blepharitis, and blurred vision. Alopecia. Hyperpigmentation of nails and skin, banding of nails, and radiation recall may occur. Photosensitivity, sunburn-like rash. Hand-foot syndrome can be dose-limiting.
- Chair time: 1 hour on days 1 and 8. Repeat cycle every 28 days for six cycles.