Information
Cyclophosphamide + Methotrexate + 5-Flourouracil (CMF-Bonadonna Regimen)1,45- Prechemo: CBC, Chem, LFTs, and CA 27–29. 5-HT3 and dexamethasone 20 mg days 1 and 8. Oral 5-HT3 or phenothiazine days 2–7 and 9–14. Moderately to highly emetogenic.
- Cyclophosphamide 100 mg/m2/day: PO on days 1–14. (25- and 50-mg tablets.) Taken with meals in morning or early afternoon for adequate excretion time.
- Methotrexate 40 mg/m2: IV on days 1 and 8.
- 5-Flourouracil 500 mg/m2: IV on days 1 and 8.
- Side effects: Rhinitis and irritation of nose and throat. Myelosuppression. Nausea and vomiting. Mucositis and diarrhea severe, dose dependent. Acute renal failure, azotemia, urinary retention, and uric acid nephropathy with methotrexate. Hemorrhagic cystitis, dysuria, and urinary frequency with cyclophosphamide. SIADH. Photophobia, increased lacrimation, acute and chronic conjunctivitis, blepharitis, and blurred vision. Alopecia. Hyperpigmentation of nails and skin, banding of nails, and radiation recall. Photosensitivity, sunburn-like rash. Hand-foot syndrome can be dose-limiting.
- Chair time: 1 hour on days 1 and 8. Repeat every 28 days until disease progression.