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Table 20-5
Inherited Thrombophilias and Risk of Venous Thromboembolism (VTE) in Pregnancy
a
Thrombophilia
VTE Risk per Pregnancy (No History) (%)
VTE Risk per Pregnancy (Previous VTE) (%)
Percentage of All VTE
Factor V Leiden homozygosity
2-14
17
2
Prothrombin G20210A homozygosity
2-4
>
17
0.5
Factor V Leiden heterozygous
0.5-3
10
40
Prothrombin G20210A heterozygous
0.4-2.6
>
10
17
Protein C deficiency
0.1-1.7
4-17
14
Antithrombin deficiency
0.2-11.6
40
1
Protein S deficiency
0.3-6.6
0-22
3
Factor V Leiden + prothrombin G20210A (compound heterozygosity)
4-8
>
20
1-3
a
Adapted with permission from
American College of Obstetricians and Gynecologists Committee on Practice Bulletins
—
Obstetrics
.
ACOG Practice Bulletin No. 197: inherited thrombophilias in pregnancy
.
Obstet Gynecol
.
2018
;
132
(
1
):
e18
-
e34
.
Copyright © 2018 by The American College of Obstetricians and Gynecologists.