von Willebrand Disease Classification

von Willebrand Disease Classification^a

	Type 1	Type 2	Type 3
Mode of inheritance	AD	AD or AR	AR
Percentage of cases	75	Approximately 25	Rare
Pathophysiology	Partial deficiency of vWF	Qualitatively abnormal vWF	Markedly decreased or absent vWF
Clinical presentation	Asymptomatic to severe bleeding	Moderate to severe bleeding	Severe bleeding

Abbreviations: AD, autosomal dominant. AR, autosomal recessive; vWF, von Willebrand factor.