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Table 26.1

Commonly implicated drugs for different drug reactions

DRUG ERUPTION TYPECOMMONLY IMPLICATED DRUGS
Exanthems and urticarial reactionsSulfonamides, penicillins, hydantoins, allopurinol, quinidine, angiotensin-converting enzyme inhibitors, barbiturates, carbamazepine, isoniazid, NSAIDs, and phenothiazine, as well as thiazide diuretics, aspirin, blood products, cephalosporins, dextran, opiates, radiocontrast dye, ranitidine, and vaccines
Acneiform eruptionsSystemic steroids, topical steroids, lithium, oral contraceptives, and androgenic hormones
Photo-inducedTetracyclines, particularly demethylchlortetracycline and doxycycline; griseofulvin; certain diuretics such as HCTZ; sulfonylurea agents used to treat diabetes; NSAIDs; and phenothiazines
Bullous eruptionsPenicillin, sulfonamides, vancomycin, captopril, iodides, gold, and furosemide
PurpuraAnticoagulants and thiazides
Vasculitic eruptionsAllopurinol, aspirin or other NSAIDs, cimetidine, gold, hydralazine, penicillin, phenytoin, propylthiouracil, quinolones, sulfonamide, tetracycline, and thiazides
Erythema nodosumIodides, oral contraceptives, penicillin, gold, amiodarone, sulfonamides, and opiates
Erythema multiforme major (Stevens-Johnson syndrome) and erythema multiforme minorSulfonamides, penicillins, tetracyclines, hydantoins, and barbiturates
Fixed drug eruptionsTetracyclines, sulfonamides, griseofulvin, barbiturates, phenolphthalein, and NSAIDs
Contact dermatitisNeomycin and preservatives in topical medications