A pyogenic granuloma (PG) is a common vascular hyperplasia that arises on the skin and mucous membranes. PGs are most often in children and young adults.

Lesions may also arise during pregnancy (such a lesion is known as a granuloma gravidarum). PGs are also associated with oral contraceptive use.

The cause of PGs is unknown, but minor trauma and hormonal factors appear to be factors in their development.

PG lesions are benign, rapidly developing, red, purple, or red-brown, dome-shaped papules or nodules. They resemble hemangiomas or granulation tissue (“proud flesh”).

Lesions are asymptomatic but tend to readily bleed after minor trauma.

PGs are generally solitary and range in size from a few millimeters to 3 to 4 cm in diameter (Fig. 30.47).

The bases of lesions are often surrounded by a collarette of skin.

PG papules or nodules may be crusted.

PGs most frequently occur at sites of minor trauma, such as the fingers (Fig. 30.48) and toes, but they also may be seen on the trunk.

During pregnancy, lesions tend to occur on the lips (Fig. 30.49), gums, and buccal mucosa. Spontaneous resolution often occurs after childbirth.

The diagnosis is usually based on the typical clinical appearance or a shave biopsy, if necessary.