| Anatomic Location/Morphology | Risk | Intervention |
| Perineal, axilla, neck, perioral | Ulceration, disfigurement, feeding difficulties (perioral) | Close monitoring, identify premonitory gray-white color, treat early (i.e., <8 weeks) |
| Nasal tip, ear, large facial (esp. deep component) | Permanent scarring, disfigurement | Identify risk and treat early (i.e., <8 wks) |
| Periorbital and retrobulbar | Ocular axis occlusion, astigmatism, amblyopia, tear duct occlusion | Identify risk and treat early (i.e., <8 wks), baseline ophtho evaluation |
| Facial, large (>5 cm), segmental | PHACES syndrome (posterior fossa malformations, hemangiomas, arterial anomalies, cardiac defects, eye abnormalities, sternal clefting) | MRI/MRA head and neck
Echocardiogram
Ophtho evaluation
Systemic treatment |
| Segmental overlying lumbosacral spine | LUMBAR syndrome (lower body hemangioma, urogenital abnormalities, myelopathy, bony, and anorectal deformities) | MRI with contrast of spine
<3 mo can use ultrasound as initial screen
+/-Systemic treatment |
| Segmental “beard area” central neck | Airway hemangioma | Imaging
Systemic treatment |
| Multiple hemangiomas (>5) | Visceral involvement (esp. liver and GI tract)
“Multiple cutaneous hemangiomas with or without systemic hemangiomas” | Liver ultrasound, systemic treatment if liver IH present |