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Basics

Clinical Manifestations

Diagnosis

Diagnosis-icon.jpg Differential Diagnosis

Bullous Impetigo
  • Superficial flaccid vesicles or bullae that rupture easily. Little to no surrounding redness.

  • Typically multiple lesions and located in intertriginous areas such as the diaper area and axillae.

  • Genetic skin condition that presents with variable amounts of skin blistering and erosions at birth.

  • New blisters will form easily at sites of trauma or friction.

Neonatal Herpes Infection
  • Grouped vesicles on an erythematous base may be on any cutaneous surface and involve the mucosa; when ruptured, lesions appear as punched out erosions.

  • Tzanck smear of vesicle base will show multinucleated giant cells. HSV culture or DFA will be positive for HSV1 or 2.

Management-icon.jpg Management

  • The most important first step in management is ruling out an infectious etiology or genetic skin condition.

  • Sucking blisters heal completely without scarring within 2 weeks.

  • Petrolatum ointment can be applied to lesion twice daily to hasten resolution.