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Indications

REMS

Contraind./Precautions

Contraindicated in:

Use Cautiously in:

Adv. Reactions/Side Effects

Related to hyperphosphatemia, unless otherwise indicated

CNS: confusion, listlessness, weakness.

Resp: hypernatremia — shortness of breath.

CV: ARRHYTHMIAS, CARDIAC ARREST, ECG changes (absent P waves, widening of the QRS complex with biphasic curve), hypotension; hypernatremia — edema.

GI: diarrhea, abdominal pain, nausea, vomiting.

F and E: hyperkalemia, hypernatremia, hyperphosphatemia, hypocalcemia, hypomagnesemia.

Local: irritation at IV site, phlebitis.

MS: hypocalcemia — tremors.

Neuro: flaccid paralysis, heaviness of legs, paresthesias of extremities.

Interactions

Drug-Drug:

Availability

(Generic available)

Route/Dosage

Action

Therapeutic Effects:

Classifications

Therapeutic Classification: mineral and electrolyte replacements/supplements

Pharmacologic Classification: phosphate supplements

Pharmacokinetics

Absorption: Administered IV only, resulting in complete bioavailability.

Distribution: Phosphates enter extracellular fluids and are then actively transported to sites of action.

Metabolism/Excretion: Excreted mainly (>90%) by the kidneys.

Half-life: Unknown.

Time/Action Profile

(effects on serum phosphate levels)

ROUTEONSETPEAKDURATION
IVrapid (min–hr)end of infusionunknown

Patient/Family Teaching

Pronunciation

SOE-dee-umFOSS -fate audio

Code

NDC Code*