• Induces ovulation in anovulatory women who desire pregnancy. Requires intact anterior pituitary, thyroid, and adrenal function.

Unlabeled Use:

• Male infertility due to oligospermia.

Contraindicated in:

• Liver disease or history of liver dysfunction
• Enlargement or development of ovarian cysts (not due to polycystic ovarian syndrome)
• Pregnancy
• Uncontrolled thyroid or adrenal dysfunction
• Pituitary tumor
• Abnormal uterine bleeding of unknown origin.

Use Cautiously in:

• Endometriosis
• Fibroids
• Known sensitivity to pituitary gonadotropins (e.g. polycystic ovary syndrome).

CNS: headache.

EENT: blurred vision, floaters, photophobia, scotomata, phosphenes.

CV: hot flashes.

GI: abdominal pain, bloating, distention, nausea, vomiting, ↑ liver enzymes.

Endo: ovarian cyst formation, ovarian enlargement, breast discomfort, multiple births, intermenstrual spotting, ovarian hyperstimulation syndrome, abnormal menstrual flow.

Metab: weight gain.

Drug-Drug:

• None significant.

• Tablets: 50 mg;

Ovulatory Failure (Females)

• PO (Adults): 50 mg/day for 5 days (begin on or about 5th day of cycle); if ovulation does not occur, a second course of 100 mg/day for 5 days may be given 30 days after the initial course. A maximum of 3 courses may be administered. ↑ dose above 100 mg/day for 5 days is not recommended.

Male Infertility

• PO (Adults): 25 mg/day for 25 days with 5 days rest or 100 mg every Monday, Wednesday, and Friday.

Clomid, Serophene

• Stimulates release of pituitary gonadotropins, follicle-stimulating hormone, and luteinizing hormone, resulting in ovulation and the development of the corpus luteum.

• Induction of ovulation.

Therapeutic Classification: ovulation inducer

Absorption: Well absorbed following oral administration.

Distribution: Unknown.

Metabolism/Excretion: Metabolized by the liver, with enterohepatic recirculation. Excreted in feces.

Half-life: 5–7 days.

(ovulation)

• Instruct patient to take clomiphene exactly as directed at the same time each day. Missed doses should be taken as soon as remembered and the dose doubled if not remembered until the time of the next dose. Notify health care professional if more than one dose is missed.
• Advise patient that conception should be attempted with intercourse every other day starting 48 hr prior to ovulation. Ovulation usually occurs 7 days (range 5–10) after last dose of clomiphene.
• Instruct patient in the correct method for measuring basal body temperature. A record of the daily basal body temperature should be maintained prior to and throughout course of therapy. Emphasize the importance of compliance with all aspects of therapy.
• Prior to therapy, patient should be informed of the potential for multiple births.
• Medication may cause visual disturbances or dizziness. Caution patient to avoid driving until the response to the medication is known.
• Instruct patient to notify health care professional immediately if pregnancy is suspected; clomiphene should not be taken during pregnancy.
• Advise patient to notify health care professional if visual changes occur; therapy should be discontinued and an ophthalmologic exam performed. Blurring and potentially irreversible changes may occur.
• Advise patient to notify health care professional promptly if bloating, stomach or pelvic pain, blurred vision, jaundice, persistent hot flashes, breast discomfort, headache, diarrhea, weight gain, or nausea and vomiting occur.
• Emphasize the importance of close monitoring by health care professional throughout therapy.

KLOE-mi-feen

NDC Code^*

• 49884- Par Pharmaceutical, Inc.
  • 49884-701- Clomiphene Citrate
    • 49884-701-54- 1 BLISTER PACK in 1 CARTON (49884-701-54) > 10 TABLET in 1 BLISTER PACK

• 49884- Par Pharmaceutical, Inc.
  • 49884-701- Clomiphene Citrate
    • 49884-701-55- 3 BLISTER PACK in 1 CARTON (49884-701-55) > 10 TABLET in 1 BLISTER PACK

• 50090- A-S Medication Solutions
  • 50090-0677- Clomiphene Citrate
    • 50090-0677-1- 30 TABLET in 1 CARTON (50090-0677-1)

• 50090- A-S Medication Solutions
  • 50090-0678- Clomiphene Citrate
    • 50090-0678-1- 3 BLISTER PACK in 1 CARTON (50090-0678-1) > 10 TABLET in 1 BLISTER PACK

• 61919- DIRECTRX
  • 61919-375- CLOMIPHENE CITRATE
    • 61919-375-30- 30 TABLET in 1 CARTON (61919-375-30)

• 63629- Bryant Ranch Prepack
  • 63629-5302- Clomiphene Citrate
    • 63629-5302-1- 30 TABLET in 1 BOTTLE (63629-5302-1)

• 63629- Bryant Ranch Prepack
  • 63629-5302- Clomiphene Citrate
    • 63629-5302-2- 10 TABLET in 1 BOTTLE (63629-5302-2)

• 63629- Bryant Ranch Prepack
  • 63629-5302- Clomiphene Citrate
    • 63629-5302-3- 8 TABLET in 1 BOTTLE (63629-5302-3)

• 63629- Bryant Ranch Prepack
  • 63629-5302- Clomiphene Citrate
    • 63629-5302-4- 5 TABLET in 1 BOTTLE (63629-5302-4)

• 63629- Bryant Ranch Prepack
  • 63629-5302- Clomiphene Citrate
    • 63629-5302-5- 15 TABLET in 1 BOTTLE (63629-5302-5)

• 63629- Bryant Ranch Prepack
  • 63629-5302- Clomiphene Citrate
    • 63629-5302-6- 40 TABLET in 1 BOTTLE (63629-5302-6)

• 68071- NuCare Pharmaceuticals, Inc.
  • 68071-2166- Clomiphene Citrate
    • 68071-2166-1- 10 TABLET in 1 BOTTLE (68071-2166-1)

• 68071- NuCare Pharmaceuticals, Inc.
  • 68071-2166- Clomiphene Citrate
    • 68071-2166-2- 20 TABLET in 1 BOTTLE (68071-2166-2)

• 68071- NuCare Pharmaceuticals, Inc.
  • 68071-2166- Clomiphene Citrate
    • 68071-2166-4- 40 TABLET in 1 BOTTLE (68071-2166-4)

• 68071- NuCare Pharmaceuticals,Inc.
  • 68071-4676- Clomiphene Citrate
    • 68071-4676-3- 30 TABLET in 1 BOX (68071-4676-3)