Contraindicated in:
Use Cautiously in:
CV: edema, tachycardia.
Derm: exfoliation, pruritus, rash, TOXIC EPIDERMAL NECROLYSIS, ulceration.
EENT: epistaxis, pharyngolaryngeal pain.
F and E: dehydration, hypokalemia.
GI: mucositis, nausea, ↑ liver enzymes, abdominal pain, anorexia, constipation, diarrhea, vomiting.
Hemat: neutropenia, thrombocytopenia, anemia.
MS: back pain, extremity pain.
Neuro: fatigue.
Resp: dyspnea, cough.
Misc: fever, sepsis, night sweats, tumor lysis syndrome.
Drug-Drug:
Renal Impairment
Absorption: IV administration results in complete bioavailability.
Distribution: .
Metabolism/Excretion: Some metabolism by the liver; 34% excreted unchanged in urine.
Half-life: 1218 hr.
(effects on blood counts)
ROUTE | ONSET | PEAK | DURATION |
---|---|---|---|
IV | 45 days | unknown | unknown |
median time to first response.
NDC Code*