Contraindicated in:
Use Cautiously in:
CV: MI.
F and E: hypokalemia.
GI: constipation, dyspepsia, flatulence.
GU: urinary retention.
Hemat: anemia.
MS: back pain.
Drug-Drug:
Absorption: 6% absorbed following oral administration.
Distribution: Does not cross the blood-brain barrier.
Protein Binding: alvimopan: 80% bound to albumin; metabolite: 94% bound to albumin.
Metabolism/Excretion: Converted by bacterial flora in the GI tract to an active metabolite; elimination is mostly via biliary secretion, followed by conversion by bacterial flora. Elimination of unabsorbed drug and metabolites is via feces and urine.
Half-life: alvimopan: 1017 hr; metabolite: 1018 hr.
NDC Code*