- IV (Adults): 15 mg/m2 every 8 hr for 3 days; cycle should be repeated every 6 wk for a minimum of 4 cycles or 20 mg/m2 once daily for 5 days; cycle should be repeated every 4 wk for a minimum of 4 cycles.
Contraindicated in:
Use Cautiously in:
CV: atrial fibrillation, pulmonary edema, tachycardia.
Derm: petechiae, rash.
EENT: blurred vision.
F and E: edema, hypokalemia, hypomagnesemia, ascites.
GI: abdominal pain, constipation, diarrhea, stomatitis, vomiting, ↑ liver enzymes.
GU: ↓ fertility (males).
Hemat: anemia, neutropenia, thrombocytopenia, BLEEDING.
Local: injection site irritation.
Metab: hyperglycemia.
MS: arthralgia, myalgia.
Neuro: confusion, fatigue, insomnia, depression, lethargy.
Resp: cough.
Drug-Drug:
(Generic available)
Absorption: IV administration results in complete bioavailability.
Distribution: Unknown.
Metabolism/Excretion: Mostly metabolized by the liver.
Half-life: 0.5 hr.
NDC Code*
