LET-roe-zole 
Contraindicated in:
Use Cautiously in:
CV: chest pain, DEEP VEIN THROMBOSIS, edema, hypertension.
Derm: ↑ sweating, alopecia, hot flush, pruritus, rash.
F and E: hypercalcemia.
GI: nausea, abdominal pain, anorexia, constipation, diarrhea, dyspepsia, vomiting.
GU: ↓ fertility.
Metab: hypercholesterolemia, weight gain.
MS: musculoskeletal pain, ↓ bone density, arthralgia, fracture.
Neuro: anxiety, depression, dizziness, drowsiness, fatigue, headache, STROKE/TIA, vertigo, weakness.
Resp: cough, dyspnea, pleural effusion, PULMONARY EMBOLISM.
Hepatic Impairment
Absorption: Rapidly and completely absorbed.
Distribution: Well distributed to tissues.
Metabolism/Excretion: Mostly metabolized by the liver. Primarily excreted in the urine (90%), with 6% being excreted as unchanged drug.
Half-life: 2 days.
(effect on lowering of serum estradiol concentrations)
| ROUTE | ONSET | PEAK | DURATION |
|---|---|---|---|
| PO | unknown | 2–3 days | unknown |
NDC Code*