• Short-term management of HF caused by depressed contractility from organic heart disease or surgical procedures.

Contraindicated in:

• Hypersensitivity to dobutamine or bisulfites
• Idiopathic hypertrophic subaortic stenosis.

Use Cautiously in:

• Hypertension (↑ risk of exaggerated pressor response)
• MI
• Atrial fibrillation
• History of ventricular atopic activity (may be exacerbated)
• Hypovolemia (correct before administration)
• OB: Safety not established in pregnancy
• Lactation: Safety not established in breastfeeding.

CV: hypertension, premature ventricular contractions, tachycardia, angina, arrhythmias, hypotension, palpitations.

GI: nausea, vomiting.

Local: phlebitis.

Neuro: headache.

Resp: shortness of breath.

Misc: hypersensitivity reactions, nonanginal chest pain.

Drug-Drug:

• Beta blockers may negate the effect of dobutamine.
• ↑ risk of arrhythmias or hypertension with some anesthetics (cyclopropane, halothane), MAO inhibitors, oxytocics, or tricyclic antidepressants.

(Generic available)

• Solution for injection (requires dilution): 12.5 mg/mL;
• Premixed infusion: 250 mg/250 mL; 500 mg/250 mL; 1000 mg/250 mL;

• IV (Adults and Children): 2.5–15 mcg/kg/min; titrate to response (max dose = 40 mcg/kg/min).
• IV (Neonates): 2–15 mcg/kg/min.

Dobutrex

• Stimulates beta₁(myocardial)-adrenergic receptors with relatively minor effect on heart rate or peripheral blood vessels.

• Increased cardiac output without significantly increased heart rate.

Therapeutic Classification: inotropics

Pharmacologic Classification: adrenergics

Absorption: IV administration results in complete bioavailability.

Distribution: Unknown.

Metabolism/Excretion: Metabolized by the liver and other tissues.

Half-life: 2 min.

(inotropic effects)

• Explain to patient the dobutamine and the need for frequent monitoring.
• Advise patient to inform nurse immediately if chest pain; dyspnea; or numbness, tingling, or burning of extremities occurs.
• Instruct patient to notify nurse immediately of pain or discomfort at the site of administration.
• Rep: Advise females of reproductive potential to notify health care professional if pregnancy is planned or suspected or if breastfeeding.
• Home Care Issues: Instruct caregiver on proper care of IV equipment.
  • Instruct caregiver to report signs of worsening HF (shortness of breath, orthopnea, decreased exercise tolerance), abdominal pain, and nausea or vomiting to health care professional promptly.

doe-BYOO-ta-meen

NDC Code^*

• 0338- Baxter Healthcare Corporation
  • 0338-1073- Dobutamine Hydrochloride in Dextrose
    • 0338-1073-02- 18 BAG in 1 CARTON (0338-1073-02) > 250 mL in 1 BAG

• 0338- Baxter Healthcare Corporation
  • 0338-1075- Dobutamine Hydrochloride in Dextrose
    • 0338-1075-02- 18 BAG in 1 CARTON (0338-1075-02) > 250 mL in 1 BAG

• 0338- Baxter Healthcare Corporation
  • 0338-1077- Dobutamine Hydrochloride in Dextrose
    • 0338-1077-02- 18 BAG in 1 CARTON (0338-1077-02) > 250 mL in 1 BAG

• 0409- Hospira, Inc.
  • 0409-2025- DOBUTAMINE
    • 0409-2025-20- 10 VIAL, SINGLE-DOSE in 1 CARTON (0409-2025-20) > 20 mL in 1 VIAL, SINGLE-DOSE (0409-2025-60)

• 0409- Hospira, Inc.
  • 0409-2025- DOBUTAMINE
    • 0409-2025-54- 10 CARTON in 1 PACKAGE (0409-2025-54) > 1 VIAL, SINGLE-DOSE in 1 CARTON (0409-2025-64) > 40 mL in 1 VIAL, SINGLE-DOSE

• 0409- Hospira, Inc.
  • 0409-2344- DOBUTAMINE
    • 0409-2344-88- 10 VIAL, SINGLE-DOSE in 1 TRAY (0409-2344-88) > 20 mL in 1 VIAL, SINGLE-DOSE (0409-2344-68)

• 0409- Hospira, Inc.
  • 0409-2344- DOBUTAMINE
    • 0409-2344-01- 1 VIAL, SINGLE-DOSE in 1 CARTON (0409-2344-01) > 20 mL in 1 VIAL, SINGLE-DOSE

• 0409- Hospira, Inc.
  • 0409-2344- DOBUTAMINE
    • 0409-2344-02- 10 VIAL, SINGLE-DOSE in 1 TRAY (0409-2344-02) > 20 mL in 1 VIAL, SINGLE-DOSE (0409-2344-62)

• 50090- A-S Medication Solutions
  • 50090-4562- Dobutamine Hydrochloride in Dextrose
    • 50090-4562-0- 250 mL in 1 BAG (50090-4562-0)

• 51662- HF Acquisition Co LLC, DBA HealthFirst
  • 51662-1330- DOBUTAMINE
    • 51662-1330-1- 250 mL in 1 BAG (51662-1330-1)

• 51662- HF Acquisition Co LLC, DBA HealthFirst
  • 51662-1337- DOBUTAMINE
    • 51662-1337-1- 20 mL in 1 VIAL, SINGLE-DOSE (51662-1337-1)