• Bacterial vaginosis.
• Trichomoniasis.

Contraindicated in:

• Hypersensitivity; cross-sensitivity with other imidazoles may occur
• Cockayne syndrome (↑ risk of hepatotoxicity and death)
• Lactation: Lactation.

Use Cautiously in:

• OB: Safety not established in pregnancy
• Pedi: Children <12 yr (safety and effectiveness not established).

GI: abdominal pain, diarrhea, metallic taste, nausea, vomiting.

GU: vulvovaginal candidiasis, vulvovaginal pruritus.

Neuro: headache.

Drug-Drug:

• Alcohol or preparations containing ethanol or propylene glycol may lead to nausea, vomiting, diarrhea, abdominal pain, dizziness, and headache. Avoid use during secnidazole therapy and for ≥2 days after completing therapy.

• Oral granules: 2 g/pkt;

Bacterial Vaginosis

• PO (Adults and Children ≥12 yr): 2-g single dose.

Trichomoniasis

• PO (Adults and Children ≥12 yr): 2-g single dose. Any sexual partners should also be treated with a 2-g single dose.

Solosec

• Disrupts DNA synthesis in susceptible organisms.

• Resolution of bacterial vaginosis.
• Resolution of trichomoniasis.

Spectrum:

• Active against Bacteroides spp., Gardnerella vaginalis, Prevotella spp., Mobiluncus spp., and Trichomonas vaginalis.

Therapeutic Classification: anti-infectives

Pharmacologic Classification: imidazoles

Absorption: Rapidly and completely absorbed following oral administration.

Distribution: Extensively distributed to tissues.

Metabolism/Excretion: Primarily metabolized by CYP450 system in liver; 15% excreted unchanged in urine.

Half-life: 17 hr.

(plasma concentrations)

• Instruct patient in correct technique for taking secnidazole. Advise patient to read Patient Information before taking secnidazole.
• Advise patient to notify health care professional if signs and symptoms of vulvovaginal candidiasis (vaginal itching, white or yellowish discharge [discharge may be lumpy or look like cottage cheese]) occur. May require treatment with antifungal agents.
• Advise patient to avoid alcohol during and for 2 days after last dose of secnidazole. May cause nausea, vomiting, diarrhea, abdominal pain, dizziness, and headache when taken with alcohol.
• Advise patient to notify health care professional of all Rx or OTC medications, vitamins, or herbal products being taken and to consult with health care professional before taking other medications during therapy.
• Rep: Advise females of reproductive potential to notify health care professional if pregnancy is planned or suspected. Advise female patient to avoid breastfeeding for at least 96 hr (4 days) following secnidazole dose.

sek-NID-a-zole

NDC Code^*

• 27437- Lupin Pharmaceuticals, Inc.
  • 27437-051- SOLOSEC
    • 27437-051-01- 1 PACKET in 1 BOX, UNIT-DOSE (27437-051-01) > 2 g in 1 PACKET

• 27437- Lupin Pharmaceuticals, Inc.
  • 27437-051- SOLOSEC
    • 27437-051-02- 1 PACKET in 1 BOX, UNIT-DOSE (27437-051-02) > 2 g in 1 PACKET