Contraindicated in:
Use Cautiously in:
CNS: SEIZURES (VERY HIGH DOSES), headache.
GI: CLOSTRIDIUM DIFFICILE-ASSOCIATED DIARRHEA (CDAD), diarrhea, abdominal pain, nausea, vomiting.
Derm: rash, urticaria.
GU: vaginal moniliasis.
Hemat: bleeding, blood dyscrasias, hemolytic anemia.
Misc: ALLERGIC REACTIONS INCLUDING ANAPHYLAXIS , superinfection.
Drug-Drug:
(Generic available)
12 yr): Most infections — 200 mg every 12 hr; Skin and skin structure infections — 400 mg every 12 hr; Urinary tract infections/pharyngitis — 100 mg every 12 hr; Gonorrhea — 200 mg single dose.Renal Impairment
Spectrum:
-lactamase-producing strains),Therapeutic Classification: anti-infectives
Pharmacologic Classification: third generation cephalosporins
Absorption: Cefpodoxime proxetil is a prodrug that is converted to cefpodoxim (the active component) in GI tract during absorption; 50% absorbed after oral administration; absorption of tablets ↑ with food.
Distribution: Widely distributed. Crosses the placenta; enters breast milk.
Metabolism/Excretion: 29–33% excreted unchanged in urine.
Half-life: 2–3 hr (↑ in renal impairment).
NDC Code*
