Contraindicated in:
Use Cautiously in:
Derm: alopecia.
Endo: infertility.
GI: nausea, vomiting, anorexia, hepatotoxicity, stomatitis.
GU: azotemia, renal failure.
Hemat: leukopenia, thrombocytopenia, anemia.
Metab: hyperuricemia.
Neuro: ataxia, disorientation, dysarthria, lethargy.
Resp: fibrosis, pulmonary infiltrates.
Misc: secondary malignancy (long-term use).
Drug-Drug:
Absorption: Rapidly absorbed following oral administration.
Distribution: Widely distributed. Active metabolites enter the CSF well. Enters breast milk.
Metabolism/Excretion: Mostly metabolized by the liver. Some metabolites are active antineoplastic agents. Metabolites are excreted by the kidneys.
Half-life: 12 days (active metabolites).
NDC Code*