• Moderate-to-severe plaque psoriasis in patients who are candidates for systemic therapy or phototherapy.
• Active psoriatic arthritis (as monotherapy or in combination with a nonbiologic DMARD).
• Active ankylosing spondylitis.
• Active nonradiographic axial spondyloarthritis in patients with objective signs of inflammation.

Contraindicated in:

• Hypersensitivity
• Active tuberculosis.

Use Cautiously in:

• Inflammatory bowel disease (may lead to exacerbations)
• OB: Safety not established in pregnancy
• Lactation: Use while breastfeeding only if potential maternal benefit justifies potential risk to infant
• Pedi: Children <6 yr (safety and effectiveness not established).

GI: inflammatory bowel disease, nausea.

Hemat: neutropenia, thrombocytopenia.

Local: injection site reactions.

Misc: infection (including reactivation tuberculosis), HYPERSENSITIVITY REACTIONS (INCLUDING ANAPHYLAXIS, ANGIOEDEMA, AND URTICARIA).

Drug-Drug:

• May ↓ antibody response to live-virus vaccine and ↑ risk of adverse reactions (do not administer concurrently).

• Solution for injection (prefilled autoinjectors and prefilled syringes): 80 mg/mL;

Plaque Psoriasis

• SC (Adults): 160 mg (as two 80-mg injections) at Wk 0, then 80 mg at Wk 2, 4, 6, 8, 10, and 12, then 80 mg every 4 wk.
• SC (Children ≥6 yr and >50 kg): 160 mg (as two 80-mg injections) at Wk 0, then 80 mg every 4 wk.
• SC (Children ≥6 yr and 25–50 kg): 80 mg at Wk 0, then 40 mg every 4 wk.
• SC (Children ≥6 yr and <25 kg): 40 mg at Wk 0, then 20 mg every 4 wk.

Psoriatic Arthritis and Ankylosing Spondylitis

• SC (Adults): 160 mg (as two 80-mg injections) initially, then 80 mg every 4 wk.

Nonradiographic Axial Spondyloarthritis

• SC (Adults): 80 mg every 4 wk.

Taltz

• A monoclonal antibody that acts as an antagonist of interleukin (IL)–17A by selectively binding to it and preventing its interaction with the IL–17 receptor. Antagonism prevents the production of inflammatory cytokines and chemokines.

• Decreased plaque formation and spread in plaque psoriasis.
• Decreased pain and swelling with decreased joint destruction in psoriatic arthritis.
• Decreased disease activity in ankylosing spondylitis and nonradiographic axial spondyloarthritis.

Therapeutic Classification: antipsoriatics

Pharmacologic Classification: interleukin antagonists

Absorption: Well absorbed (60–81%) following SUBQ administration.

Distribution: Minimally distributed to tissues.

Metabolism/Excretion: Catabolized into small peptides and amino acids.

Half-life: 13 days.

(plasma concentrations)

• Instruct patient and caregiver in proper technique for self-injection and care and disposal of equipment. Administer missed doses as soon as possible and resume regular dosing schedule. Advise patient to read Medication Guide and Instructions for Use prior to starting therapy and with each Rx refill in case of changes.
• Advise patient to notify health care professional if signs and symptoms of allergic reaction, infection, or inflammatory bowel disease occur.
• Advise patient to avoid use of live vaccines during therapy.
• Instruct patient to notify health care professional of all Rx or OTC medications, vitamins, or herbal products being taken and consult health care professional before taking any new medications.
• Rep: Advise female patients of reproductive potential to notify health care professional if pregnancy is planned or suspected, or if breastfeeding. There is a pregnancy exposure registry that monitors pregnancy outcomes in women exposed to Taltzduring pregnancy. Pregnant women exposed to ixekizumab are encouraged to enroll in the pregnancy exposure registry that monitors pregnancy outcomes in women exposed to ixekizumab during pregnancy, by calling the Taltz Pregnancy Registry at 1-800-284-1695 or contacting the registry at www.taltz.com.

ix-ee-KIZ-ue-mab

NDC Code^*

• 0002- Eli Lilly and Company
  • 0002-1445- TALTZ
    • 0002-1445-09- 3 SYRINGE in 1 CARTON (0002-1445-09) > 1 mL in 1 SYRINGE (0002-1445-01)

• 0002- Eli Lilly and Company
  • 0002-1445- TALTZ
    • 0002-1445-11- 1 SYRINGE in 1 CARTON (0002-1445-11) > 1 mL in 1 SYRINGE (0002-1445-01)

• 0002- Eli Lilly and Company
  • 0002-1445- TALTZ
    • 0002-1445-27- 2 SYRINGE in 1 CARTON (0002-1445-27) > 1 mL in 1 SYRINGE (0002-1445-01)

• 0002- Eli Lilly and Company
  • 0002-1445- TALTZ
    • 0002-1445-61- 1 SYRINGE in 1 CARTON (0002-1445-61) > 1 mL in 1 SYRINGE

• 0002- Eli Lilly and Company
  • 0002-7724- TALTZ
    • 0002-7724-11- 1 SYRINGE in 1 CARTON (0002-7724-11) > 1 mL in 1 SYRINGE (0002-7724-01)

• 0002- Eli Lilly and Company
  • 0002-7724- TALTZ
    • 0002-7724-99- 1 SYRINGE in 1 CARTON (0002-7724-99) > 1 mL in 1 SYRINGE