- PO (Adults): Short-term treatment of active ulcers — 40 mg/day at bedtime or 20 mg twice daily for up to 8 wk.Duodenal ulcer prophylaxis — 20 mg once daily at bedtime. GERD — 20 mg twice daily for up to 6 wk; up to 40 mg twice daily for up to 12 wk for esophagitis with erosions, ulcerations, and continuing symptoms. Gastric hypersecretory conditions — 20 mg every 6 hr initially, up to 160 mg every 6 hr. OTC use — 10 mg for relief of symptoms; for prevention — 10 mg 60 min before eating or take 10 mg as chewable tablet 15 minutes before heartburn-inducing foods or beverages (not to exceed 20 mg/24 hr for up to 2 wk).
- PO, IV (Children 1–12 yr): Peptic ulcer — 0.5 mg/kg/day as a single bedtime dose or in divided doses twice daily (maximum: 40 mg daily); GERD — 1 mg/kg/day in divided doses twice daily (maximum: 80 mg daily).
- PO (Infants > 3 mo — 1 yr): GERD — 0.5 mg/kg/dose twice daily.
- PO (Infants and neonates <3 mo): GERD — 0.5 mg/kg/dose once daily.
- IV (Adults): 20 mg every 12 hr.
Renal Impairment
- PO (Adults): CCr 10–50 mL/min-administer normal dose every 24 hr or 50% dose at normal dosing intervalCCr <10 mL/min — 20 mg at bedtime; interval may need to be ↑ to every 36–48 hr.
