Contraindicated in:
Use Cautiously in:
CNS: headache, depression.
CV: peripheral edema.
GI: nausea, abdominal pain, constipation, ↓ appetite, flatulence, ↑ liver enzymes.
Misc: fever.
Drug-Drug:
Therapeutic Classification: antidiarrheals
Pharmacologic Classification: tryptophan hydroxylase inhibitors
Absorption: Absorption increased with food (especially high-fat meal).
Distribution: Unknown.
Protein Binding: >99%.
Metabolism/Excretion: Telotristat ethyl is metabolized via hydrolysis to active metabolite (telostriat); telotristat is further metabolized in the liver; primarily excreted in feces.
Half-life: Telotristat ethyl 0.6 hr; telotristat 5 hr.
(plasma levels)
ROUTE | ONSET | PEAK | DURATION |
---|---|---|---|
PO | unknown | 0.52 hr (telotstriat ethyl); 13 hr (telotstriat) | 8 hr |
NDC Code*