Contraindicated in:
Use Cautiously in:
CV: ↑ heart rate.
EENT: retinopathy complications.
Endo: hypoglycemia, MEDULLARY THYROID CARCINOMA.
GI: diarrhea, nausea, ↑ amylase, ↑ lipase, abdominal distension, abdominal pain, cholecystitis, cholelithiasis, constipation, dyspepsia, flatulence, gastroesophageal reflux disease, PANCREATITIS, vomiting.
GU: acute kidney injury.
Local: injection site reactions.
Metab: ↓ appetite.
Misc: HYPERSENSITIVITY REACTIONS (INCLUDING ANAPHYLAXIS AND ANGIOEDEMA).
Drug-Drug:
Therapeutic Classification: antidiabetics
Pharmacologic Classification: glucose-dependent insulinotropic polypeptide (GIP) receptor agonists
Absorption: 80% absorbed following subcutaneous administration.
Distribution: Minimally distributed to tissues.
Protein Binding: 99%.
Metabolism/Excretion: Metabolized by proteolytic cleavage, beta-oxidation, and amide hydrolysis. Excreted in the urine and feces, with very little being eliminated as unchanged drug.
Half-life: 5 days.